Results 101 to 110 of about 30,215 (258)

Citrate Promotes Nitric Oxide Production during Human Sperm Capacitation

Antioxidants
Sperm capacitation is a complex process essential for the spermatozoon to recognize and fertilize the oocyte. For capacitation to occur, human spermatozoa require low levels of reactive oxygen species (ROS), increased protein tyrosine phosphorylation ...
Diego Loggia, Cristian O’Flaherty
doaj   +1 more source

Sulforaphane, a cancer chemopreventive agent, induces pathways associated with membrane biosynthesis in response to tissue damage by aflatoxin B1 [PDF]

, 2014
Aflatoxin B[subscript 1] (AFB[subscript 1]) is one of the major risk factors for liver cancer globally. A recent study showed that sulforaphane (SF), a potent inducer of phase II enzymes that occurs naturally in widely consumed vegetables, effectively ...
Croy, Robert G, Essigmann, John M, Fiala, Jeanette LouiseAllen, Groopman, John D., Navasumrit, Panida, Ruchirawat, Mathuros, Techapiesancharoenkij, Nirachara, Wogan, Gerald N   +7 more
core   +1 more source

Phosphate Resupply Differentially Impacts the Shoot and Root Proteomes of Arabidopsis thaliana Seedlings

Plant, Cell &Environment, EarlyView.
ABSTRACT Phosphate (Pi) is an essential macronutrient for plant development that is often limited in soil. Plants have evolved dynamic biochemical, physiological and morphological adaptations to cope with Pi deficiency, known as the Pi starvation response (PSR).
Milena A. Smith, Lauren E. Grubb, Kirsten H. Benidickson, Devang Mehta, William C. Plaxton, R. Glen Uhrig   +5 more
wiley   +1 more source

Comparative Metabolites and Citrate-Degrading Enzymes Activities in Citrus Fruits Reveal the Role of Balance between ACL and Cyt-ACO in Metabolite Conversions

Plants, 2020
Citric acid metabolism is considered to be the central cellular process of metabolite conversions. ATP-citrate lyase (ACL) and cytosolic aconitase (cyt-ACO) are the two citrate-degrading enzymes that decide the carbon flux towards different metabolite ...
Lingxia Guo, Yongzhong Liu, Lijuan Luo, Syed Bilal Hussain, Yingxin Bai, Shariq Mahmood Alam   +5 more
doaj   +1 more source

Modeling cancer metabolism on a genome scale [PDF]

, 2015
Cancer cells have fundamentally altered cellular metabolism that is associated with their tumorigenicity and malignancy. In addition to the widely studied Warburg effect, several new key metabolic alterations in cancer have been established over the last
Barbara Chaneton, Eyal Gottlieb, Eytan Ruppin, Keren Yizhak, Kiuru M, Li L, Lobo C, Som P, Vazquez‐Martin A   +8 more
core   +1 more source

ATP-citrate lyase is essential for macrophage inflammatory response

Biochemical and Biophysical Research Communications, 2013
Growing evidence suggests that energy metabolism and inflammation are closely linked and that cross-talk between these processes is fundamental to the pathogenesis of many human diseases. However, the molecular mechanisms underlying these observations are still poorly understood. Here we describe the key role of ATP-citrate lyase (ACLY) in inflammation.
Infantino V., Iacobazzi V., Palmieri F., Menga A.   +3 more
openaire   +4 more sources

Longitudinal metabolomics study of phosphate‐adenine‐guanosine‐glucose‐saline‐mannitol stored red blood cells

Transfusion, EarlyView.
Abstract Background The storage of red blood cells (RBCs) is essential for transfusion but leads to storage lesions that compromise RBC quality and increase the risk of transfusion‐related adverse effects, including allergic transfusion reactions (ATRs). Understanding storage‐induced metabolic change is crucial for enhancing transfusion safety.
Gürkan Bal, Maia Dzamashvili, Zhuoran Li, Magda Babina, Nidal Toman, Abdulgabar Salama   +5 more
wiley   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

Differential metabolism of Mycoplasma species as revealed by their genomes [PDF]

, 2007
The annotation and comparative analyses of the genomes of Mycoplasma synoviae and Mycoplasma hyopneumonie, as well as of other Mollicutes (a group of bacteria devoid of a rigid cell wall), has set the grounds for a global understanding of their ...
Altschul SF, Andrea Q. Maranhão, Angata T, Begley TP, Bradbury JM, Chaturvedi V, Chaturvedi V, Cho MK, Doman-Pytka M, Eze MO, Fabricio B.M. Arraes, Fábio O. Pedrosa, Glass JI, Hoffmann GE, Levine RL, Marcelo M. Brígido, Maria José A. de Carvalho, Maria Sueli S. Felipe, Meinnel T, Morowitz HJ, Morris VK, Mushegian AR, Oshima K, Pei D, Peterson SN, Pitkänen JP, Razin S, Razin S, Rittmann D, San Mateo LR, Tauber AI, Varki A, Vasconcelos AT, Vestweber D, Zimmer C   +34 more
core   +2 more sources

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source