Results 71 to 80 of about 9,465 (268)
Cancer Reports, 2023 Cuproptosis has been studied in various aspects as a new form of cell death.
Shanbao Li +9 more
semanticscholar +1 more source
Cells, 2019 Membrane trafficking pathways emanating from the Golgi regulate a wide range of cellular processes. One of these is the maintenance of copper (Cu) homeostasis operated by the Golgi-localized Cu-transporting ATPases ATP7A and ATP7B.
Raffaella Petruzzelli +1 more
doaj +1 more source
Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour [PDF]
, 2016 The five-subunit WASH complex generates actin networks that participate in endocytic trafficking, migration and invasion in various cell types. Loss of one of the two subunits WASH or strumpellin in mice is lethal, but little is known about their role in
Insall, Robert H. +5 more
core +1 more source
PLoS Genetics, 2023 Copper (Cu) has a multifaceted role in brain development, function, and metabolism. Two homologous Cu transporters, Atp7a (Menkes disease protein) and Atp7b (Wilson disease protein), maintain Cu homeostasis in the tissue. Atp7a mediates Cu entry into the
Clorissa L Washington-Hughes +13 more
doaj +1 more source
Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis. [PDF]
, 2020 Copper levels are known to be elevated in inflamed and malignant tissues. But the mechanism underlying this selective enrichment has been elusive. In this study, we report a axis by which inflammatory cytokines, such as IL-17, drive cellular copper ...
Bao, Shideng +16 more
core
Metallochaperones regulate intracellular copper levels. [PDF]
, 2013 Copper (Cu) is an important enzyme co-factor that is also extremely toxic at high intracellular concentrations, making active efflux mechanisms essential for preventing Cu accumulation. Here, we have investigated the mechanistic role of metallochaperones
Adams, Michael +9 more
core +1 more source
Penicillamine increases free copper and enhances oxidative stress in the brain of toxic milk mice. [PDF]
PLoS ONE, 2012 Wilson disease (WD) is characterized by the accumulation of copper arising from a mutation in the ATP7B gene. Penicillamine (PA) makes 10-50% of the patients with neurologic symptoms neurologically worse at the early stage of administration.
Ding-Bang Chen +6 more
doaj +1 more source
A systematic review of genes involved in the inverse resistance relationship between cisplatin and paclitaxel chemotherapy: role of BRCA1 [PDF]
, 2009 A systematic review of cell models of acquired drug resistance not involving genetic manipulation showed that 80% of cell models had an inverse resistance relationship between cisplatin and paclitaxel[1].
Davey, Ross, Stordal, Britta
core +1 more source
Intragenic Deletions at Atp7a in Mouse Models for Menkes Disease
Genomics, 2001 Mottled mice have mutations in the copper-transporting ATPase Atp7a. They are proven models for the human disorder Menkes disease (MD), which results from mutations in a homologous gene. Mottled mice can be divided into three classes: class 1, in which affected males die before birth; class 2, in which affected males die in the early postnatal period ...
Thompson, Pamela +3 more
openaire +2 more sources
Therapeutic Targeting of ATP7B in Ovarian Carcinoma. [PDF]
, 2009 PURPOSE: Resistance to platinum chemotherapy remains a significant problem in ovarian carcinoma. Here, we examined the biological mechanisms and therapeutic potential of targeting a critical platinum resistance gene, ATP7B, using both in vitro and in ...
Armaiz-Pena, Guillermo N +20 more
core +1 more source