Results 101 to 110 of about 27,747 (231)

Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathwayss⃞

Journal of Lipid Research, 2007
Endocytosis of LDL and modified LDL represents regulated and unregulated cholesterol delivery to macrophages. To elucidate the mechanisms of cellular cholesterol transport and egress under both conditions, various primary macrophages were labeled and ...
Ming-Dong Wang, Robert S. Kiss, Vivian Franklin, Heidi M. McBride, Stewart C. Whitman, Yves L. Marcel   +5 more
doaj   +1 more source

The Central Helices of ApoA-I Can Promote ATP-binding Cassette Transporter A1 (ABCA1)-mediated Lipid Efflux

Journal of Biological Chemistry, 2003
We have mapped the domains of lipid-free apoA-I that promote cAMP-dependent and cAMP-independent cholesterol and phospholipid efflux. The cAMP-dependent lipid efflux in J774 mouse macrophages was decreased by ∼80–92% by apoA-I[Δ(185–243)], only by 15% by
A. Chroni, Tong Liu, I. Gorshkova, Horng-Yuan Kan, Y. Uehara, A. von Eckardstein, V. Zannis   +6 more
semanticscholar   +1 more source

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu, Junhong Yao, Jiaxin Deng, Minjie Zhou, Kaiyue Shen, Shishuo Sun, Xiaoge Gao, Qing Zhang, Haiheng Xu   +8 more
wiley   +1 more source

Photobiomodulation therapy promotes the ATP-binding cassette transporter A1-dependent cholesterol efflux in macrophage to ameliorate atherosclerosis. [PDF]

J Cell Mol Med, 2021
Yin Q, Chang H, Shen Q, Xing D.
europepmc   +1 more source

Astaxanthin Enhances ATP-Binding Cassette Transporter A1/G1 Expressions and Cholesterol Efflux from Macrophages

Journal of Nutritional Science and Vitaminology, 2012
ATP-binding cassette transporters (ABC) A1 and G1 are key molecules in cholesterol efflux from macrophages, which is an initial step of reverse cholesterol transport (RCT), a major anti-atherogenic property of high-density lipoprotein (HDL). Astaxanthin is one of the naturally occurring carotenoids responsible for the pink-red pigmentation in a variety
Maki, Iizuka, Makoto, Ayaori, Harumi, Uto-Kondo, Emi, Yakushiji, Shunichi, Takiguchi, Kazuhiro, Nakaya, Tetsuya, Hisada, Makoto, Sasaki, Tomohiro, Komatsu, Makiko, Yogo, Yoshimi, Kishimoto, Kazuo, Kondo, Katsunori, Ikewaki   +12 more
openaire   +3 more sources

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, Volume 13, Issue 16, 18 March 2026.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

ABCA1 promotes the efflux of bacterial LPS from macrophages and accelerates recovery from LPS-induced tolerance[S]

Journal of Lipid Research, 2010
Macrophages play important roles in both lipid metabolism and innate immunity. We show here that macrophage ATP-binding cassette transporter A1 (ABCA1), a transporter known for its ability to promote apolipoprotein-dependent cholesterol efflux, also ...
Patricia A. Thompson, Karine C. Gauthier, Alan W. Varley, Richard L. Kitchens   +3 more
doaj   +1 more source

A Common R219K Variant of ATP-Binding Cassette Transporter A1 Gene Alters Atherometabolic Traits in Pregnant Women With Gestational Diabetes Mellitus. [PDF]

Front Endocrinol (Lausanne), 2021
Tang F, Guan L, Liu X, Fan P, Zhou M, Wu Y, Liu R, Liu Y, Liu S, Li D, Bai H.   +10 more
europepmc   +1 more source

The spleen–brain axis in Alzheimer's disease and related dementias: Integrating immune and metabolic regulation

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Emerging evidence highlights the central role of peripheral immune–metabolic regulation in the pathogenesis of Alzheimer's disease and related dementias (ADRD). Among peripheral organs, the spleen has gained increasing attention as a critical immune–metabolic hub linking systemic homeostasis to central neurodegeneration.
Jingsi Yan, Jiayu Zhang, Xinyi Ye, Huihong Wang, Hang Li, Weirong Li, Huifei Wu, Wei Zhao   +7 more
wiley   +1 more source

Lipid efflux in human and mouse macrophagic cells: evidence for differential regulation of phospholipid and cholesterol efflux

Journal of Lipid Research, 2005
ABCA1 is a critical regulator of lipid efflux from cells, which is highly regulated at the transcriptional and posttranslational levels. However, cells from different species and different tissues, and primary versus immortalized cells, show different ...
Robert S. Kiss, Jovana Maric, Yves L. Marcel   +2 more
doaj   +1 more source