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Dynamic regulation of alternative ATP-binding cassette transporter A1 transcripts
Biochemical and Biophysical Research Communications, 2003The ATP-binding cassette transporter A1 (ABCA1) gene, a major regulator of high-density lipoprotein (HDL) metabolism, utilizes several transcriptional start sites. The pattern of transcripts among tissues and cells differed significantly. The longest (class 1) transcripts were abundant in adult brain and fetal tissues.
Jarkko, Huuskonen +7 more
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ATP-binding cassette transporter A1 and cholesterol trafficking
Current Opinion in Lipidology, 2002Two hallmarks of cardiovascular disease are the presence of sterol-laden macrophages in the artery wall and reduced plasma HDL levels. A cell membrane protein named ATP-binding cassette transporter A1 (ABCA1) mediates secretion of excess cholesterol from cells into the HDL metabolic pathway.
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The expression of ATP-binding cassette transporter A1 in Chinese overweight and obese patients
International Journal of Obesity, 2009ATP-binding cassette transporters (ABCA1, ABCG1) and scavenger receptor class B type I (SR-BI) are the three most important cellular cholesterol transporters/receptor in regulating cholesterol efflux. We have investigated whether the expression of these transporters/receptor is altered in overweight and obese patients, and the potential association ...
M, Xu, H, Zhou, J, Wang, C, Li, Y, Yu
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ATP-binding cassette transporter A1: regulation of cholesterol efflux
Biochemical Society Transactions, 2004The ATP-binding cassette transporter A1 (ABCA1) is involved in the regulation of cholesterol efflux from cells. Mutations in ABCA1 give rise to familial high-density lipoprotein (HDL) deficiency and Tangier disease, which is characterized by very low levels of HDL in plasma and cholesteryl ester accumulation in tonsils and other reticuloendothelial ...
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The Role of Different Regions of ATP-Binding Cassette Transporter A1 in Cholesterol Efflux
Biochemistry, 2007ABCA1 is a key element of cholesterol efflux, but the mechanism of ABCA1-dependent cholesterol efflux is still unclear. Monoclonal antibodies against ABCA1 were used to map functional domains of ABCA1. Two antibodies were directed against a fragment of the first extracellular loop of ABCA1, and the third antibody was directed against a fragment of the ...
Nigora, Mukhamedova +4 more
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Regulation of ATP-Binding Cassette Transporter A1 Transcription by Thyroid Hormone Receptor
Biochemistry, 2004Transcriptional regulation of the ATP-binding cassette transporter (ABCA1) gene is complex. It involves multiple transcription start sites and the binding of several different transcription factors to the ABCA1 promoter region. Cholesterol- and oxysterol-mediated up-regulation of ABCA1 transcription includes the binding of the liver X receptor and ...
Jarkko, Huuskonen +4 more
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ATP-binding cassette transporter A1, fatty acids, and cholesterol absorption
Current Opinion in Lipidology, 2003A significant advance in our understanding of the reverse cholesterol transport pathway occurred in 1999 with the identification of defects in the ATP-binding cassette transporter A1 gene as the cause of Tangier disease. Since this discovery, an overwhelming number of experiments have been conducted to further define the function of this gene.
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ATP-binding cassette transporter A1
Current Opinion in Lipidology, 2014ATP-binding cassette transporter A1 (ABCA1) facilitates cellular cholesterol efflux to lipid-poor apolipoprotein AI (apoAI) and plays a key role in the formation and function of HDL. This review summarizes the advances and new insights in the role of ABCA1 in cardiovascular and metabolic diseases from studies in genetically engineered mice.Recent ...
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ATP-Binding cassette transporter A1 is involved in hepatic α-tocopherol secretion
The Journal of Nutritional Biochemistry, 2010Vitamin E (alpha-tocopherol) is an essential fat-soluble nutrient with antioxidant properties. alpha-Tocopherol transfer protein (alpha-TTP), the product of the gene responsible for familial isolated vitamin E deficiency, plays an important role in maintaining the plasma alpha-tocopherol level by mediating the secretion of alpha-tocopherol by the liver.
Mototada, Shichiri +7 more
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The role of the ATP-binding cassette transporter A1 (ABCA1) in cholesterol metabolism
2021The release of cellular cholesterol and phospholipid to apolipoproteins is thought to be the initial step in high density lipoprotein (HDL) formation. HDL is the lipid carrier of reverse cholesterol transport (RCT), the process by which cholesterol is mobilized from the periphery.
Anna E. Bortnick, George H. Rothblat
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