Results 131 to 140 of about 321,932 (261)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Increased ATP Release and Higher Impact of Adenosine A_2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson's Disease. [PDF]

Mol Neurobiol, 2023
Gonçalves FQ, Matheus FC, Silva HB, Real JI, Rial D, Rodrigues RJ, Oses JP, Silva AC, Gonçalves N, Prediger RD, Tomé ÂR, Cunha RA.   +11 more
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress. [PDF]

ACS Chem Neurosci, 2023
Dias L, Pochmann D, Lemos C, Silva HB, Real JI, Gonçalves FQ, Rial D, Gonçalves N, Simões AP, Ferreira SG, Agostinho P, Cunha RA, Tomé AR.   +12 more
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Cellular signaling pathway of Shiga toxin-induced ATP release. [PDF]

Front Cell Infect Microbiol
Johansson K, Arvidsson I, Wendler M, Kristoffersson AC, Karpman D.   +4 more
europepmc   +1 more source

Mechanisms of ATP release in pain: role of pannexin and connexin channels. [PDF]

Purinergic Signal, 2021
Muñoz MF, Griffith TN, Contreras JE.
europepmc   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Activation of TRPV3 channels in bladder cancer cells stimulates ATP release. [PDF]

Mol Pharmacol
Janenz J, Leipe A, Urban N, Schaefer M, Hill K.   +4 more
europepmc   +1 more source

Propidium uptake and ATP release in A549 cells share similar transport mechanisms. [PDF]

Biophys J, 2022
Boudreault F, Tan JJ, Grygorczyk R.
europepmc   +1 more source