Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity. [PDF]
Arterioscler Thromb Vasc Biol, 2018 Objective— Adipose tissue cholesterol increases with adipocyte triglyceride content and size during development of obesity. However, how adipocyte cholesterol affects adipocyte function is poorly understood. The aim of this study was to evaluate the role of the cellular cholesterol exporter, Abca1 (ATP-binding cassette ...
Cuffe H +9 more
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Depletion of Pre-β-high Density Lipoprotein by Human Chymase Impairs ATP-binding Cassette Transporter A1- but Not Scavenger Receptor Class B Type I-mediated Lipid Efflux to High Density Lipoprotein [PDF]
Journal of Biological Chemistry, 2004 The ATP-binding cassette transporter A1 (ABCA1) mediates the efflux of cellular unesterified cholesterol and phospholipid to lipid-poor apolipoprotein A-I.
Elda Favari +6 more
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A Common R219K Variant of ATP-Binding Cassette Transporter A1 Gene Alters Atherometabolic Traits in Pregnant Women With Gestational Diabetes Mellitus. [PDF]
Front Endocrinol (Lausanne), 2021 Tang F +10 more
europepmc +3 more sources
Effects of Apolipoprotein A-I on ATP-binding Cassette Transporter A1-mediated Efflux of Macrophage Phospholipid and Cholesterol [PDF]
Journal of Biological Chemistry, 2003 The mechanism of formation of high density lipoprotein (HDL) particles by the action of ATP-binding cassette transporter A1 (ABCA1) is not defined completely. To address this issue, we monitored efflux to apoA-I of phosphatidylcholine (PC), sphingomyelin
Lijuan Liu +7 more
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ATP-binding Cassette Transporter A1 Mediates Cellular Secretion of α-Tocopherol* [PDF]
Journal of Biological Chemistry, 2001 α-Tocopherol (α-TOH) is associated with plasma lipoproteins and accumulates in cell membranes throughout the body, suggesting that lipoproteins play a role in transporting α-TOH between tissues. Here we show that secretion of α-TOH from cultured cells is
J. Oram, A. Vaughan, R. Stocker
semanticscholar +3 more sources
A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression. [PDF]
PLoS ONE, 2011 Despite the well known importance of apolipoprotein (Apo) E in cholesterol efflux, the effect of ApoE on the expression of ATP-binding cassette transporter A1 (ABCA1) has never been investigated. The objective of this study was to determine the effect of
Yanfeng Zhao +5 more
doaj +2 more sources
PLoS ONE, 2011 Objective Increasing plasma glucose levels are associated with increasing risk of vascular disease. We tested the hypothesis that there is a glycaemia-mediated impairment of reverse cholesterol transport (RCT).
Dipesh Patel +8 more
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ATP-binding cassette transporter A1 (ABCA1) expression in adipose tissue and its modulation with insulin resistance in obesity [PDF]
Diabetes, Metabolic Syndrome and Obesity, 2019 Vinnyfred Vincent,1 Himani Thakkar,1 Sandeep Aggarwal,2 Asit Ranjan Mridha,3 Lakshmy Ramakrishnan,4 Archna Singh1 1Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India; 2Department of Surgical Disciplines, All India ...
Vincent V +5 more
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ATP-binding Cassette Transporter A1 Contains an NH2-terminal Signal Anchor Sequence That Translocates the Protein's First Hydrophilic Domain to the Exoplasmic Space [PDF]
Journal of Biological Chemistry, 2001 Mutations in the ATP-binding cassette transporter A1 (ABCA1) transporter are associated with Tangier disease and a defect in cellular cholesterol efflux.
Michael L. Fitzgerald +5 more
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Journal of Biological Chemistry, 2010 The cholesterol transpoter ATP-binding cassette transporter A1 (ABCA1) moves lipids onto apolipoproteins including apolipoprotein E (apoE), which is the major cholesterol carrier in the brain and an established genetic risk factor for late-onset ...
James Donkin +9 more
openalex +2 more sources