Results 11 to 20 of about 5,775 (200)
Transcriptional profiles in zebrafish atp7a mutants and responses of atp7a mutants to Cu stress
Water Biology and Security, 2023 As a copper (Cu) transport ATPase, ATP7A plays an important role in maintaining Cu homeostasis in the body, but the developmental and physiological roles of atp7a in zebrafish embryogenesis are rarely studied.
You Wu +4 more
doaj +3 more sources
Metal-dependent regulation of ATP7A and ATP7B in fibroblast cultures [PDF]
Frontiers in Molecular Neuroscience, 2016 Deficiency of one of the copper transporters ATP7A and ATP7B leads to the rare X-linked disorder Menkes Disease (MD) or the rare autosomal disorder Wilson disease (WD), respectively.
Lenartowicz Malgorzata +5 more
doaj +8 more sources
Genetic Diversity, Tissue-Specific Expression, and Functional Analysis of the ATP7A Gene in Sheep
Frontiers in Genetics, 2023 In humans, variation of the ATP7A gene may cause cranial exostosis, which is similar to “human horn,” but the function of the ATP7A gene in sheep is still unknown.
Zhangyuan Pan, Mingxing Chu, Xiaolong Du
exaly +3 more sources
Participation of ATP7A in macrophage mediated oxidation of LDL [PDF]
Journal of Lipid Research, 2010 ATP7A primarily functions to egress copper from cells, thereby supplying this cofactor to secreted copper-accepting enzymes. This ATPase has attracted significant attention since the discovery of its mutation leading to human Menkes disease and the ...
Zhenyu Qin +5 more
doaj +3 more sources
Frontiers in Molecular Biosciences, 2022 Copper (Cu) is an essential micronutrient with a critical role in mammalian growth and development. Imbalance of Cu causes severe diseases in humans; therefore, cellular Cu levels are tightly regulated.
Svetlana Lutsenko +2 more
exaly +3 more sources
TAp73 regulates ATP7A: possible implications for ageing-related diseases [PDF]
Aging, 2018 The p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice results in increased tumorigenesis, infertility, neurological defects and altered immune system. Despite the extensive effort directed to define the molecular underlying mechanism of p73 function a clear definition of its transcriptional signature and the ...
Lopriore, Piervito +6 more
core +10 more sources
Molecular Structure of the Menkes Disease Gene (ATP7A)
Genomics, 1995 We report a detailed molecular analysis of the genomic structure of the Menkes disease gene (MNK; ATP7A). There are 23 exons in ATP7A covering a genomic region of approximately 140 kb. The size of the individual coding exons varies between 77 and 726 bp, and introns vary in size between 196 bp and approximately 60 kb.
H A, Dierick +4 more
openaire +3 more sources
MiR-495 Inhibits Cisplatin Resistance and Angiogenesis in Esophageal Cancer by Targeting ATP7A
Technology in Cancer Research and Treatment, 2021 Background: Cancer resistance to chemotherapy is closely associated with changes in transporter systems. In this study, we investigated the possible regulation of 1 copper ion transporter (ATP7A; ATPase copper transporting alpha) by microRNA miR-495 and ...
Kejun Liu, Kejun Liu
exaly +2 more sources
Differential expression of ATP7A, ATP7B and CTR1 in adult rat dorsal root ganglion tissue [PDF]
Molecular Pain, 2010 Background ATP7A, ATP7B and CTR1 are metal transporting proteins that control the cellular disposition of copper and platinum drugs, but their expression in dorsal root ganglion (DRG) tissue and their role in platinum-induced neurotoxicity are unknown ...
Ip Virginia +3 more
doaj +4 more sources
ATP7A and LIAS promote lung adenocarcinoma progression through regulation of cuproptosis [PDF]
Cancer Cell InternationalBackground Cuproptosis has been implicated in lung adenocarcinoma (LUAD), but whether it contributes to the biological functions of ATPase copper transporting alpha (ATP7A) and lipoic acid synthetase (LIAS) remains unclear.
Wen-Zhou Liu +6 more
doaj +2 more sources