Results 61 to 70 of about 309,313 (234)
Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer
Cancer Medicine, 2018 Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H+‐transporter that pumps protons across intracellular and plasma membranes. It consists of a large multi‐subunit protein complex and influences a wide range of cellular processes.
Bradleigh Whitton +3 more
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Control of calcium homeostasis in Schistosoma mansoni
Memorias do Instituto Oswaldo Cruz, 2001 Calcium signalling is fundamental for muscular contractility of Schistosoma mansoni. We have previously described the presence of transport ATPases (Na+,K+-ATPase and (Ca2+-Mg2+)-ATPase) and calcium channels (ryanodine receptors - RyR) involved in ...
F Noël +3 more
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Neural Regeneration ResearchNa+/K+-ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three Na+ out of and two K+ into cells.
Songqiang Huang +3 more
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V-ATPase Dysfunction in the Brain: Genetic Insights and Therapeutic Opportunities
CellsVacuolar-type ATPase (v-ATPase) is a multimeric protein complex that regulates H+ transport across membranes and intra-cellular organelle acidification. Catabolic processes, such as endocytic degradation and autophagy, strictly rely on v-ATPase-dependent
Antonio Falace +5 more
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The curious case of vacuolar ATPase: regulation of signaling pathways
Molecular Cancer, 2018 The Vacuolar ATPase (V-ATPase) is a proton pump responsible for controlling the intracellular and extracellular pH of cells. The structure of V-ATPase has been highly conserved among all eukaryotic cells and is involved in diverse functions across ...
Sahithi Pamarthy +3 more
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F-actin reorganization by V-ATPase inhibition in prostate cancer
Biology Open, 2017 The vacuolar ATPase (V-ATPase) proton pump sustains cellular pH homeostasis, and its inhibition triggers numerous stress responses. However, the cellular mechanisms involved remain largely elusive in cancer cells.
Yamhilette Licon-Munoz +3 more
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Histochemistry of ATPases. [PDF]
Journal of Histochemistry & Cytochemistry, 1990 D G Baskin, William L. Stahl
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Sodium or potassium efflux ATPase
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2010 The K(+) and Na(+) concentrations in living cells are strictly regulated at almost constant concentrations, high for K(+) and low for Na(+). Because these concentrations correspond to influx-efflux steady states, K(+) and Na(+) effluxes and the transporters involved play a central role in the physiology of cells, especially in environments with high Na(
Begoña Benito +1 more
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Asian Pacific Journal of Tropical Biomedicine, 2019 Objective: To assess the protective effect of galangin on membrane bound enzymes in rats with streptozotocin-induced diabetes. Methods: A single low dose of streptozotocin was injected to adult male albino rats to induce hyperglycemia. Galangin (8 mg/kg)
Amal A Aloud +4 more
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Rotational catalysis in proton pumping ATPases: From E. coli F-ATPase to mammalian V-ATPase
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2012 We focus on the rotational catalysis of Escherichia coli F-ATPase (ATP synthase, F(O)F(1)). Using a probe with low viscous drag, we found stochastic fluctuation of the rotation rates, a flat energy pathway, and contribution of an inhibited state to the overall behavior of the enzyme. Mutational analyses revealed the importance of the interactions among
Futai, Masamitsu +4 more
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