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Atypical Chemokine Receptors in Inflammatory Disease
Current Molecular Medicine, 2009There is considerable interest in the therapeutic utility of inhibiting cellular trafficking in a variety of inflammatory diseases. Approaches including inhibition of adhesion molecule function and in particular of chemokine effector function have met with high levels of success in many models of disease but have been of less value in application to ...
Manish, Patel +2 more
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Canonical and atypical chemokine receptors in the neutrophil life cycle
Cytokine, 2023Chemokines are mainly studied for their local function in the control of leukocyte extravasation in homeostatic and inflammatory conditions. However, they have additional roles at the systemic level including the regulation of the hematopoietic process and leukocyte differentiation.
Rachele Di Donato +2 more
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Atypical chemokine receptors—“chemokine PACMANs” as new therapeutic targets in glomerulonephritis
Kidney International, 2018Inflammatory cells are recruited to sites of inflammation by chemokines. Atypical chemokine receptors regulate chemokine gradients, thereby limiting inflammation. In this issue of Kidney International, atypical chemokine receptor 2 knockouts were described to be increasingly susceptible to immune complex-mediated glomerulonephritis.
Kathrin, Eller, Alexander R, Rosenkranz
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Dissecting Trafficking and Signaling of Atypical Chemokine Receptors
2013Atypical chemokine receptors are a distinct subset of chemokine receptors able to modulate immune responses by acting as chemokine decoy/scavengers or transporters. Intracellular trafficking properties sustained by Gαi-independent signaling have emerged as a major determinant of their biological properties, which support continuous uptake, transport ...
E. Borroni +3 more
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Atypical chemokine receptors in tumor cell growth and metastasis
2020Atypical chemokine receptors (ACKRs) are seven-transmembrane cell surface protein receptors expressed in immune cells, normal mesenchymal cells, and several tumor cells. As of this writing, six ACKRs have been characterized by diverse activities. They bind both cysteine-cysteine (CC) type and cysteine-X-cysteine (CXC)-type chemokines, either alone, or ...
Bal L, Lokeshwar +2 more
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Regulation of Breast Cancer Metastasis by Atypical Chemokine Receptors
Clinical Cancer Research, 2009Abstract The interaction between chemokines and their G-protein-coupled receptors plays an important role in promoting metastasis of different kinds of human cancers. However, the expression of an atypical chemokine receptor, CCX-CKR, which serves as a decoy receptor to attract chemokines, inhibits the growth and metastasis of breast ...
Xiaoyun, Cheng, Mien-Chie, Hung
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Contribution of atypical chemokine receptor 2/ackr2 in bone remodeling
Bone, 2017Bone remodeling is a tightly regulated process influenced by chemokines. ACKR2 is a decoy receptor for CC chemokines functioning as regulator of inflammatory response. In this study we investigated whether the absence of ACKR2 would affect bone phenotype and remodeling induced by mechanical loading.An orthodontic appliance was placed between incisors ...
Izabella Lucas de Abreu, Lima +9 more
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