Results 291 to 300 of about 837,065 (393)

Engineered Fusion Enzyme‐Mediated Non‐Consecutive Cyclization‐Glycosylation Enables Heterologous Synthesis of Antifungal Enfumafungin

Advanced Science, EarlyView.
The artificial biosynthetic pathway potentially involved in biosynthesis of enfumafungin is first reconstructed in an optimized Aspergillus oryzae chassis with the increased site‐specific integration efficiency and shortened time for marker recycling, which requires an artificial fusion enzyme EfuA(TC)FsoA(GT).
Yaohui Gao, Jianming Lv, Yue Zhong, Zhiqin Cao, Rui Luo, Yue Qi, Gaoqian Wang, Shaoyang Li, Guodong Chen, Dan Hu, Hao Gao, Xinsheng Yao   +11 more
wiley   +1 more source

Purified inositol hexakisphosphate kinase is an ATP synthase: diphosphoinositol pentakisphosphate as a high-energy phosphate donor.

, 1996
Susan M. Voglmaier, Michael E. Bembenek, Adam Kaplin, György Dormán, John D. Olszewski, Glenn D. Prestwich, Solomon H. Snyder   +6 more
openalex   +1 more source

Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms

Advanced Science, EarlyView.
In KRAS‐mutant tumors, KRAS transcriptionally upregulates COA4 via the PI3K/AKT/E2F1 axis, promoting metastasis. Mechanistically, COA4 enhances tumor cell migration through dual pathways: within mitochondria, it boosts oxidative phosphorylation; in the cytoplasm, it binds and activates CDC42 to stimulate pseudopodia formation.
Xingzhao Ji, Weiying Zhang, Fuyuan Xue, Jiazhen Zeng, Qinghua Zhao, Xiaoming Sun, Jian Sun, Heng Zhou, Quanlin Xu, Guoyuan Ma, Shengnan Sun, Ying Wang, Qian Mu, Yi Liu, Qiang Wan   +14 more
wiley   +1 more source

Sudapyridine (WX-081) inhibits <i>Mycobacterium tuberculosis</i> by targeting ATP synthase and upregulating host innate immunity. [PDF]

mSphere
Li X, Luo X, Wang B, Fu L, Chen X, Lu Y.
europepmc   +1 more source

Structure of the subunit c oligomer in the F ₁ F _o ATP synthase: Model derived from solution structure of the monomer and cross-linking in the native enzyme

, 1999
Oleg Y. Dmitriev, Phil Jones, Robert Fillingame   +2 more
openalex   +1 more source

Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng, Min Hong, Zhaocai Zhang, Ximing Ye, Jianan Zhou, Wentao Wu, Jiabing Rong, Yinchuan Xu   +7 more
wiley   +1 more source

Effect of Chloroplast ATP Synthase on Reactive Oxygen Species Metabolism in Cotton. [PDF]

Int J Mol Sci
Zhang L, Jing P, Geng B, Zhang J, Shi J, Liang D, Yang Y, Qu Y, Huang J.   +8 more
europepmc   +1 more source

A Refined Adaptive Laboratory Evolution Strategy With Biosensor‐Assisted Selection Resolves the Tolerance–Efficiency Trade‐Off in Toxic Chemical Biosynthesis

Advanced Science, EarlyView.
This study presents a refined adaptive laboratory evolution (ALE) strategy to resolve the trade‐off between tolerance and biosynthetic efficiency in toxic chemical production. Combining in vivo mutagenesis, microdroplet‐based evolution, and biosensor‐assisted selection, this strategy rapidly yields robust “win‐win” phenotypes.
Yufei Zhang, Junhua Yun, Guoyan Zhang, Hossain M. Zabed, Yuehui Tian, Xinrui Tang, Jia Li, Xianghui Qi   +7 more
wiley   +1 more source

Single-cell mitochondrial morphomics reveals cellular heterogeneity and predicts complex I, III, and ATP synthase Inhibition responses. [PDF]

Sci Rep
Sutharsan R, Biaut Hontaas M, Li Y, Xiong H, Preckel H, Sue CM, Wali G.   +6 more
europepmc   +1 more source

Assembly of the membrane domain of ATP synthase in human mitochondria

Proceedings of the National Academy of Sciences of the United States of America, 2018
Jiuya He, Holly C Ford, J. Carroll, Corsten Douglas, E. Gonzales, Shujing Ding, I. Fearnley, J. Walker   +7 more
semanticscholar   +1 more source