Results 1 to 10 of about 40,880 (280)

Bilirubin Decreases Macrophage Cholesterol Efflux and ATP‐Binding Cassette Transporter A1 Protein Expression [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background Mild but chronically elevated circulating unconjugated bilirubin is associated with reduced total and low‐density lipoprotein cholesterol concentration, which is associated with reduced cardiovascular disease risk.
Dongdong Wang, Anela Tosevska, Elke H. Heiß, Angela Ladurner, Christine Mölzer, Marlies Wallner, Andrew Bulmer, Karl‐Heinz Wagner, Verena M. Dirsch, Atanas G. Atanasov   +9 more
doaj   +8 more sources

Up-regulation of the ATP-binding cassette transporter A1 inhibits hepatitis C virus infection. [PDF]

PLoS ONE, 2014
Hepatitis C virus (HCV) establishes infection using host lipid metabolism pathways that are thus considered potential targets for indirect anti-HCV strategies.
Simone Bocchetta, Patrick Maillard, Mami Yamamoto, Claire Gondeau, Florian Douam, Stéphanie Lebreton, Sylvie Lagaye, Stanislas Pol, François Helle, Wanee Plengpanich, Maryse Guérin, Maryline Bourgine, Marie Louise Michel, Dimitri Lavillette, Philippe Roingeard, Wilfried le Goff, Agata Budkowska   +16 more
doaj   +22 more sources

Regulation of ATP binding cassette transporter A1 (ABCA1) expression: cholesterol-dependent and - independent signaling pathways with relevance to inflammatory lung disease. [PDF]

Respir Res, 2020
The role of the ATP binding cassette transporter A1 (ABCA1) in maintaining cellular lipid homeostasis in cardiovascular disease is well established. More recently, the important beneficial role played by ABCA1 in modulating pathogenic disease mechanisms,
He P, Gelissen IC, Ammit AJ.
europepmc   +4 more sources

ATP-binding cassette transporter A1: From metabolism to neurodegeneration [PDF]

Neurobiology of Disease, 2014
ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-free apolipoprotein A-I (apoA-I) and apolipoprotein E (apoE). ABCA1 is an essential regulator of high density lipoproteins (HDL) and reverse cholesterol transport — a role ...
Radosveta Koldamova, Nicholas F. Fitz, Iliya Lefterov   +2 more
doaj   +5 more sources

Preferential ATP-binding Cassette Transporter A1-mediated Cholesterol Efflux from Late Endosomes/Lysosomes [PDF]

Journal of Biological Chemistry, 2001
Recently, ATP-binding cassette transporter A1 (ABCA1), the defective molecule in Tangier disease, has been shown to stimulate phospholipid and cholesterol efflux to apolipoprotein A-I (apoA-I); however, little is known concerning the cellular cholesterol
Wengen Chen, Yu Sun, Carrie L. Welch, Anna Gorelik, Andrew Leventhal, Ira Tabas, Alan R. Tall   +6 more
semanticscholar   +5 more sources

Functional characterization of genetic variants affecting the intracellular domains of ATP-binding cassette transporter A1 (ABCA1) [PDF]

Journal of Lipid Research
The ATP-binding cassette transporter A1 (ABCA1) effluxes cellular cholesterol and phospholipids to extracellular acceptors, mainly apolipoprotein A1, generating high-density lipoprotein (HDL) particles.
Marianne Teigen, Åsa Schawlann Ølnes, Katrine Bjune, Martin Prøven Bogsrud, Thea Bismo Strøm   +4 more
doaj   +4 more sources

The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells. [PDF]

Nat Commun, 2017
Vγ9Vδ2 T cells are activated by phosphoantigens, such as isopentenyl pyrophosphate (IPP), which is generated in the mevalonate pathway of antigen-presenting cells. IPP is released in the extracellular microenvironment via unknown mechanisms. Here we show
Castella B, Kopecka J, Sciancalepore P, Mandili G, Foglietta M, Mitro N, Caruso D, Novelli F, Riganti C, Massaia M.   +9 more
europepmc   +2 more sources

MicroRNA-33-5p inhibits cholesterol efflux in vascular endothelial cells by regulating citrate synthase and ATP-binding cassette transporter A1. [PDF]

BMC Cardiovasc Disord, 2021
Background A high level of total cholesterol is associated with several lipid metabolism disorders, including atherosclerosis and cardiovascular diseases.
Xie Q, Peng J, Guo Y, Li F.
europepmc   +2 more sources

22R-Hydroxycholesterol and 9-cis-Retinoic Acid Induce ATP-binding Cassette Transporter A1 Expression and Cholesterol Efflux in Brain Cells and Decrease Amyloid β Secretion [PDF]

Journal of Biological Chemistry, 2003
The ATP-binding cassette transporter A1 (ABCA1) is a major regulator of peripheral cholesterol efflux and plasma high density lipoprotein metabolism. In adult rat brain we found high expression of ABCA1 in neurons in the hypothalamus, thalamus, amygdala,
Radosveta Koldamova, Iliya Lefterov, Miloš D. Ikonomović, John Skoko, Preslav Lefterov, Barbara A. Isanski, Steven T. DeKosky, John S. Lazo   +7 more
openalex   +2 more sources

ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses [PDF]

Lipids in Health and Disease, 2011
Objective The ATP-binding cassette transporter A1 (ABCA1) is essential protein involved in lipid metabolism. The present study was undertaken to detect the possible association of polymorphisms in the ABCA1 gene [rs2230806 (R219K) and rs2230808 (R1587K)]
Degiannis Dimitrios, Kalogiani Antonia, Vasilopoulos Georgios, Karakosta Agathi, Marvaki Apostolia, Kolovou Genovefa, Kolovou Vana, Marvaki Christina, Demopoulos Constantinos A   +8 more
doaj   +2 more sources