Results 221 to 230 of about 98,797 (266)
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Nature Reviews Cancer, 2018
The chemical treatment of cancer started with the realization that DNA damaging agents such as mustard gas present notable antitumoural properties. Consequently, early drug development focused on genotoxic chemicals, some of which are still widely used in the clinic.
Lecona E, Fernandez-Capetillo O
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The chemical treatment of cancer started with the realization that DNA damaging agents such as mustard gas present notable antitumoural properties. Consequently, early drug development focused on genotoxic chemicals, some of which are still widely used in the clinic.
Lecona E, Fernandez-Capetillo O
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SPIE Proceedings, 2008
The purpose of the Automatic Target Recognition (ATR) Center is to develop an environment conducive to producing theoretical and practical advances in the field of ATR. This will be accomplished by fostering intellectual growth of ATR practitioners at all levels.
Gregory Arnold +4 more
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The purpose of the Automatic Target Recognition (ATR) Center is to develop an environment conducive to producing theoretical and practical advances in the field of ATR. This will be accomplished by fostering intellectual growth of ATR practitioners at all levels.
Gregory Arnold +4 more
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Targeting ATR in Cancer Medicine
2023As a key component of the DNA Damage Response, the Ataxia telangiectasia and Rad3-related (ATR) protein is a promising druggable target that is currently widely evaluated in phase I-II-III clinical trials as monotherapy and in combinations with other rational antitumor agents, including immunotherapy, DNA repair inhibitors, chemo- and radiotherapy ...
Carolina, Salguero +4 more
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Diachronica, 2006
Jumjum, a Western Nilotic language, has an eight-vowel system divided into two sets by the feature [ATR] (Advanced Tongue Root), which is the basis of vowel harmony. A comparison with other Western Nilotic languages shows that (i) this vowel system goes back to a ten-vowel system in Proto-Western Nilotic (PWN), (ii) PWN high [−ATR] vowels have become ...
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Jumjum, a Western Nilotic language, has an eight-vowel system divided into two sets by the feature [ATR] (Advanced Tongue Root), which is the basis of vowel harmony. A comparison with other Western Nilotic languages shows that (i) this vowel system goes back to a ten-vowel system in Proto-Western Nilotic (PWN), (ii) PWN high [−ATR] vowels have become ...
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ATR Inhibitors and Paclitaxel in Melanoma
Clinical Cancer Research, 2021Abstract A phase I study defined a tolerable combination of the ATR inhibitor ceralasertib with paclitaxel and responses were seen in patients with melanoma who had progressed on an immune checkpoint inhibitor. This combination warrants further exploration to determine the extent and molecular determinants of clinical activity.
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Targeting ATR in patients with cancer
Nature Reviews Clinical OncologyPharmacological inhibition of the ataxia telangiectasia and Rad3-related protein serine/threonine kinase (ATR; also known as FRAP-related protein (FRP1)) has emerged as a promising strategy for cancer treatment that exploits synthetic lethal interactions with proteins involved in DNA damage repair, overcomes resistance to other therapies and enhances ...
Natalie Yl Ngoi +2 more
exaly +3 more sources
ATR dependent activation of Chk2
Journal of Cellular Physiology, 2006AbstractATM and ATR are essential regulators of DNA damage checkpoints in mammalian cells through their respective effectors, Chk2 and Chk1. Cross regulation of the ATM‐Chk2 and ATR‐Chk1 pathways is very limited, although ATM and ATR show overlapping function in a partnership and time‐dependent manner.
Wang, XQ +3 more
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Forensic Science International, 2015
In this article, five hundred and thirteen cocaine seizures of the State of Rio Grande do Sul (Brazil) were analyzed by Fourier transform infrared spectroscopy (FT-IR) in the fingerprint region (1800-650 cm(-1)) to profiling and evaluate the pharmaceutical products used as adulterants.
M C A, Marcelo +3 more
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In this article, five hundred and thirteen cocaine seizures of the State of Rio Grande do Sul (Brazil) were analyzed by Fourier transform infrared spectroscopy (FT-IR) in the fingerprint region (1800-650 cm(-1)) to profiling and evaluate the pharmaceutical products used as adulterants.
M C A, Marcelo +3 more
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How ATR turns on: TopBP1 goes on ATRIP with ATR.
Genes & development, 2008In this issue of Genes & Development, Mordes and colleagues (pp. 1478-1489) reveal intriguing mechanistic insights into activation of the ATR (ATM and Rad3-related) kinase critical for DNA damage resistance. They identify conserved regulatory domains within ATR and its binding partner ATRIP (ATR-interacting protein), which are contacted by the ATR ...
Anna E, Burrows, Stephen J, Elledge
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ATR Harmony in African Languages
Language and Linguistics Compass, 2008Abstract A widespread phonological pattern in African languages of the Niger‐Congo and Nilo‐Saharan families is a type of vowel harmony or assimilation based on a phonological feature [ATR], or advanced tongue root. This article introduces the general behavior of African ATR harmony systems, briefly describes their geographic and ...
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