Results 61 to 70 of about 329,086 (345)
Is there NO treatment for severe sepsis? [PDF]
, 2008 Sepsis is a systemic inflammatory response syndrome in the presence of suspected or proven infection, and it may progress to or encompass organ failure (severe sepsis) and hypotension (septic shock).
Bredan, Amin, Cauwels, Anje
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The Journal of Clinical Investigation, 2022 In hypertrophied and failing hearts, fuel metabolism is reprogrammed to increase glucose metabolism, especially glycolysis. This metabolic shift favors biosynthetic function at the expense of ATP production.
Bo Zhou +14 more
doaj +1 more source
Quick guide: ATP synthase [PDF]
Current Biology, 2001 Also known as… F1Fo ATP synthase, F1Fo ATPase, F-type ATPase. F1 denotes the soluble catalytic headgroup where ATP synthesis and hydrolysis occur, and Fo is the ion-translocating membrane domain (see Fig. 1Fig. 1).Fig. 1An illustration of the E. coli F1Fo. F1 is made up of five different subunits, with a stoichiometry α3β3γδe, and the composition of Fo
Arechaga, Ignacio, Jones, Phil C.
openaire +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
, 2012 Thermophilic enzymes can operate at higher temperatures but show reduced activities at room temperature. They are in general more stable during preparation and, accordingly, are considered to be more rigid in structure.
Boersch, Michael +7 more
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In vivo inhibition of the mitochondrial H+-ATP synthase in neurons promotes metabolic preconditioning [PDF]
, 2014 A key transducer in energy conservation and signaling cell death is the mitochondrial H+-ATP synthase. The expression of the ATPase inhibitory factor 1 (IF1) is a strategy used by cancer cells to inhibit the activity of the H+-ATP synthase to generate a ...
Cuezva, José M. +7 more
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Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer’s disease
Nature Communications, 2016 F1FO ATP synthase is a critical enzyme for the maintenance of mitochondrial function. Here the authors demonstrate that loss of the F1FO-ATP synthase subunit OSCP and the interaction of OSCP with Aβ peptide in Alzheimer’s disease patients and mouse ...
Simon J. Beck +10 more
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Highly divergent mitochondrial ATP synthase complexes in Tetrahymena thermophila. [PDF]
PLoS Biology, 2010 The F-type ATP synthase complex is a rotary nano-motor driven by proton motive force to synthesize ATP. Its F(1) sector catalyzes ATP synthesis, whereas the F(o) sector conducts the protons and provides a stator for the rotary action of the complex ...
Praveen Balabaskaran Nina +6 more
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Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase [PDF]
, 2016 Misfolded α-synuclein is a key factor in the pathogenesis of Parkinson's disease (PD). However, knowledge about a physiological role for the native, unfolded α-synuclein is limited.
Abramov, A +5 more
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