Results 121 to 130 of about 2,375 (156)

Selected Nutraceuticals in Metabolic Syndrome: Molecular Mechanisms and Clinical Implications. [PDF]

Biomedicines
Starvaggi J, Di Chio C, De Luca F, Previti S, Zappalà M, Ettari R.   +5 more
europepmc   +1 more source

Diet-induced Lipid Accumulation in Liver Enhances ATP-binding Cassette Transporter g5/g8 Expression in Bile Canaliculi

Drug Metabolism and Pharmacokinetics, 2011
The ATP-binding cassette half-transporters Abcg5 and Abcg8 promote the secretion of neutral sterols into bile. Studies have demonstrated the diet-induced expression of these transporters in liver, but precisely where this occurs remains to be elucidated.
Yasuhiro Yamazaki, Takahiro Hashizume, Hiroko Morioka, Satoshi Sadamitsu, Akira Ikari, Masao Miwa, Junko Sugatani   +6 more
openalex   +3 more sources

Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice

Journal of Hepatology, 2003
Mutations in genes encoding the ATP-binding cassette (ABC)-transporters ABCG5 and ABCG8 underlie sitosterolemia, which is characterized by elevated plasma levels of phytosterols due to increased intestinal absorption and impaired biliary secretion of sterols.
Astrid Kosters, Raoul Frijters, Frank G. Schaap, Edwin Vink, Torsten Plösch, Roelof Ottenhoff, M Jirsa, Iris M. De Cuyper, Folkert Kuipers, Albert K. Groen   +9 more
openalex   +5 more sources

Inhibition of Ceramide Decreased the Expression of ATP-Binding Cassette Transporter G5/8 mRNA in an Animal Model of Cholesterol Gallstone

Digestive Diseases, 2017
<b><i>Background:</i></b> The increased risk of gallstone has been reported in patients with ATP-binding cassette (ABC) transporter polymorphism. The half-transporters ABCG5 and ABCG8 mediate the efflux of cholesterol in hepatocytes and the intestine.
Hyo Jung Kim, Jae Seon Kim, Seikwan Oh, Hwan‐Soo Yoo   +3 more
openalex   +3 more sources

Scavenger Receptor Class B Type I Mediates Biliary Cholesterol Secretion Independent of ATP-Binding Cassette Transporter g5/g8 in Mice†

Hepatology, 2009
Scavenger receptor class B type I (SR-BI) mediates selective uptake of cholesterol from high-density lipoprotein (HDL) particles by the liver and influences biliary cholesterol secretion. However, it is not clear, if this effect is direct or indirect.
Harmen Wiersma, Alberto Gatti, Niels Nijstad, Ronald P.J. Oude Elferink, Folkert Kuipers, Uwe J.F. Tietge   +5 more
openalex   +3 more sources

Lymphatic Absorption and Deposition of Various Plant Sterols in Stroke‐Prone Spontaneously Hypertensive Rats, a Strain Having a Mutation in ATP binding cassette transporter G5

Lipids, 2007
AbstractATP binding cassette transporter G5 (ABCG5) and ATP binding cassette transporter G8 (ABCG8) have been suggested to transport absorbed plant sterols and cholesterol from enterocytes to the intestinal lumen and from hepatocytes to bile. It has been thought that mutations of ABCG5 or ABCG8 cause the deposition of plant sterols in the body.
Tadateru Hamada, Nami Egashira, Shoko Nishizono, Hiroko Tomoyori, Hideaki Nakagiri, Katsumi Imaizumi, Ikuo Ikeda   +6 more
openalex   +3 more sources

2P-0450 Identification of a novel mutation in the ATP-binding cassette transporter G5 (ABCG5) in a Japanese patient with sitosterolemia

Atherosclerosis Supplements, 2003
Masahiro Koseki, A. Matsuyama, Masato Ishigami, Katsuya Hirano, Naohiko Sakai, H. Hiraoka, Taro Nakamura, Hiroyoshi Hattori, Minoru Nagano, Toru Egashira, S. Yamashita, Yūji Matsuzawa   +11 more
openalex   +2 more sources

Cyclosporine A Reduces ATP-Binding Cassette Transporter G5 (ABCG5) and G8 (ABCG8) Gene Expression and Protein in Caco-2 Cells

Journal of Clinical Lipidology, 2012
Matthew K. Ito, Shobana Ganesan, Grace I. Judd, Atanaz Zargar, Ali J. Olyaie   +4 more
openalex   +2 more sources

S1236 Inhibition of Ceramide Decreased the Expression of ATP-Binding Cassette Transporter G5 mRNA in the Animal Model of Cholesterol Gallstone

Gastroenterology, 2010
Hyo Jung Kim, Jae Seon Kim, Han Chun, Su Rin Shin, Jin‐Bae Kim, Il Hyun Baek, Myung Seok Lee, Seikwan Oh, Youn-Sun Lee, Hwan‐Soo Yoo   +9 more
openalex   +2 more sources