Results 61 to 70 of about 837,065 (393)

GaMF1.39’s antibiotic efficacy and its enhanced antitubercular activity in combination with clofazimine, Telacebec, ND-011992, or TBAJ-876

Microbiology Spectrum, 2023
The Mycobacterium tuberculosis (Mtb) F-ATP synthase generates most of the biological energy currency ATP. Previously, we identified the mycobacterium-specific loop of the F-ATP synthase subunit γ as a new anti-tuberculosis target and discovered the novel
Priya Ragunathan, Pearly Shuyi Ng, Samsher Singh, Wee Han Poh, Dennis Litty, Nitin Pal Kalia, Simon Larsson, Amaravadhi Harikishore, Scott A. Rice, Philip W. Ingham, Volker Müller, Garrett Moraski, Marvin J. Miller, Thomas Dick, Kevin Pethe, Gerhard Grüber   +15 more
doaj   +1 more source

Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons [PDF]

, 2017
Mutations in the gene encoding valosin-containing protein (VCP) lead to multisystem proteinopathies including frontotemporal dementia. We have previously shown that patient-derived VCP mutant fibroblasts exhibit lower mitochondrial membrane potential ...
Abramov, Andrey Y. Abramov, Angelova, Bartolome, Bobba, Brand, Brown, Charles Arber, Ding, Edri, Elisavet Preza, Eva Carro, Fernando Bartolome, Ganote, Henry Houlden, Imamura, Johnson, Kokoszka, Krauss, Ludtmann, Macarena de Vicente, Marthe H.R. Ludtmann, Meyer, Muqit, Nalbandian, Nalbandian, Nalbandian, Okita, Papkovskaia, Plun-Favreau, Schirris, Selina Wray, Shi, Shi, Sonia Gandhi, Sposito, Vallier, Vieira, Weihl, Weinbach, Weydt, Wray, Yin, Zhivotovsky   +43 more
core   +2 more sources

Novel insights into the Thaumarchaeota in the deepest oceans: their metabolism and potential adaptation mechanisms [PDF]

, 2020
Background: Marine Group I (MGI) Thaumarchaeota, which play key roles in the global biogeochemical cycling of nitrogen and carbon (ammonia oxidizers), thrive in the aphotic deep sea with massive populations.
Lehtovirta-Morley, Laura, Lin, Heyu, Liu, Jiwen, Song, Delei, Tian, Jiwei, Todd, Jonathan, Zhang, Xiao-Hua, Zheng, Yanfen, Zhong, Haohui   +8 more
core   +2 more sources

Kinetic coupling of the respiratory chain with ATP synthase, but not proton gradients, drives ATP production in cristae membranes

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Mitochondrial energy conversion occurs in the folded invaginations of the inner mitochondrial membrane termed cristae. Electron microscopy identified these structures 75 y ago and inspired work regarding the mechanisms of mitochondrial ...
A. Tóth, Axel Meyrat, S. Stoldt, R. Santiago, Dirk Wenzel, S. Jakobs, Christoph von Ballmoos, M. Ott   +7 more
semanticscholar   +1 more source

Visualizing mitochondrial FoF1-ATP synthase as the target of the immunomodulatory drug Bz-423

, 2018
Targeting the mitochondrial enzyme FoF1-ATP synthase and modulating its catalytic activities with small molecules is a promising new approach for treatment of autoimmune diseases. The immuno-modulatory compound Bz-423 is such a drug that binds to subunit
Börsch, Michael, Glick, Gary D., Starke, Ilka   +2 more
core   +1 more source

Structure, Regulation, and Significance of Cyanobacterial and Chloroplast Adenosine Triphosphate Synthase in the Adaptability of Oxygenic Photosynthetic Organisms

Microorganisms
In cyanobacteria and chloroplasts (in algae and plants), ATP synthase plays a pivotal role as a photosynthetic membrane complex responsible for producing ATP from adenosine diphosphate and inorganic phosphate, utilizing a proton motive force gradient ...
Siyan Yi, Xin Guo, Wenjing Lou, Shaoming Mao, Guodong Luan, Xuefeng Lu   +5 more
doaj   +1 more source

Identification of cryptic subunits from an apicomplexan ATP synthase

eLife, 2018
The mitochondrial ATP synthase is a macromolecular motor that uses the proton gradient to generate ATP. Proper ATP synthase function requires a stator linking the catalytic and rotary portions of the complex.
Diego Huet, Esther Rajendran, Giel G van Dooren, Sebastian Lourido   +3 more
doaj   +1 more source

Spatial and temporal dynamics of ATP synthase from mitochondria toward the cell surface

Communications Biology, 2023
Ectopic ATP synthase complex (eATP synthase), located on cancer cell surface, has been reported to possess catalytic activity that facilitates the generation of ATP in the extracellular environment to establish a suitable microenvironment and to be a ...
Yi-Wen Chang, T. Tony Yang, Min-Chun Chen, Y-geh Liaw, Chieh-Fan Yin, Xiu-Qi Lin-Yan, Ting-Yu Huang, Jen-Tzu Hou, Yi-Hsuan Hung, Chia-Lang Hsu, Hsuan-Cheng Huang, Hsueh-Fen Juan   +11 more
doaj   +1 more source

A Blue Native-PAGE analysis of membrane protein complexes in Clostridium thermocellum [PDF]

, 2011
Background Clostridium thermocellum is a Gram-positive thermophilic anaerobic bacterium with the unusual capacity to convert cellulosic biomass into ethanol and hydrogen. Identification and characterization of protein complexes in C.
Fan, Keqiang, Luo, Yuanming, Peng, Yanfeng, Xu, Xinping, Yang, Kequian, Yu, Tingting, Zhao, Youbao   +6 more
core   +3 more sources

The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]

, 2013
Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Alex Dyson, Audibert G, Berne RM, Blitzer ML, Boutilier RG, Brown IP, Devlin C, Furukawa K, Hall JE, Heyes MP, Jekabsone A, Lehninger A, Leone AM, Louis CA, Martin Feelisch, Mervyn Singer, Michele Umbrello, Modin A, Munk VC, Pohl U, Rengasamy A, Rengasamy A, Vallance P, Whorton AR   +23 more
core   +1 more source