Results 31 to 40 of about 13,368 (153)

Early Freezing of Gait: Atypical versus Typical Parkinson Disorders

Parkinson's Disease, 2015
In 18 months, 850 patients were referred to Muhammad Ali Parkinson Center (MAPC). