Results 41 to 50 of about 27,747 (231)

Perivascular Adipose-Derived Exosomes Reduce Foam Cell Formation by Regulating Expression of Cholesterol Transporters

Frontiers in Cardiovascular Medicine, 2021
Background: Accumulating evidence demonstrates that perivascular adipose tissue (PVAT) plays an important role in maintaining vascular homeostasis. The formation of macrophage foam cells is a central feature of atherosclerosis.
Yan Liu, Yan Sun, Xuze Lin, Dai Zhang, Chengping Hu, Jinxing Liu, Yong Zhu, Ang Gao, Hongya Han, Meng Chai, Jianwei Zhang, Yujie Zhou, Yingxin Zhao   +12 more
doaj   +1 more source

Pitavastatin Increases ABCA1 Expression by Dual Mechanisms: SREBP2-Driven Transcriptional Activation and PPARα-Dependent Protein Stabilization but Without Activating LXR in Rat Hepatoma McARH7777 Cells

Journal of Pharmacological Sciences, 2011
.: Hepatic ATP-binding cassette transporter A1 (ABCA1) plays a key role in high-density lipoprotein (HDL) production by apolipoprotein A-I (ApoA-I) lipidation.
Takashi Maejima, Tomohiro Sugano, Hiroyuki Yamazaki, Yasunobu Yoshinaka, Takeshi Doi, Sohei Tanabe, Tomoko Nishimaki-Mogami   +6 more
doaj   +1 more source

New Strategies to Promote Macrophage Cholesterol Efflux

Frontiers in Cardiovascular Medicine, 2021
The capacity of macrophages to dispose of cholesterol deposited in the atherosclerotic plaque depends on their ability to activate cholesterol efflux pathways.
Hong Y. Choi, Isabelle Ruel, Shiwon Choi, Jacques Genest   +3 more
doaj   +1 more source

ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice*

Journal of Biological Chemistry, 2010
The cholesterol transpoter ATP-binding cassette transporter A1 (ABCA1) moves lipids onto apolipoproteins including apolipoprotein E (apoE), which is the major cholesterol carrier in the brain and an established genetic risk factor for late-onset ...
J. Donkin, S. Stukas, V. Hirsch-Reinshagen, Dhananjay R. Namjoshi, Anna Wilkinson, Sharon May, Jeniffer Y. Chan, Jianjia Fan, Jon L. Collins, C. Wellington   +9 more
semanticscholar   +1 more source

Identification of an ABCA1-dependent phospholipid-rich plasma membrane apolipoprotein A-I binding site for nascent HDL formation: implications for current models of HDL biogenesis

Journal of Lipid Research, 2007
It is well accepted that both apolipoprotein A-I (apoA-I) and ABCA1 play crucial roles in HDL biogenesis and in the human atheroprotective system. However, the nature and specifics of apoA-I/ABCA1 interactions remain poorly understood.
Houssein Hajj Hassan, Maxime Denis, Dong-Young Donna Lee, Iulia Iatan, Dana Nyholt, Isabelle Ruel, Larbi Krimbou, Jacques Genest   +7 more
doaj   +1 more source

Janus kinase 2 modulates the lipid-removing but not protein-stabilizing interactions of amphipathic helices with ABCA1

Journal of Lipid Research, 2006
ABCA1 mediates the transport of cellular cholesterol and phospholipids to HDL apolipoproteins. Apolipoprotein A-I (apoA-I) interactions with ABCA1-expressing cells elicit several responses, including removing cellular lipids, stabilizing ABCA1 protein ...
Chongren Tang, Ashley M. Vaughan, G.M. Anantharamaiah, John F. Oram   +3 more
doaj   +1 more source

22R-Hydroxycholesterol and 9-cis-Retinoic Acid Induce ATP-binding Cassette Transporter A1 Expression and Cholesterol Efflux in Brain Cells and Decrease Amyloid β Secretion*

Journal of Biological Chemistry, 2003
The ATP-binding cassette transporter A1 (ABCA1) is a major regulator of peripheral cholesterol efflux and plasma high density lipoprotein metabolism. In adult rat brain we found high expression of ABCA1 in neurons in the hypothalamus, thalamus, amygdala,
R. Koldamova, I. Lefterov, M. Ikonomovic, J. Skoko, Preslav I. Lefterov, Barbara A. Isanski, S. DeKosky, J. Lazo   +7 more
semanticscholar   +1 more source

Chalcone Derivatives Enhance ATP-Binding Cassette Transporters A1 in Human THP-1 Macrophages [PDF]

Molecules, 2018
Atherosclerosis is a process of imbalanced lipid metabolism in the vascular walls. The underlying pathology mainly involves the deposition of oxidized lipids in the endothelium and the accumulation of cholesterol in macrophages. Macrophages export excessive cholesterol (cholesterol efflux) through ATP-binding cassette transporter A1 (ABCA1) to counter ...
Teng, I-Jou, Tsai, Min-Chien, Shih, Shao-Fu, Tsuei, Bi-Feng, Chang, Hsin, Chuang, Yi-Ping, Lin, Chin-Sheng, Chern, Ching-Yuh, Chen, Sy-Jou   +8 more
openaire   +3 more sources

Common ABCA1 variants, HDL levels, and cellular cholesterol efflux in subjects with familial low HDLs⃞

Journal of Lipid Research, 2007
HDL promotes cholesterol efflux from peripheral cells via ABCA1 in the first step of reverse cholesterol transport (RCT). We investigated whether the early steps of RCT were disturbed in subjects with familial low HDL and an increased risk for early ...
Aino Soro-Paavonen, Jussi Naukkarinen, Miriam Lee-Rueckert, Hiroshi Watanabe, Elina Rantala, Sanni Soderlund, Anne Hiukka, Petri T. Kovanen, Matti Jauhiainen, Leena Peltonen, Marja-Riitta Taskinen   +10 more
doaj   +1 more source

MEDI6012: Recombinant Human Lecithin Cholesterol Acyltransferase, High‐Density Lipoprotein, and Low‐Density Lipoprotein Receptor–Mediated Reverse Cholesterol Transport

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background MEDI6012 is recombinant human lecithin cholesterol acyltransferase, the rate‐limiting enzyme in reverse cholesterol transport. Infusions of lecithin cholesterol acyltransferase have the potential to enhance reverse cholesterol transport and ...
Richard T. George, Liron Abuhatzira, Susan M. Stoughton, Sotirios K. Karathanasis, Dewei She, ChaoYu Jin, Nicholas A. P. S. Buss, Rebecca Bakker‐Arkema, Emily L. Ongstad, Michael Koren, Boaz Hirshberg   +10 more
doaj   +1 more source