Results 111 to 120 of about 25,762 (279)

The genetics of atypical hemolytic uremic syndrome [PDF]

Medizinische Genetik, 2018
Abstract Atypical hemolytic uremic syndrome (aHUS) is a disorder characterized by thrombocytopenia and microangiopathic hemolytic anemia due to endothelial injury. aHUS is felt to be caused by defective complement regulation due to underlying genetic mutations in complement regulators or activators, most often of the alternative pathway.
Feitz, W.JC., van de Kar, N.CA.J., Orth-Höller, D., van den Heuvel, L.PJ.W., Licht, C.   +4 more
openaire   +3 more sources

Soluble C5b‐9 (sC5b‐9) in Pediatrics—A Clinical Assessment

Journal of Clinical Laboratory Analysis, Volume 39, Issue 23, December 2025.
The sc5b9 assay is a simple laboratory‐developed test that can be used in specific patients to monitor the course of disease, severity, or response to therapy. Future studies using this assay, which show excellent adaptability to a clinical laboratory, will reveal the multiple uses of testing for complement activation.
Ridwan B. Ibrahim, Radwa Almamoun, Sarah E. Sartain, Sridevi Devaraj   +3 more
wiley   +1 more source

Multiple Myeloma as the Underlying Cause of Thrombotic Microangiopathy Leading to Acute Kidney Injury: Revisiting a Very Rare Entity

Journal of Investigative Medicine High Impact Case Reports, 2017
Thrombotic microangiopathy (TMA) describes a pathological process of microvascular thrombosis, consumptive thrombocytopenia, and microangiopathic hemolytic anemia, leading to end-organ ischemia and infarction, affecting particularly the kidney and brain.
Savneek Chugh MD, Asim Kichloo MD, Firas Jafri MD, Liga Yusvirazi MD, Robert Lerner MD   +4 more
doaj   +1 more source

Maternal Renal Function During Pregnancy and the Early Postpartum Period in Normotensive and Hypertensive Pregnancies

Journal of Obstetrics and Gynaecology Research, Volume 51, Issue 12, December 2025.
ABSTRACT Aim We aimed to assess renal function trends during pregnancy and the early postpartum period and establish trimester‐specific reference ranges for maternal renal function parameters in Japan, including comparisons with pregnancies complicated by hypertensive disorders of pregnancy (HDP) and preeclampsia. Methods This multicenter retrospective
Takafumi Ushida, Satoru Katsuki, Kazuya Fuma, Sho Tano, Seiko Matsuo, Shigeru Yoshida, Mamoru Yamashita, Hiroaki Kajiyama, Tomomi Kotani   +8 more
wiley   +1 more source

Eculizumab safely reverses neurologic impairment and eliminates need for dialysis in severe atypical hemolytic uremic syndrome

Clinical Pharmacology: Advances and Applications, 2011
Maro Ohanian, Christian Cable, Kathleen HalkaDepartment of Hematology and Oncology, Scott and White Healthcare, The Texas A&M Health Science Center College of Medicine, Temple, TX, USAAbstract: This case report describes how eculizumab reversed ...
Ohanian M, Cable CC, Halka KK
doaj  

Complement System Part II: Role in Immunity [PDF]

, 2015
International audienceThe complement system has been considered for a long time as a simple lytic cascade, aimed to kill bacteria infecting the host organism.
Fremeaux-Bacchi, Veronique, Halbwachs-Mecarelli, Lise, Merle, Nicolas S., Noe, Remi, Roumenina, Lubka T.   +4 more
core   +5 more sources

The Impact of Complement Factor H‐Related Protein Gene Deletions on Kidney Transplantation

Scandinavian Journal of Immunology, Volume 102, Issue 6, December 2025.
In this study, we found that rs7542235 allele G tags a deletion of the CFHR1 gene. We also found that rs6677604 allele A tags a deletion of the whole CFHR3–1 locus. The plasma proteomics studies show that both variants are associated with an altered expression of FH/FHR proteins thus revealing a novel level of intricate regulation of the complement ...
Salla Markkinen, A. Inkeri Lokki, Ilkka Helanterä, Jarmo Ritari, Jukka Partanen, Seppo Meri, Kati Hyvärinen   +6 more
wiley   +1 more source

SUCCESSFUL TREATMENT FOR ATYPICAL HEMOLYTIC UREMIC SYNDROME IN A PUERPERA

Общая реаниматология, 2016
Objective: to show the problems of differential diagnosis and treatment of atypical hemolytic-uremic syndrome in a 23-year-old patient.Results. Eculizumab (Soliris), (Alexon Pharmaceuticals Inc., USA) that is a glycosylated humanized monoclonal antibody ...
O. N. Ulitkina, Zh. S. Filippovskaya, E. I. Prokopenko, A. M. Ovezov, V. V. Likhvantsev   +4 more
doaj   +1 more source

Voice of a caregiver: call for action for multidisciplinary teams in the care for children with atypical hemolytic uremic syndrome [PDF]

, 2023
Linda Burke, Sidharth Kumar Sethi, Olivia Boyer, Christoph Licht, Mignon McCulloch, Raghav Shah, Valérie A. Luyckx, Rupesh Raina   +7 more
openalex   +1 more source

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

Veterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis, Gad Baneth, Silvia Colombo, Filipe Dantas‐Torres, Lluís Ferrer, Alessandra Fondati, Guadalupe Miró, Laura Ordeix, Domenico Otranto, Chiara Noli   +9 more
wiley   +1 more source