Results 41 to 50 of about 25,762 (279)
Blood, 2023 Key Points • We prove in genotype-matched complement-mediated aHUS cohorts that C5 inhibition results in a statistical improvement in ESKD-free survival.• We demonstrate that biallelic pathogenic mutations in EXOSC3 cause eculizumab nonresponsive aHUS.
V. Brocklebank +136 more
semanticscholar +1 more source
Atypical Hemolytic Uremic Syndrome
Pediatric Clinics of North America, 2018 Atypical hemolytic uremic syndrome is a rare life-threatening disease of unregulated complement activation. Untreated, the prognosis is generally poor; more than one-half of patients die or develop end-stage renal disease within 1 year. Atypical hemolytic uremic syndrome is characterized by thrombotic microangiopathy with evidence of hemolysis ...
Bradley P. Dixon, Ralph A. Gruppo
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Cureus, 2023 Atypical hemolytic uremic syndrome (aHUS) is a type of thrombotic microangiopathy and is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney failure. The complement cascade plays an integral role in aHUS.
Kamran Shahid, S. Qayyum
semanticscholar +1 more source
Internal medicine, 2023 A 34-year-old Japanese man presented with blurred vision, headache, nausea, anemia, thrombocytopenia, and severe renal dysfunction. Thrombotic microangiopathy was initially suspected to have been caused by malignant hypertension.
Kosuke Osawa +13 more
semanticscholar +1 more source
Influenza B-Associated Atypical Hemolytic Uremic Syndrome [PDF]
Revista Portuguesa de Nefrologia e Hipertensão, 2022 Hemolytic uremic syndrome (HUS) triggered by influenza virus (iHUS) is rare. Influenza A infections have been described to trigger atypical HUS (aHUS) in individuals with an underlying genetic complement dysregulation. To date there are only few reports
Lia Mano +5 more
doaj +1 more source
American Journal of Perinatology Reports, 2023 Pregnancy-associated atypical hemolytic uremic syndrome (P-aHUS) is a rare condition characterized by microangiopathic hemolytic anemia and kidney injury from thrombotic microangiopathy.
Alex Domínguez-Vargas +6 more
semanticscholar +1 more source
Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice [PDF]
, 2019 Atypical hemolytic uremic syndrome (aHUS) is frequently associated in humans with loss-of-function mutations in complement-regulating proteins or gain-of-function mutations in complement-activating proteins.
Atkinson, John P +11 more
core +3 more sources
How I diagnose and treat atypical hemolytic uremic syndrome.
Blood, 2022 Our understanding and management of atypical haemolytic uremic syndrome (HUS) has dramatically improved in the last decade. Atypical HUS has been established as a prototypic disease resulting from a dysregulation of the complement alternative C3 ...
F. Fakhouri +2 more
semanticscholar +1 more source
Anti-factor H antibody and its role in atypical hemolytic uremic syndrome
Frontiers in Immunology, 2022 Atypical hemolytic uremic syndrome (aHUS) an important form of a thrombotic microangiopathy (TMA) that can frequently lead to acute kidney injury (AKI). An important subset of aHUS is the anti-factor H associated aHUS.
R. Raina +7 more
semanticscholar +1 more source
How I treat thrombotic thrombocytopenic purpura and atypical haemolytic uraemic syndrome [PDF]
, 2014 Thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome (aHUS) are acute, rare life-threatening thrombotic microangiopathies that require rapid diagnosis and treatment.
Goodship, T, Scully, M
core +1 more source