Results 51 to 60 of about 56,901 (159)

Associations of genetic polymorphisms of the transporters organic cation transporter 2 (OCT2), multidrug and toxin extrusion 1 (MATE1), and ATP-binding cassette subfamily C member 2 (ABCC2) with platinum-based chemotherapy response and toxicity in non-small cell lung cancer patients

Chinese Journal of Cancer, 2016
Background Platinum-based chemotherapy is the first-line treatment of non-small cell lung cancer (NSCLC); it is therefore important to discover biomarkers that can be used to predict the efficacy and toxicity of this treatment. Four important transporter
Chen-Yue Qian, Yi Zheng, Ying Wang, Juan Chen, Jun-Yan Liu, Hong-Hao Zhou, Ji-Ye Yin, Zhao-Qian Liu   +7 more
doaj   +1 more source

Structural insights into substrate recognition and translocation of human peroxisomal ABC transporter ALDP

Signal Transduction and Targeted Therapy, 2023
Dysfunctions of ATP-binding cassette, subfamily D, member 1 (ABCD1) cause X-linked adrenoleukodystrophy, a rare neurodegenerative disease that affects all human tissues. Residing in the peroxisome membrane, ABCD1 plays a role in the translocation of very
Chao Xiong, Li-Na Jia, Wei-Xi Xiong, Xin-Tong Wu, Liu-Lin Xiong, Ting-Hua Wang, Dong Zhou, Zhen Hong, Zheng Liu, Lin Tang   +9 more
doaj   +1 more source

ATP‐binding cassette transporter 1 (ABCA1) deficiency decreases platelet reactivity and reduces thromboxane A2 production independently of hematopoietic ABCA1 [PDF]

Journal of Thrombosis and Haemostasis, 2016
ESSENTIALS: The role of ATP-binding cassette transporter 1 (ABCA1) in platelet functions is poorly characterized. We studied the impact of ABCA1 deficiency on platelet responses in a mouse model and two Tangier patients. ABCA1-deficient platelets exhibit reduced positive feedback loop mechanisms.
Lhermusier, T., Severin, S., van Rothem, J., Garcia, C., Bertrand-Michel, Justine, Le Faouder, P., Hechler, B., Broccardo, C., Couvert, P., Chimini, G., Sie, P., Payrastre, Bernard   +11 more
openaire   +3 more sources

Cloning and expression of selected ABC transporters from the Arabidopsis thaliana ABCG family in Pichia pastoris.

PLoS ONE, 2019
Phytohormones play a major role in plant growth and development. They are in most cases not synthesized in their target location and hence need to be transported to the site of action, by for instance ATP-binding cassette transporters.
Katharina Gräfe, Kalpana Shanmugarajah, Thomas Zobel, Stefanie Weidtkamp-Peters, Diana Kleinschrodt, Sander H J Smits, Lutz Schmitt   +6 more
doaj   +1 more source

Generation of induced pluripotent stem cell (iPSC) line from a 21-year-old X-linked adrenoleukodystrophy (X-ALD) patient

Stem Cell Research, 2017
X-linked Adrenoleukodystrophy (X-ALD) is a genetic disease that caused by mutations in adenosine triphosphate [ATP]-binding-cassette transporter superfamily D member 1 (ABCD1) gene. We generated an induced pluripotent stem cell (iPSC) line from a 21-year-
Young Rang You, Daryeon Son, Phil Jun Kang, Seungkwon You, Dae-Sung Kim   +4 more
doaj   +1 more source

Influence of (ATP)-Binding Cassette Transporter Subfamily B Member 1 (ABCB1) Gene Polymorphism on the Efficacy of Remifentanil [PDF]

Medical Science Monitor, 2019
BACKGROUND The aim of this study was to investigate the influence of adenosine triphosphate (ATP)-binding cassette transporter subfamily B member 1 (ABCB1) gene polymorphism on the efficacy of Remifentanil. MATERIAL AND METHODS A total of 276 patients undergoing elective surgeries were included to collect general clinical information and detect the ...
Wang, Wenzhu, Zhou, Qinghua, Yuan, Changxiu   +2 more
openaire   +2 more sources

Current Status on Marine Products with Reversal Effect on Cancer Multidrug Resistance

Marine Drugs, 2012
The resistance of tumor cells to a broad range of anticancer agents continues to be a problem for the success of cancer chemotherapy. Multidrug resistance (MDR) is due in part to three drug transporter proteins: ABCB1/P-glycoprotein (P-gp), ABCC1 ...
Huiqin Guo, Zhe-Sheng Chen, Khalid El Sayed, Ioana Abraham   +3 more
doaj   +1 more source

Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette subfamily G member 2 [PDF]

American Journal of Physiology-Renal Physiology, 2017
Accumulating data indicate that renal uric acid (UA) handling is altered in diabetes and by hypoglycemic agents. In addition, hyperinsulinemia is associated with hyperuricemia and hypouricosuria. However, the underlying mechanisms remain unclear. In this study, we aimed to investigate how diabetes and hypoglycemic agents alter the levels of renal ...
Daigo, Toyoki, Shigeru, Shibata, Emiko, Kuribayashi-Okuma, Ning, Xu, Kenichi, Ishizawa, Makoto, Hosoyamada, Shunya, Uchida   +6 more
openaire   +2 more sources

Y-box binding protein-1 and STAT3 independently regulate ATP-binding cassette transporters in the chemoresistance of gastric cancer cells

International Journal of Oncology, 2018
Y-box binding protein-1 (YB-1) facilitates cancer chemoresistance through the upregulation of ATP-binding cassette (ABC) transporters associated with multidrug resistance, which is one of the primary obstacles in cancer treatment. Since aberrant Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling is also implicated in ...
Pei Jou, Chua, Jia Pei, Lim, Tian Tian, Guo, Puja, Khanna, Qidong, Hu, Boon Huat, Bay, Gyeong Hun, Baeg   +6 more
openaire   +3 more sources

Role of ATP-binding cassette transporter A1 in suppressing lipid accumulation by glucagon-like peptide-1 agonist in hepatocytes

Molecular Metabolism, 2020
Objective: Adenosine triphosphate (ATP)-binding cassette transporter A1 (ABCA1) influences hepatic cholesterol transportation. Accumulation of hepatic cholesterol leads to fatty liver disease, which is improved by glucagon-like peptide 1 (GLP-1) in ...
Jingya Lyu, Hitomi Imachi, Kensaku Fukunaga, Seisuke Sato, Toshihiro Kobayashi, Tao Dong, Takanobu Saheki, Mari Matsumoto, Hisakazu Iwama, Huanxiang Zhang, Koji Murao   +10 more
doaj   +1 more source