Results 11 to 20 of about 27,747 (231)

ATP-binding cassette transporter A1: A promising therapy target for prostate cancer. [PDF]

Mol Clin Oncol, 2018
ATP-binding cassette transporter A1 (ABCA1) has been found to mediate the transfer of cellular cholesterol across the plasma membrane to apolipoprotein A-I (apoA-I), and is essential for the synthesis of high-density lipoprotein. Mutations of the ABCA1 gene may induce Tangier disease and familial hypoalphalipoproteinemia; they may also lead to loss of ...
Xiong T, Xu G, Huang XL, Lu KQ, Xie WQ, Yin K, Tu J.   +6 more
europepmc   +4 more sources

ATP-binding Cassette Transporter A1 Mediates Cellular Secretion of α-Tocopherol* [PDF]

Journal of Biological Chemistry, 2001
α-Tocopherol (α-TOH) is associated with plasma lipoproteins and accumulates in cell membranes throughout the body, suggesting that lipoproteins play a role in transporting α-TOH between tissues. Here we show that secretion of α-TOH from cultured cells is
J. Oram, A. Vaughan, R. Stocker
semanticscholar   +3 more sources

Preferential ATP-binding Cassette Transporter A1-mediated Cholesterol Efflux from Late Endosomes/Lysosomes* [PDF]

Journal of Biological Chemistry, 2001
Recently, ATP-binding cassette transporter A1 (ABCA1), the defective molecule in Tangier disease, has been shown to stimulate phospholipid and cholesterol efflux to apolipoprotein A-I (apoA-I); however, little is known concerning the cellular cholesterol
Wengen Chen, Yu Sun, Carrie M. Welch, Anna Gorelik, Andrew R. Leventhal, I. Tabas, A. Tall   +6 more
semanticscholar   +3 more sources

Functional characterization of genetic variants affecting the intracellular domains of ATP-binding cassette transporter A1 (ABCA1) [PDF]

Journal of Lipid Research
The ATP-binding cassette transporter A1 (ABCA1) effluxes cellular cholesterol and phospholipids to extracellular acceptors, mainly apolipoprotein A1, generating high-density lipoprotein (HDL) particles.
Marianne Teigen, Åsa Schawlann Ølnes, Katrine Bjune, Martin Prøven Bogsrud, Thea Bismo Strøm   +4 more
doaj   +2 more sources

A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression. [PDF]

PLoS ONE, 2011
Despite the well known importance of apolipoprotein (Apo) E in cholesterol efflux, the effect of ApoE on the expression of ATP-binding cassette transporter A1 (ABCA1) has never been investigated. The objective of this study was to determine the effect of
Yanfeng Zhao, Xinping Chen, Hong Yang, Lichun Zhou, Emmanuel U Okoro, Zhongmao Guo   +5 more
doaj   +2 more sources

ATP-binding cassette transporter A1 (ABCA1) expression in adipose tissue and its modulation with insulin resistance in obesity [PDF]

Diabetes, Metabolic Syndrome and Obesity, 2019
Vinnyfred Vincent,1 Himani Thakkar,1 Sandeep Aggarwal,2 Asit Ranjan Mridha,3 Lakshmy Ramakrishnan,4 Archna Singh1 1Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India; 2Department of Surgical Disciplines, All India ...
Vincent V, Thakkar H, Aggarwal S, Mridha AR, Ramakrishnan L, Singh A   +5 more
doaj   +2 more sources

Palmitoylation of ATP-Binding Cassette Transporter A1 Is Essential for Its Trafficking and Function [PDF]

Circulation Research, 2009
ATP-binding cassette transporter (ABC)A1 lipidates apolipoprotein A-I both directly at the plasma membrane and also uses lipids from the late endosomal or lysosomal compartment in the internal lipidation of apolipoprotein A-I. However, how ABCA1 targeting to these specific membranes is regulated remains unknown.
Roshni R, Singaraja, Martin H, Kang, Kuljeet, Vaid, Shaun S, Sanders, Gonzalo L, Vilas, Pamela, Arstikaitis, Jonathan, Coutinho, Renaldo C, Drisdel, Alaa El Din, El-Husseini, William N, Green, Luc, Berthiaume, Michael R, Hayden   +11 more
openaire   +4 more sources

Association of ATP-Binding Cassette Transporter A1 Gene Polymorphisms in Type 2 Diabetes Mellitus among Malaysians [PDF]

Journal of Diabetes Research, 2015
Background. Type 2 diabetes mellitus (T2DM) is a complex polygenic disorder characterized by impaired insulin resistance, insulin secretion, and dysregulation of lipid and protein metabolism with environmental and genetic factors.
Polin Haghvirdizadeh, Vasudevan Ramachandran, Ali Etemad, Farzad Heidari, Nooshin Ghodsian, Norzian Bin Ismail, Patimah Ismail   +6 more
doaj   +2 more sources

Transcriptional regulation of ATP-binding cassette transporter A1 expression by a novel signaling pathway. [PDF]

J Biol Chem, 2011
ATP-binding cassette transporter A1 (ABCA1) is a membrane-bound protein that regulates the efflux of cholesterol derived from internalized lipoproteins. Using a mouse macrophage cell line, this report studied the impact of low-density lipoproteins (LDL) on ABCA1 expression and the signaling pathway responsible for lipoprotein-induced ABCA1 expression ...
Chen X, Zhao Y, Guo Z, Zhou L, Okoro EU, Yang H.   +5 more
europepmc   +4 more sources

ABCA1 is an extracellular phospholipid translocase

Nature Communications, 2022
ATP-binding cassette transporter A1 (ABCA1) drives phospholipid (PL) from the plasma membrane into extracellular apolipoprotein A-I, for the production of high density lipoprotein (HDL).
Jere P. Segrest, Chongren Tang, Hyun D. Song, Martin K. Jones, W. Sean Davidson, Stephen G. Aller, Jay W. Heinecke   +6 more
doaj   +1 more source