Results 11 to 20 of about 1,027,501 (383)

The ChIP-seq-defined networks of Bcl-3 gene binding support its required role in skeletal muscle atrophy [PDF]

, 2012
NF-kappaB transcriptional activation is required for skeletal muscle disuse atrophy. We are continuing to study how the activation of NF-kB regulates the genes that encode the protein products that cause atrophy. Using ChIP-sequencing we found that Bcl-3,
Jackman, Robert W., Kandarian, Susan C., Wu, Chia-Ling   +2 more
core   +10 more sources

Nusinersen versus Sham Control in Later‐Onset Spinal Muscular Atrophy [PDF]

New England Journal of Medicine, 2018
E. Mercuri, B. Darras, C. Chiriboga, J. Day, C. Campbell, A. Connolly, S. Iannaccone, J. Kirschner, N. Kuntz, Kayoko Saito, P. Shieh, M. Tulinius, E. Mazzone, J. Montes, K. Bishop, Qingqing Yang, R. Foster, S. Gheuens, F. Bennett, W. Farwell, E. Schneider, D. D. De Vivo, R. Finkel   +22 more
semanticscholar   +3 more sources

Mesenchymal stromal cells ameliorate diabetes‐induced muscle atrophy through exosomes by enhancing AMPK/ULK1‐mediated autophagy

Journal of Cachexia, Sarcopenia and Muscle, 2023
Diabetes and obesity are associated with muscle atrophy that reduces life quality and lacks effective treatment. Mesenchymal stromal cell (MSC)‐based therapy can ameliorate high fat‐diet (HFD) and immobilization (IM)‐induced muscle atrophy in mice ...
Jia Song, Jidong Liu, C. Cui, Huiqing Hu, N. Zang, Mengmeng Yang, Jingwen Yang, Ying Zou, Jinquan Li, Lingshu Wang, Qin He, Xinghong Guo, Ruxing Zhao, Fei Yan, Fuqiang Liu, X. Hou, Zheng Sun, Li Chen   +17 more
semanticscholar   +1 more source

Hierarchical Fully Convolutional Network for Joint Atrophy Localization and Alzheimer's Disease Diagnosis Using Structural MRI

IEEE Transactions on Pattern Analysis and Machine Intelligence, 2020
Structural magnetic resonance imaging (sMRI) has been widely used for computer-aided diagnosis of neurodegenerative disorders, e.g., Alzheimer's disease (AD), due to its sensitivity to morphological changes caused by brain atrophy.
Chunfeng Lian, Mingxia Liu, Jun Zhang, D. Shen   +3 more
semanticscholar   +1 more source

Risdiplam in Type 1 Spinal Muscular Atrophy.

New England Journal of Medicine, 2021
BACKGROUND Type 1 spinal muscular atrophy is a rare, progressive neuromuscular disease that is caused by low levels of functional survival of motor neuron (SMN) protein. Risdiplam is an orally administered, small molecule that modifies SMN2 pre-messenger
G. Baranello, B. Darras, J. Day, N. Deconinck, A. Klein, R. Masson, E. Mercuri, K. Rose, M. El-Khairi, M. Gerber, K. Gorni, O. Khwaja, Heidemarie Kletzl, R. Scalco, T. Seabrook, P. Fontoura, L. Servais   +16 more
semanticscholar   +1 more source

Phenomenological model of diffuse global and regional atrophy using finite-element methods [PDF]

, 2006
The main goal of this work is the generation of ground-truth data for the validation of atrophy measurement techniques, commonly used in the study of neurodegenerative diseases such as dementia.
Camara, O., Cash, D.M., Crum, W.R., Fox, N.C., Hill, D.L.G., Ridgway, G.R., Scahill, R.I., Schnabel, J.A., Schweiger, M., Sneller, B.I.   +9 more
core   +1 more source

Vulvovaginal Atrophy [PDF]

Mayo Clinic Proceedings, 2010
Vulvovaginal atrophy (VVA) is a common and underreported condition associated with decreased estrogenization of the vaginal tissue. Symptoms include dryness, irritation, soreness, and dyspareunia with urinary frequency, urgency, and urge incontinence. It can occur at any time in a woman's life cycle, although more commonly in the postmenopausal phase ...
Maire B, Mac Bride, Deborah J, Rhodes, Lynne T, Shuster   +2 more
openaire   +2 more sources

Structures of α-synuclein filaments from multiple system atrophy

Nature, 2020
Synucleinopathies, which include multiple system atrophy (MSA), Parkinson’s disease, Parkinson’s disease with dementia and dementia with Lewy bodies (DLB), are human neurodegenerative diseases1. Existing treatments are at best symptomatic. These diseases
M. Schweighauser, Yang Shi, A. Tarutani, F. Kametani, A. Murzin, B. Ghetti, T. Matsubara, T. Tomita, T. Ando, K. Hasegawa, S. Murayama, Mari Yoshida, M. Hasegawa, S. Scheres, M. Goedert   +14 more
semanticscholar   +1 more source

Long-Term Effects of Helicobacter pylori Eradication on Metachronous Gastric Cancer Development

Gut and Liver, 2018
Background/AimsGastric mucosal atrophy and intestinal metaplasia due to Helicobacter pylori infection are the main precursor lesions of gastric cancer. The aim of this study was to evaluate the long-term effects of H.
Seung Jun Han, Sang Gyun Kim, Joo Hyun Lim, Ji Min Choi, Sooyeon Oh, Jae Yong Park, Jung Kim, Joo Sung Kim, Hyun Chae Jung   +8 more
doaj   +1 more source

PTEN‐AKT pathway attenuates apoptosis and adverse remodeling in ponatinib‐induced skeletal muscle toxicity following BMP‐7 treatment

Physiological Reports, 2023
Tyrosine kinase inhibitors (TKIs) including ponatinib are commonly used to treat cancer patients. Unfortunately, TKIs induce cardiac as well as skeletal muscle dysfunction as a side effect.
Ayushi Srivastava, Dinender K. Singla
doaj   +1 more source