Results 361 to 370 of about 837,065 (393)
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The regulation of catalysis in ATP synthase
Current Opinion in Structural Biology, 1994ATP synthase is regulated so as to prevent futile hydrolysis of ATP when the transmembrane proton electrochemical gradient, delta mu H+, falls. Mitochondria and chloroplasts have different mechanisms for inhibition of ATP synthase: by binding an inhibitor protein, and by stabilization of the ADP-inhibited state by making an intramolecular disulphide ...
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The Catalytic Transition State in ATP Synthase
Journal of Bioenergetics and Biomembranes, 2000The catalytic transition state of ATP synthase has been characterized and modeled by combined use of (1) Mg-ADP-fluoroaluminate, Mg-ADP-fluoroscandium, and corresponding Mg-IDP-fluorometals as transition-state analogs; (2) fluorescence signals of beta-Trp331 and beta-Trp148 as optical probes to assess formation of the transition state; (3) mutations of
Alan E. Senior +2 more
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ATP synthase: structure-function relationships
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1992Recent work has focused on obtaining a better understanding of the three-dimensional structural relationships between the alpha and beta subunits of the F1 moiety and the location of nucleotide binding domains within these subunits. Four types of approach are currently being pursued: X-ray crystallographic, chemical, molecular biological and ...
Peter L. Pedersen +5 more
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2004
F1-F= ATP synthases are large protein complexes located in the inner mitochondrial membrane,in the chloroplast thylakoid membrane and in the bacterial plasma membrane. They are the major ATP suppliers of most cells. Structural, biochemical and molecular biological studies have contributed to the knowledge of the architecture and catalytic mechanism of ...
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F1-F= ATP synthases are large protein complexes located in the inner mitochondrial membrane,in the chloroplast thylakoid membrane and in the bacterial plasma membrane. They are the major ATP suppliers of most cells. Structural, biochemical and molecular biological studies have contributed to the knowledge of the architecture and catalytic mechanism of ...
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Mechanism of ATP Synthesis by Mitochondrial ATP Synthase
1999Adenosine triphosphate (ATP) is the major energy carrier in living cells, facilitating the flow of chemical potential energy from a variety of catabolic reactions to energy-requiring cellular processes (Lehninger, 1975). Oxidative phosphorylation is the major source of cellular ATP, and the enzymes and other molecules involved in the process are ...
Harvey S. Penefsky, Abdul-Kader Souid
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Cryo-EM structure of the entire mammalian F-type ATP synthase
Nature Structural & Molecular Biology, 2020G. Pinke, Long Zhou, L. Sazanov
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Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline
Nature, 2020Hui Guo +5 more
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Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587.
NatureYuying Zhang +18 more
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