Results 51 to 60 of about 8,784 (177)

Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

Haematologica, 2017
Paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome are diseases of excess activation of the alternative pathway of complement that are treated with eculizumab, a humanized monoclonal antibody against the terminal complement ...
Xuan Yuan, Eleni Gavriilaki, Jane A. Thanassi, Guangwei Yang, Andrea C. Baines, Steven D. Podos, Yongqing Huang, Mingjun Huang, Robert A. Brodsky   +8 more
doaj   +1 more source

Pregnancy in Women with Atypical Hemolytic Uremic Syndrome [PDF]

Nephron, 2021
<b><i>Background:</i></b> Pregnancy outcomes in patients with atypical hemolytic uremic syndrome (aHUS) are not well-documented. Here, we present characteristics of and outcomes for patients with aHUS who became pregnant while enrolled in the Global aHUS Registry.
Eric, Rondeau, Gianluigi, Ardissino, Marie-Pierre, Caby-Tosi, Imad, Al-Dakkak, Fadi, Fakhouri, Benjamin, Miller, Marie, Scully   +6 more
openaire   +2 more sources

Case Series of 3 Patients Diagnosed With Atypical Hemolytic Uremic Syndrome Successfully Treated With Steroids, Plasmapheresis, and Rituximab

Canadian Journal of Kidney Health and Disease, 2017
Rationale: Atypical hemolytic uremic syndrome, which has a high probability of chronic kidney disease, morbidity, and mortality, needs to be promptly recognized when patients present with microangiopathic hemolysis.
Jeffery M. Patterson, Lauren Bolster, Loree Larratt   +2 more
doaj   +1 more source

Clinical practice guidelines for the management of atypical haemolytic uraemic syndrome in the United Kingdom

, 2010
Atypical haemolytic uraemic syndrome (aHUS) is associated with a poor prognosis with regard to survival at presentation, recovery of renal function and transplantation.
Sam Machin, ?, ?, Machin, Sam, Tim H. J. Goodship, Goodship, Tim H J, Stephen J. Wigmore, Taylor, C Mark, Wigmore, Stephen J, C. Mark Taylor   +8 more
core   +1 more source

Infection frequently triggers thrombotic microangiopathy in patients with preexisting risk factors : a single-institution experience

, 2010
Thrombotic microangiopathies are rare conditions characterized by microangiopathic hemolytic anemia, microthrombi, and multiorgan insult. The disorders, which include hemolytic uremic syndrome and thrombotic thrombocytopenic purpura, are often acute and ...
Douglas, K.W., Green, R., Douglas, Kenneth W., Pollock, K.G.J., Pollock, Kevin G.J., Catlow, Jamie, Young, D., Catlow, J., Young, David, Green, Rachel   +9 more
core   +1 more source

Atypical Hemolytic-Uremic Syndrome: Genetic Basis, Clinical Manifestations, and a Multidisciplinary Approach to Management

, 2023
Keval Yerigeri,1 Saurav Kadatane,2 Kai Mongan,3 Olivia Boyer,4 Linda LG Burke,5 Sidharth Kumar Sethi,6 Christoph Licht,7 Rupesh Raina8 1Department of Internal Medicine-Pediatrics, Case Western Reserve University/The MetroHealth System, Cleveland, OH, USA;
Boyer O, Burke LL, Yerigeri K, Sethi SK, Kadatane S, Mongan K, Licht C, Raina R   +7 more
core  

Acute ST-Segment Elevation Myocardial Infarction as Initial Presentation of Atypical Hemolytic-Uremic Syndrome

JACC: Case Reports, 2021
A young woman presented with an acute ST-segment elevation myocardial infarction. Her clinical course was complicated by cardiogenic shock and acute renal failure. Work-up revealed thrombocytopenia and hemolytic anemia.
Edward Chau, MD, MS, Shiqian Li, MD, Peter Z. Xu, MD, Grace X. Li, MD, Wesley Ghasem, MD, Ilene C. Weitz, MD, Brittney K. DeClerck, MD, Eugene C. DePasquale, MD, Bassam Yaghmour, MD   +8 more
doaj   +1 more source

Purtscher-Like Retinopathy Associated with Atypical Hemolytic Uremic Syndrome

, 2017
A 25-year-old woman presented with acute bilateral blurred vision and history of headache, dizziness, and syncope for three days. Her visual acuity was 20/60 in both eyes.
Mesut Ayer, Ozturk, Savaş, Ustaoglu, Melih, Solmaz, Nilgun, Savaş Öztürk, Ayer, Mesut, Feyza Önder, Nilgün Solmaz, Melih Ustaoğlu, Onder, Feyza   +9 more
core   +1 more source

Critical Appraisal Of Eculizumab For Atypical Hemolytic Uremic Syndrome [PDF]

, 2017
The biology of atypical hemolytic uremic syndrome has been shown to involve inability to limit activation of the alternative complement pathway, with subsequent damage to systemic endothelial beds and the vasculature, resulting in the prototypic findings
Palma, Lilian M. Pereira; Langman, Craig B.   +2 more
core   +1 more source

Reduced membrane attack complex formation in umbilical cord blood during Eculizumab treatment of the mother: a case report

BMC Nephrology, 2019
Background Atypical hemolytic uremic syndrome (aHUS) is a disorder of the microvasculature with hemolytic anemia, thrombocytopenia and acute kidney injury.
Subagini Nagarajah, Martin Tepel, Christian Nielsen, Kristian Assing, Yaseelan Palarasah, Lise Lotte Torvin Andersen, Lotte Borg Lange, Claus Bistrup   +7 more
doaj   +1 more source