Results 81 to 90 of about 19,741 (278)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Two-Factor-Based Public Data Protection Scheme in Smart Ocean Management

Sensors, 2019
Nowadays, two-factor data security protection has become a research hotspot in smart ocean management. With the increasing popularity of smart ocean management, how to achieve the two-factor protection of public data resources in smart ocean management ...
Jian Shen, Xinzhao Jiang, Youngju Cho, Dengzhi Liu, Tianqi Zhou   +4 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Privacy Preserving Context Aware Publish Subscribe Systems 2013-1 [PDF]

, 2013
Publish/subscribe (pub/sub) systems support highly scalable, many to many communications among loosely coupled publishers and subscribers.Modernpub/sub systems perform message routing based on the message content and allow subscribers to receive messages
Nabeel, Mohamed, Bertino, Elisa, Buchmann, Alejandro, Appel, Stefan   +3 more
core   +1 more source

Longitude : a privacy-preserving location sharing protocol for mobile applications [PDF]

, 2011
Location sharing services are becoming increasingly popular. Although many location sharing services allow users to set up privacy policies to control who can access their location, the use made by service providers remains a source of concern.
Dong, Changyu, Changyu Dong, Naranker Dulay, Dulay, Naranker   +3 more
core   +1 more source

An Attribute-based Signature Scheme from Lattices

工程科学与技术, 2015
:Lattice attribute-based cryptography has several attractive and distinguishing features. However,a lattice attribute-based signature scheme has not yet been presented till now.Consequently,an attribute-based signature scheme from lattices was ...
李明祥, 安妮, 封二英, 庞灵
doaj  

Delegation and tracing for attribute-based cryptography

Délégation et traçage pour la cryptographie à base d'attributs Le nombre d’appareils connectés par personne a massivement augmenté lors de la dernière décennie, en particulier dans les pays occidentaux. Étant donné que la sécurité des structures connectées au réseau peut être compromise à partir de n’importe quel point d’entrée par un ...
openaire   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source