Results 41 to 50 of about 56,901 (159)

Biochemical Defects in Retina-specific Human ATP Binding Cassette Transporter Nucleotide Binding Domain 1 Mutants Associated with Macular Degeneration [PDF]

Journal of Biological Chemistry, 2002
The retina-specific human ABC transporter (ABCR) functions in the retinal transport system and has been implicated in several inherited visual diseases, including Stargardt disease, fundus flavimaculatus, cone-rod dystrophy, and age-related macular degeneration.
Tatiana, Suárez, Subhasis B, Biswas, Esther E, Biswas   +2 more
openaire   +2 more sources

Amentoflavone-Enriched Selaginella rossii Warb. Suppresses Body Weight and Hyperglycemia by Inhibiting Intestinal Lipid Absorption in Mice Fed a High-Fat Diet

Life, 2022
Many Selaginellaceae species are used as traditional medicines in Asia. This study is the first to investigate the anti-obesity and anti-diabetic effects of Selaginella rossii (SR) in high-fat diet (HFD)–fed C57BL/6J mice.
Hwa Lee, Seona Cho, Soo-Yong Kim, Jeongha Ju, Sang Woo Lee, Sangho Choi, Hulin Li, Renzhe Piao, Ho-Yong Park, Tae-Sook Jeong   +9 more
doaj   +1 more source

Generation of an urine-derived induced pluripotent stem cell line from a 6-year old X-linked adrenoleukodystrophy (X-ALD) patient

Stem Cell Research, 2021
The gene mutations of the ATP-binding-cassette transporter subfamily D member 1 (ABCD1) can lead to the inherited neuro-metabolic malfunction disease X-linked adrenoleukodystrophy (X-ALD).
Long Wang, Beibei Gao, Xuming Mo, Xiaoling Guo, Jinyu Huang   +4 more
doaj   +1 more source

In vivo modulation of HDL phospholipid has opposing effects on SR-BI- and ABCA1-mediated cholesterol efflux

Journal of Lipid Research, 2004
The effects of in vivo modulation of HDL phospholipid (PL) on scavenger receptor class BI (SR-BI)- and ATP binding cassette transporter 1 (ABCA1)-mediated efflux were examined by overexpressing either endothelial lipase (EL) or phosphatidylserine ...
Patricia G. Yancey, Masa-aki Kawashiri, Ryan Moore, Jane M. Glick, David L. Williams, Margery A. Connelly, Daniel J. Rader, George H. Rothblat   +7 more
doaj   +1 more source

ATP-Binding Cassette Transporter B4 Anchors the Cell Adhesion Molecule DdCAD-1 to Cell Membrane in Dictyostelium discoideum [PDF]

Indian Journal of Microbiology, 2013
In Dictyostelium, soluble cell adhesion molecule, DdCAD-1, regulates cell-cell interaction through an unknown anchoring protein on the plasma membrane. Far western blot analysis using different probes revealed that the potential DdCAD-1 interacting protein was between 64 and 98 kDa.
Chunxia, Yang, Liansheng, Hou, Qixiu, Yang, Chi-Hung, Siu   +3 more
openaire   +2 more sources

Isolation of an ABA Transporter-Like 1 Gene from Arachis hypogaea That Affects ABA Import and Reduces ABA Sensitivity in Arabidopsis

Frontiers in Plant Science, 2017
Abscisic acid (ABA) transporters are essential for the transport of ABA from its sites of synthesis to its multiple sites of action within plants and are key players in plant stress responses. Despite their importance, there is limited information on ABA
Kui Ge, Xing Liu, Xiaoyun Li, Bo Hu, Ling Li   +4 more
doaj   +1 more source

HIV-1 Protein Nef Inhibits Activity of ATP-binding Cassette Transporter A1 by Targeting Endoplasmic Reticulum Chaperone Calnexin [PDF]

Journal of Biological Chemistry, 2014
HIV-infected patients are at increased risk of developing atherosclerosis, in part due to an altered high density lipoprotein profile exacerbated by down-modulation and impairment of ATP-binding cassette transporter A1 (ABCA1) activity by the HIV-1 protein Nef. However, the mechanisms of this Nef effect remain unknown.
Lucas, Jennelle, Ruth, Hunegnaw, Larisa, Dubrovsky, Tatiana, Pushkarsky, Michael L, Fitzgerald, Dmitri, Sviridov, Anastas, Popratiloff, Beda, Brichacek, Michael, Bukrinsky   +8 more
openaire   +2 more sources

Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI

Journal of Lipid Research, 2012
To study the mechanisms of hepatic HDL formation, we investigated the roles of ABCA1, ABCG1, and SR-BI in nascent HDL formation in primary hepatocytes isolated from mice deficient in ABCA1, ABCG1, or SR-BI and from wild-type (WT) mice.
Ailing Ji, Joanne M. Wroblewski, Lei Cai, Maria C. de Beer, Nancy R. Webb, Deneys R. van der Westhuyzen   +5 more
doaj   +1 more source

Mechanistic insights of ABC importer HutCD involved in heme internalization by Vibrio cholerae

Scientific Reports, 2022
Heme internalization by pathogenic bacteria inside a human host to accomplish the requirement of iron for important cellular processes is of paramount importance.
Indrila Saha, Shrestha Chakraborty, Shubhangi Agarwal, Peeali Mukherjee, Biplab Ghosh, Jhimli Dasgupta   +5 more
doaj   +1 more source

Interferon-γ Induces Downregulation of Tangier Disease Gene (ATP-Binding-Cassette Transporter 1) in Macrophage-Derived Foam Cells [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2000
Abstract —Cholesterol efflux is a fundamental process that serves to mitigate cholesterol accumulation and macrophage foam cell formation. Recently, we reported that cholesterol efflux to high density lipoprotein subfraction 3 was reduced by interferon-γ (IFN-γ) and that this decrease was associated with an increase in acyl ...
C G, Panousis, S H, Zuckerman
openaire   +2 more sources