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Dissecting Trafficking and Signaling of Atypical Chemokine Receptors
2013Atypical chemokine receptors are a distinct subset of chemokine receptors able to modulate immune responses by acting as chemokine decoy/scavengers or transporters. Intracellular trafficking properties sustained by Gαi-independent signaling have emerged as a major determinant of their biological properties, which support continuous uptake, transport ...
E. Borroni +3 more
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Atypical chemokine receptors in tumor cell growth and metastasis
2020Atypical chemokine receptors (ACKRs) are seven-transmembrane cell surface protein receptors expressed in immune cells, normal mesenchymal cells, and several tumor cells. As of this writing, six ACKRs have been characterized by diverse activities. They bind both cysteine-cysteine (CC) type and cysteine-X-cysteine (CXC)-type chemokines, either alone, or ...
Bal L, Lokeshwar +2 more
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Atypical chemokine receptors in the immune system
Nature Reviews ImmunologyLeukocyte migration is a fundamental component of innate and adaptive immune responses as it governs the recruitment and localization of these motile cells, which is crucial for immune cell priming, effector functions, memory responses and immune regulation.
Iain Comerford, Shaun R. McColl
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Regulation of Breast Cancer Metastasis by Atypical Chemokine Receptors
Clinical Cancer Research, 2009Abstract The interaction between chemokines and their G-protein-coupled receptors plays an important role in promoting metastasis of different kinds of human cancers. However, the expression of an atypical chemokine receptor, CCX-CKR, which serves as a decoy receptor to attract chemokines, inhibits the growth and metastasis of breast ...
Xiaoyun, Cheng, Mien-Chie, Hung
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The biochemistry and biology of the atypical chemokine receptors
Immunology Letters, 2012A subset of chemokine receptors, initially called "silent" on the basis of their apparent failure to activate conventional signalling events, has recently attracted growing interest due to their ability to internalize, degrade, or transport ligands and thus modify gradients and create functional chemokine patterns in tissues.
G. J. Graham +4 more
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Contribution of atypical chemokine receptor 2/ackr2 in bone remodeling
Bone, 2017Bone remodeling is a tightly regulated process influenced by chemokines. ACKR2 is a decoy receptor for CC chemokines functioning as regulator of inflammatory response. In this study we investigated whether the absence of ACKR2 would affect bone phenotype and remodeling induced by mechanical loading.An orthodontic appliance was placed between incisors ...
Izabella Lucas de Abreu, Lima +9 more
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Active Shaping of Chemokine Gradients by Atypical Chemokine Receptors
2016Kathrin Werth, Reinhold Förster
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