Results 21 to 30 of about 32,506 (196)

Impact of Earlier Diagnosis in Cardiac ATTR Amyloidosis Over the Course of 20 Years [PDF]

Circulation, 2022
Adam Ioannou, Julian Gillmore, Daniel Knight   +2 more
exaly   +2 more sources

A Descriptive Analysis of ATTR Amyloidosis in Spain from the Transthyretin Amyloidosis Outcomes Survey. [PDF]

, 2021
Introduction Transthyretin amyloidosis (ATTR amyloidosis) is a clinically heterogeneous disease caused by mutations in the transthyretin (TTR) gene or aggregation of wild-type transthyretin (ATTRwt).
Gonzalez-Costello, Jose, Muñoz Beamud, Francisco, González Moreno, Juan, Cisneros Barroso, Eugenia, Campistol, Josep María, González-Moreno, Juan, Amass, Leslie, Chapman, Doug, Fernandez-Torron, Roberto, Cisneros-Barroso, Eugenia, Munoz-Beamud, Francisco, Fernández Torrón, Roberto, González Costello, José, Losada-López, Inés, Losada López, Inés, García Pavía, Pablo, Garcia-Pavia, Pablo   +16 more
core   +3 more sources

Diflunisal for ATTR Cardiac Amyloidosis [PDF]

Congestive Heart Failure, 2012
©2012 Wiley Periodicals Inc.Transthyretin (TTR) cardiac amyloidosis is an important, often under‐recognized and potentially modifiable cause of heart failure with a preserved ejection fraction. The only proven treatment is liver or combined heart/liver transplantation, which, although effective, is not suitable for the vast majority of older adults ...
Adam, Castaño, Stephen, Helmke, Julissa, Alvarez, Susan, Delisle, Mathew S, Maurer   +4 more
openaire   +2 more sources

Transthyretin cardiac amyloidosis in patients after TAVR: clinical and echocardiographic findings and long term survival

ESC Heart Failure, 2021
Aims The aim of this study was to examine the prevalence of amyloid transthyretin (ATTR) cardiac amyloidosis in patients 1–2 years after trans‐catheter aortic valve replacement (TAVR) and to assess their clinical and echocardiographic outcome and long ...
Sara Shimoni, Meital Zikri, Dan Haberman, Shay Livschitz, Sagi Tshori, Yacov Fabricant, Valery Meledin, Gera Gandelman, Sorel Goland, Jacob George   +9 more
doaj   +1 more source

Cardiac Transthyretin-derived Amyloidosis: An Emerging Target in Heart Failure with Preserved Ejection Fraction?

Cardiac Failure Review, 2020
Heart failure with preserved ejection fraction (HFpEF) comprises half of the heart failure population. A specific, but underdiagnosed, cause for HFpEF is transthyretin-derived (ATTR) amyloidosis.
Sebastiaan HC Klaassen, Dirk J van Veldhuisen, Hans LA Nienhuis, Maarten P van den Berg, Bouke PC Hazenberg, Peter van der Meer   +5 more
doaj   +1 more source

Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis

Nature Communications, 2021
ATTR amyloidosis causes heart failure through the accumulation of misfolded transthyretin in cardiac muscle. Here the authors report a mouse model of ATTR amyloidosis and demonstrate the involvement of protease activity in ATTR amyloid deposition.
Ivana Slamova, Rozita Adib, Stephan Ellmerich, Michal R. Golos, Janet A. Gilbertson, Nicola Botcher, Diana Canetti, Graham W. Taylor, Nigel Rendell, Glenys A. Tennent, Guglielmo Verona, Riccardo Porcari, P. Patrizia Mangione, Julian D. Gillmore, Mark B. Pepys, Vittorio Bellotti, Philip N. Hawkins, Raya Al-Shawi, J. Paul Simons   +18 more
doaj   +1 more source

Avoiding misdiagnosis: expert consensus recommendations for the suspicion and diagnosis of transthyretin amyloidosis for the general practitioner

BMC Family Practice, 2020
Background Transthyretin amyloidosis (also known as ATTR amyloidosis) is a systemic, life-threatening disease characterized by transthyretin (TTR) fibril deposition in organs and tissue. A definitive diagnosis of ATTR amyloidosis is often a challenge, in
Morie Gertz, David Adams, Yukio Ando, João Melo Beirão, Sabahat Bokhari, Teresa Coelho, Raymond L. Comenzo, Thibaud Damy, Sharmila Dorbala, Brian M. Drachman, Marianna Fontana, Julian D. Gillmore, Martha Grogan, Philip N. Hawkins, Isabelle Lousada, Arnt V. Kristen, Frederick L. Ruberg, Ole B. Suhr, Mathew S. Maurer, Jose Nativi-Nicolau, Candida Cristina Quarta, Claudio Rapezzi, Ronald Witteles, Giampaolo Merlini   +23 more
doaj   +1 more source

Conjunctival lymphangiectasia and retinal angiopathy in hereditary transthyretin amyloidosis

International Journal of Retina and Vitreous, 2022
Background Hereditary transthyretin amyloidosis (ATTR amyloidosis) is a rare condition where a mutation in the transthyretin gene leads to systemic deposition of amyloid.
Nikhil S. Patil, Munir M. Iqbal, Lulu L. C. D. Bursztyn   +2 more
doaj   +1 more source

Stratifying Disease Progression in Patients With Cardiac ATTR Amyloidosis [PDF]

Journal of the American College of Cardiology
Adam Ioannou, Rishi Patel, Carol Whelan   +2 more
exaly   +2 more sources

Established and candidate transthyretin amyloidosis variants identified in the Saudi population by data mining

Human Genomics, 2021
Background Familial transthyretin (TTR) amyloidosis (ATTR) is an autosomal dominant disease with significant phenotypic heterogeneity. Its prevalence in Saudi Arabia has not previously been investigated.
Mohamed Abouelhoda, Dania Mohty, Islam Alayary, Brian F. Meyer, Stefan T. Arold, Bahaa M. Fadel, Dorota Monies   +6 more
doaj   +1 more source