Results 11 to 20 of about 698,332 (299)

Magnetic resonance imaging measures of brain volumes across the EXPEDITION trials in mild and moderate Alzheimer's disease dementia

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022
Introduction Solanezumab is a monoclonal antibody that preferentially binds soluble amyloid beta and promotes its clearance from the brain. The aim of this post hoc analysis was to assess the effect of low‐dose solanezumab (400 mg) on global brain volume
Diana Otero Svaldi, Ixavier A. Higgins, Karen C. Holdridge, Roy Yaari, Michael Case, Luc Bracoud, David Scott, Sergey Shcherbinin, John R. Sims   +8 more
doaj   +1 more source

Altered Ca²⁺ Handling and Oxidative Stress Underlie Mitochondrial Damage and Skeletal Muscle Dysfunction in Aging and Disease

Metabolites, 2021
Skeletal muscle contraction relies on both high-fidelity calcium (Ca2+) signals and robust capacity for adenosine triphosphate (ATP) generation. Ca2+ release units (CRUs) are highly organized junctions between the terminal cisternae of the sarcoplasmic ...
Antonio Michelucci, Chen Liang, Feliciano Protasi, Robert T. Dirksen   +3 more
doaj   +1 more source

Disuse-induced skeletal muscle atrophy in disease and non-disease states in humans: mechanisms, prevention, and recovery strategies.

American Journal of Physiology - Cell Physiology, 2022
Decreased skeletal muscle contractile activity (disuse) or unloading leads to muscle mass loss, also known as muscle atrophy. The balance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB) is the primary determinant of skeletal ...
E. Nunes, Tanner Stokes, James McKendry, B. Currier, Stuart M Phillips   +4 more
semanticscholar   +1 more source

A Rare Case of Sporadic Inclusion Body Myositis (s-IBM) [PDF]

Journal of Clinical and Diagnostic Research, 2016
Sporadic inclusion body myositis (s-IBM) is an acquired inflammatory myopathy. Clinical presentation is variable. The usual presentation is progressive weakness and atrophy of the arms and leg muscles, especially of the quadriceps femoris which is ...
Sourya Acharya, Samarth Shukla, Pritum Kitey, Shameem Khan, SN Mahajan   +4 more
doaj   +1 more source

Fractal Dimension of Silhouette Magnetic Resonance Brain Images as a Measure of Age-Associated Changes in Cerebral Hemispheres

Düzce Tıp Fakültesi Dergisi, 2023
Aim: The aim of the present study was to characterize age-associated changes in the spatial configuration of cerebral hemispheres (including changes in spatial complexity and space-filling capacity) using fractal analysis of silhouette magnetic resonance
Oleksandr Stepanenko, Nataliia Maryenko
doaj   +1 more source

Hierarchical Fully Convolutional Network for Joint Atrophy Localization and Alzheimer's Disease Diagnosis Using Structural MRI

IEEE Transactions on Pattern Analysis and Machine Intelligence, 2020
Structural magnetic resonance imaging (sMRI) has been widely used for computer-aided diagnosis of neurodegenerative disorders, e.g., Alzheimer's disease (AD), due to its sensitivity to morphological changes caused by brain atrophy.
Chunfeng Lian, Mingxia Liu, Jun Zhang, D. Shen   +3 more
semanticscholar   +1 more source

N-Chlorotaurine Reduces the Lung and Systemic Inflammation in LPS-Induced Pneumonia in High Fat Diet-Induced Obese Mice

Metabolites, 2022
Lung infection can evoke pulmonary and systemic inflammation, which is associated with systemic severe symptoms, such as skeletal muscle wasting. While N-chlorotaurine (also known as taurine chloramine; TauCl) has anti-inflammatory effects in cells, its ...
Nguyen Khanh Hoang, Eiji Maegawa, Shigeru Murakami, Stephen W. Schaffer, Takashi Ito   +4 more
doaj   +1 more source

PD-1 Alleviates Cisplatin-Induced Muscle Atrophy by Regulating Inflammation and Oxidative Stress

Antioxidants, 2022
Skeletal muscle atrophy is an important characteristic of cachexia, which can be induced by chemotherapy and significantly contributes to functional muscle impairment.
Xiaoguang Liu, Miaomiao Xu, Yang Yu, Yingjie Chen, Xinyu Weng, Lin Zhu   +5 more
doaj   +1 more source

Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy

Cells, 2020
Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via PI3K/Akt/mTOR and PI3K/Akt/GSK3β pathways. PI3K/Akt can also inhibit
Tadashi Yoshida, P. Delafontaine
semanticscholar   +1 more source

Triptolide prevents LPS‐induced skeletal muscle atrophy via inhibiting NF‐κB/TNF‐α and regulating protein synthesis/degradation pathway

British Journal of Pharmacology, 2021
Increasing evidence suggests systemic inflammation‐caused skeletal muscle atrophy as a major clinical feature of cachexia. Triptolide obtained from Tripterygium wilfordii Hook F possesses potent anti‐inflammatory and immunosuppressive effects.
W. Fang, Y. Tseng, Tzu-Ying Lee, Yin-Chih Fu, Wan-Hsuan Chang, Wan-Wen Lo, Chih-Lung Lin, Y. Lo   +7 more
semanticscholar   +1 more source