Results 81 to 90 of about 28,527 (253)

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Re: Chemokines in Cancer

Journal of Urological Surgery, 2016
Chemokines are chemotactic cytokines that regulate the trafficking and positioning of cells by activating the seven-transmembrane spanning G protein-coupled chemokine receptors (GPCR) or non G protein-coupled seven-transmembrane spanning receptors called
Fehmi Narter
doaj   +1 more source

Reassessing the adrenomedullin scavenging function of ACKR3 in lymphatic endothelial cells.

PLoS ONE, 2023
Atypical chemokine receptor 3 (ACKR3) is a scavenger of the chemokines CXCL11 and CXCL12 and of several opioid peptides. Additional evidence indicates that ACKR3 binds two other non-chemokine ligands, namely the peptide hormone adrenomedullin (AM) and ...
Elena C Sigmund, Aline Bauer, Barbara D Jakobs, Hazal Tatliadim, Carlotta Tacconi, Marcus Thelen, Daniel F Legler, Cornelia Halin   +7 more
doaj   +1 more source

Resolution of inflammation: what Controls its Onset? [PDF]

, 2016
The authors would like to acknowledge the funding agencies, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil), Comissão de Aperfeiçoamento de Pessoal do Ensino Superior (CAPES, Brazil), Fundação do Amparo a Pesquisa de Minas ...
Alessandri, Anderson, Anderson, Anderson, Aparicio-Soto, Arita, Averill, Baeuerle, Bamias, Bandeira-Melo, Baumgart, Bazzoni, Bersudsky, Besedovsky, Bhatt, Biswas, Bohuslav, Boldin, Boldin, Bonizzi, Bozyk, Brancaleone, Brancaleone, Branzk, Brophy, Brudecki, Brun, Buckley, Burne, Butler, Campbell, Cataldi, Celik, Chan, Cheng, Chian, Chiang, Cipollone, Claria, Corbin, Coskun, Criollo, Csoka, Dalli, Dalli, Damo, Danese, Dean, Dean, Diaz-Ochoa, Dupaul-Chicoine, Eke Gungor, El Gazzar, El-Salhy, Erlinger, Etzrodt, Fadok, Fiorucci, Fong, Fu, Fukunaga, Garcia-Romo, Gasser, Gastardelo, Gearing, Getting, Gilroy, Gobbetti, Gresnigt, Greten, Hakkim, Haq, Harrington, Harty, Hasko, Haworth, Haworth, Hayden, Headland, Headland, Helgadottir, Heppner, Hodges, Hoffmann, Hong, Hood, Hosokawa, Hsu, Hsu, Huang, Huxford, Johnnidis, Jurkin, Kahlenberg, Karin, Katakami, Kehl-Fie, Kim, Knight, Knight, Koroskenyi, Kuhl, Kunkel, Lagos, Lande, Lardone, Lawrence, Lawrence, Lawrence, Lee, Leoni, Letterio, Levy, Levy, Li, Liu, Liu, Lood, Lopes, Loser, Lu, Ma, Ma, Ma, MacKenzie, Maderna, Malawista, Mangino, Markworth, Martinod, Mazumder, McQuibban, McQuibban, McQuibban, Medina-Contreras, Medzhitov, Medzhitov, Mirakaj, Moelants, Monteleone, Monteleone, Montero-Melendez, Montero-Melendez, Montero-Melendez, Morris, Morris, Muxel, Nakahira, Nathan, Nathan, Nemeth, Newton, Nibbs, Oeckinghaus, Opie, Ortega-Gomez, Otsuka, Ouyang, O’Connell, Parks, Pavlov, Pederzoli-Ribeil, Pepper, Perretti, Perretti, Perretti, Perretti, Perry, Pillai, Planaguma, Planagumà, Podolska, Porta, Rau, Riva, Ronchetti, Ryckman, Saccani, Saitoh, Samuelsson, Saraiva, Savchenko, Scannell, Schaljo, Schauer, Schiopu, Schwab, Schwartz, Sena, Sena, Serhan, Serhan, Serhan, Serhan, Serhan, Serhan, Serhan, Serhan, Shaked, Shibata, Shimizu, Sohnle, Sousa, Souza, Souza, Souza, Souza, Sroussi, Sroussi, Sroussi, Sroussi, Stables, Sugimoto, Sun, Sun, Surh, Taganov, Takagi, Tam, Terrin, Trostrup, Vacchini, Vachier, Vago, Vallabhapurapu, van den Bergh, Van den Steen, van der Meer, Vancheri, Vane, Villani, Viola, Vogl, Volz, Vong, Vordenbaumen, Wallace, Wang, Warnatsch, Wilborn, Wilson, Wong, Woo, Wu, Xiao, Youssef, Zaki, Zhang, Zhong, Zhou, Ziegler-Heitbrock   +250 more
core   +3 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Concepts of GPCR-controlled navigation in the immune system

