Results 1 to 10 of about 27,689 (174)

ATP-binding cassette transporter A1: From metabolism to neurodegeneration [PDF]

Neurobiology of Disease, 2014
ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-free apolipoprotein A-I (apoA-I) and apolipoprotein E (apoE). ABCA1 is an essential regulator of high density lipoproteins (HDL) and reverse cholesterol transport — a role ...
Radosveta Koldamova, Nicholas F. Fitz, Iliya Lefterov   +2 more
doaj   +6 more sources

Bilirubin Decreases Macrophage Cholesterol Efflux and ATP‐Binding Cassette Transporter A1 Protein Expression [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background Mild but chronically elevated circulating unconjugated bilirubin is associated with reduced total and low‐density lipoprotein cholesterol concentration, which is associated with reduced cardiovascular disease risk.
Dongdong Wang, Anela Tosevska, Elke H. Heiß, Angela Ladurner, Christine Mölzer, Marlies Wallner, Andrew Bulmer, Karl‐Heinz Wagner, Verena M. Dirsch, Atanas G. Atanasov   +9 more
doaj   +7 more sources

The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration. [PDF]

Biochim Biophys Acta, 2010
ATP-binding cassette transporter A1 - ABCA1, is the most extensively studied transporter in human pathology. ABCA1 became a primary subject of research in many academic and pharmaceutical laboratories immediately after the discovery that mutations at the gene locus cause severe familial High Density Lipoprotein (HDL) deficiency and, in the homozygous ...
Koldamova R, Fitz NF, Lefterov I.
europepmc   +5 more sources

Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity. [PDF]

Arterioscler Thromb Vasc Biol, 2018
Objective— Adipose tissue cholesterol increases with adipocyte triglyceride content and size during development of obesity. However, how adipocyte cholesterol affects adipocyte function is poorly understood. The aim of this study was to evaluate the role of the cellular cholesterol exporter, Abca1 (ATP-binding cassette ...
Cuffe H, Liu M, Key CC, Boudyguina E, Sawyer JK, Weckerle A, Bashore A, Fried SK, Chung S, Parks JS.   +9 more
europepmc   +5 more sources

Up-regulation of the ATP-binding cassette transporter A1 inhibits hepatitis C virus infection. [PDF]

PLoS ONE, 2014
Hepatitis C virus (HCV) establishes infection using host lipid metabolism pathways that are thus considered potential targets for indirect anti-HCV strategies.
Simone Bocchetta, Patrick Maillard, Mami Yamamoto, Claire Gondeau, Florian Douam, Stéphanie Lebreton, Sylvie Lagaye, Stanislas Pol, François Helle, Wanee Plengpanich, Maryse Guérin, Maryline Bourgine, Marie Louise Michel, Dimitri Lavillette, Philippe Roingeard, Wilfried le Goff, Agata Budkowska   +16 more
doaj   +6 more sources

Regulation of ATP binding cassette transporter A1 (ABCA1) expression: cholesterol-dependent and - independent signaling pathways with relevance to inflammatory lung disease. [PDF]

Respir Res, 2020
The role of the ATP binding cassette transporter A1 (ABCA1) in maintaining cellular lipid homeostasis in cardiovascular disease is well established. More recently, the important beneficial role played by ABCA1 in modulating pathogenic disease mechanisms,
He P, Gelissen IC, Ammit AJ.
europepmc   +2 more sources

The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells. [PDF]

Nat Commun, 2017
Vγ9Vδ2 T cells are activated by phosphoantigens, such as isopentenyl pyrophosphate (IPP), which is generated in the mevalonate pathway of antigen-presenting cells. IPP is released in the extracellular microenvironment via unknown mechanisms. Here we show
Castella B, Kopecka J, Sciancalepore P, Mandili G, Foglietta M, Mitro N, Caruso D, Novelli F, Riganti C, Massaia M.   +9 more
europepmc   +2 more sources

ATP-binding Cassette Transporter A1 (ABCA1) Functions as a Cholesterol Efflux Regulatory Protein* [PDF]

Journal of Biological Chemistry, 2001
ABCA1, an ATP-binding cassette transporter mutated in Tangier disease, promotes cellular phospholipid and cholesterol efflux by loading free apoA-I with these lipids. This process involves binding of apoA-I to the cell surface and phospholipid translocation by ABCA1.
Nan Wang, D. Silver, C. Thiele, A. Tall
semanticscholar   +3 more sources

ATP-binding cassette transporter A1 expression is decreased in preeclamptic placentas. [PDF]

Reprod Sci, 2013
Preeclampsia is a pregnancy-specific multisystem disorder characterized by hypertension and proteinuria. Accentuated maternal hyperlipidemia, especially high serum levels of oxidized low-density lipoprotein (oxLDL), is one of the features of preeclampsia.
Chigusa Y, Kondoh E, Mogami H, Nishimura F, Ujita M, Kawasaki K, Fujita K, Tatsumi K, Konishi I.   +8 more
europepmc   +4 more sources

Role of ATP-binding cassette transporter A1 in suppressing lipid accumulation by glucagon-like peptide-1 agonist in hepatocytes. [PDF]

Mol Metab, 2020
Objective Adenosine triphosphate (ATP)-binding cassette transporter A1 (ABCA1) influences hepatic cholesterol transportation. Accumulation of hepatic cholesterol leads to fatty liver disease, which is improved by glucagon-like peptide 1 (GLP-1) in ...
Lyu J, Imachi H, Fukunaga K, Sato S, Kobayashi T, Dong T, Saheki T, Matsumoto M, Iwama H, Zhang H, Murao K.   +10 more
europepmc   +2 more sources