Results 121 to 130 of about 837,065 (393)

ATP synthase: a tentative structural model [PDF]

FEBS Letters, 1997
Adenosine triphosphate (ATP) synthase produces ATP from ADP and inorganic phosphate at the expense of proton‐ or sodium‐motive force across the respective coupling membrane in Archaea, Bacteria and Eucarya. Cation flow through the intrinsic membrane portion of this enzyme (FO, subunits ab 2 c 9–12) and substrate turnover in the headpiece (F1, subunits ...
Siegfried Engelbrecht, Wolfgang Junge
openaire   +3 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Regulatory assembly of the vacuolar proton pump VOV1-ATPase in yeast cells by FLIM-FRET

, 2010
We investigate the reversible disassembly of VOV1-ATPase in life yeast cells by time resolved confocal FRET imaging. VOV1-ATPase in the vacuolar membrane pumps protons from the cytosol into the vacuole. VOV1-ATPase is a rotary biological nanomotor driven
Batisse, Claire, Boersch, Michael, Boettcher, Bettina, Ernst, Stefan, Zarrabi, Nawid   +4 more
core   +1 more source

Purified F-ATP synthase forms a Ca2+-dependent high-conductance channel matching the mitochondrial permeability transition pore

Nature Communications, 2019
The molecular identity of the mitochondrial megachannel (MMC)/permeability transition pore (PTP), a key effector of cell death, remains controversial. By combining highly purified, fully active bovine F-ATP synthase with preformed liposomes we show that ...
A. Urbani, V. Giorgio, Andrea Carrer, C. Franchin, G. Arrigoni, C. Jiko, K. Abe, Shintaro Maeda, K. Shinzawa-Itoh, J. F. Bogers, D. G. McMillan, C. Gerle, I. Szabó, P. Bernardi   +13 more
semanticscholar   +1 more source

Discovery of a novel Mycobacterial F-ATP synthase inhibitor and its potency in combination with diarylquinolines.

Angewandte Chemie, 2020
The F 1 F O -ATP synthase is required for growth and viability of Mycobacterium tuberculosis . Bedaquiline validated this target clinically. We showed recently that a mycobacterium-specific loop of the enzyme's rotary γ subunit plays a role in coupling ...
Adam Hotra, P. Ragunathan, P. Ng, Pattarakiat Seankongsuk, A. Harikishore, J. Sarathy, W. Saw, Umayal Lakshmanan, Patcharaporn Sae-Lao, N. Kalia, Joon Shin, R. Kalyanasundaram, S. Anbarasu, Krupakar Parthasarathy, C. Pradeep, Harshyaa Makhija, P. Dröge, Anders Poulsen, J. Tan, Kevin Pethe, T. Dick, R. Bates, G. Grüber   +22 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

Overexpression of mitochondrial if1 prevents metastatic disease of colorectal cancer by enhancing anoikis and tumor infiltration of NK cells [PDF]

, 2019
Increasing evidences show that the ATPase Inhibitory Factor 1 (IF1), the physiological inhibitor of the ATP synthase, is overexpressed in a large number of carcinomas contributing to metabolic reprogramming and cancer progression. Herein, we show that in
Cuezva, José M., García-Aguilar, Ana, González-García, Sara, González-Llorente, Lucía, Nuevo-Tapioles, Cristina, Santacatterina, Fulvio, Tirpakova, Zuzana, Toribio, María Luisa   +7 more
core   +1 more source

Three-Dimensional Analysis of Mitochondrial Crista Ultrastructure in a Patient with Leigh Syndrome by In Situ Cryoelectron Tomography

iScience, 2018
Summary: Mitochondrial diseases produce profound neurological dysfunction via mutations affecting mitochondrial energy production, including the relatively common Leigh syndrome (LS).
Stephanie E. Siegmund, Robert Grassucci, Stephen D. Carter, Emanuele Barca, Zachary J. Farino, Martí Juanola-Falgarona, Peijun Zhang, Kurenai Tanji, Michio Hirano, Eric A. Schon, Joachim Frank, Zachary Freyberg   +11 more
doaj   +1 more source

A mitochondrial megachannel resides in monomeric F1FO ATP synthase

Nature Communications, 2019
Purified mitochondrial ATP synthase has been shown to form Ca2+-activated, large conductance channel activity similar to that of mitochondrial megachannel (MMC) or mitochondrial permeability transition pore (mPTP) but the oligomeric state required for ...
N. Mnatsakanyan, M. Llaguno, Youshan Yang, Yangyang Yan, J. Weber, F. Sigworth, E. Jonas   +6 more
semanticscholar   +1 more source