, 2019
G-protein-coupled receptor (GPCR) signaling is essential for the spatiotemporal control of leukocyte dynamics during immune responses. For efficient navigation through mammalian tissues, most leukocyte types express more than one GPCR on their surface ...
Boneschansker L, Brandt SL, Chan EC, Filippo K, Freedman NJ, Hjorto GM, Hons M, Katakai T, Kitayama J, Lemos C, Ley K, Miyabe Y, Moussavi‐Harami SF, Proudfoot AEI, Purvanov V, Rot A, Scheiermann C, Schwarz J, Sokol CL, Sotsios Y, Steury MD, Takeda A, Thiriot A, Tomhave ED, Wang Y, Yanagihara S, Zhang Y   +26 more
core   +1 more source

Insights on adaptive and innate immunity in canine leishmaniosis [PDF]

, 2016
Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities.
Abi Abdallah, Alexander, Catchpole, DAMER P. BLAKE, de Souza Carmo, Green, Kensil, LAIA SOLANO-GALLEGO, Lopez, Margarito, Ordeix, Pinelli, Pitta, Quinnell, Sadick, Sanchez, SHAZIA HOSEIN, Silva, Vouldoukis, Wakelin   +19 more
core   +4 more sources

CXC Chemokine‐Driven Vascular Reprogramming: Modulating Tumor Vasculature to Boost Therapeutic Response

Advanced Science, EarlyView.
Tumor vascular remodeling is discussed from a chemokine‐centered perspective. This review summarizes the bidirectional, temporal, and tissue‐specific roles of CXC chemokines in regulating vascular function and immune accessibility. A functional vascular normalization score is introduced as a conceptual framework to integrate dynamic vascular and immune
Hongdan Chen, Yinde Huang, Juntong Wu, Ziying Yi, Yao Li, Zeyu Yang, Fan Zhang, Chong Li   +7 more
wiley   +1 more source

Human Adipose Tissue-Derived Mesenchymal Stem Cells Target Brain Tumor-Initiating Cells. [PDF]

PLoS ONE, 2015
In neuro-oncology, the biology of neural stem cells (NSCs) has been pursued in two ways: as tumor-initiating cells (TICs) and as a potential cell-based vehicle for gene therapy.
Seung Ah Choi, Ji Yeoun Lee, Sung Eun Kwon, Kyu-Chang Wang, Ji Hoon Phi, Jung Won Choi, Xiong Jin, Ja Yun Lim, Hyunggee Kim, Seung-Ki Kim   +9 more
doaj   +1 more source

Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell–Targeted Therapies

Arthritis &Rheumatology, EarlyView.
Sjögren disease (SjD) is a common systemic autoimmune disorder characterized by inflammation of the exocrine glands, resulting in dryness. Patients frequently exhibit extraglandular manifestations affecting various organ systems. To date, there are no US Food and Drug Administration (FDA)‐approved disease‐modifying therapies for SjD. In this review, we
Rachael A. Gordon, Sara S. McCoy
wiley   +1 more source