The ChIP-seq-defined networks of Bcl-3 gene binding support its required role in skeletal muscle atrophy [PDF]
, 2012 NF-kappaB transcriptional activation is required for skeletal muscle disuse atrophy. We are continuing to study how the activation of NF-kB regulates the genes that encode the protein products that cause atrophy. Using ChIP-sequencing we found that Bcl-3,
Jackman, Robert W. +2 more
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Phenomenological model of diffuse global and regional atrophy using finite-element methods [PDF]
, 2006 The main goal of this work is the generation of ground-truth data for the validation of atrophy measurement techniques, commonly used in the study of neurodegenerative diseases such as dementia.
Camara, O. +9 more
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Association between cognitive performance and cortical glucose metabolism in patients with mild Alzheimer's disease [PDF]
, 2005 Background: Neuronal and synaptic function in Alzheimer's disease (AD) is measured in vivo by glucose metabolism using positron emission tomography (PET). Objective: We hypothesized that neuronal activation as measured by PET is a more sensitive index of
A. Drzezga +27 more
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Risk Factors for Gastric Tumorigenesis in Underlying Gastric Mucosal Atrophy
Gut and Liver, 2017 Background/AimsAtrophic gastritis is considered a premalignant lesion. We aimed to evaluate the risk factors for gastric tumorigenesis in underlying mucosal atrophy.Methods : A total of 10,185 subjects who underwent upper gastrointestinal endoscopy ...
Ji Hyun Song +4 more
doaj +1 more source
Increased prevalence of precancerous changes in relatives of gastric cancer patients: critical role of H. pylori [PDF]
, 2000 Background & Aims:Helicobacter pylori is believed to predispose to gastric cancer by inducing gastric atrophy and hypochlorhydria. First-degree relatives of patients with gastric cancer have an increased risk of developing gastric cancer.
El–Nujumi, Adil +8 more
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Arquivos de Neuro-Psiquiatria, 2007 Hypomyelination with atrophy of the basal ganglia and cerebellum (H-ABC) is a rare disease that has been recently described. It must be remembered as a possible etiology of leukoencephalopathies in children.
André Palma da Cunha Matta +1 more
doaj +1 more source
Obesity and Gray Matter Volume Assessed by Neuroimaging: A Systematic Review
Brain Sciences, 2021 Obesity has become a major public and individual health problem due to its high worldwide prevalence and its relation with comorbid conditions. According to previous studies, obesity is related to an increased risk of cognitive impairment and dementia ...
Marina Fernández-Andújar +2 more
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Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1990 ABSTRACT:Weakness of distal muscles of one upper limb which progresses over 1 year and then appears to arrest (“monomelic amyotrophy”) has been reported mainly in Japan and India. We report 5 cases of a similar syndrome occurring in Canada. In our cases the wasting affected the forearm muscles of one upper limb (sparing brachioradialis and extensor ...
J, Oryema, P, Ashby, S, Spiegel
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Current evidence for treatment with nusinersen for spinal muscular atrophy : a systematic review [PDF]
, 2019 Recent discovery of nusinersen, an antisense oligonucleotide drug, has provided encouragement for improving treatment of spinal muscular atrophy. No therapeutic options currently exist for this autosomal recessive motor neuron disorder.
Meylemans, Antoon, De Bleecker, Jan
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Kufor-Rakeb syndrome, pallido-pyramidal degeneration with supranuclear upgaze paresis and dementia, maps to 1p36 [PDF]
, 2001 Kufor-Rakeb syndrome is an autosomal recessive nigro-striatal-pallidal-pyramidal neurodegeneration. The onset is in the teenage years with clinical features of Parkinson’s disease plus spasticity, supranuclear upgaze paresis, and dementia.
Al-Din, A. +7 more
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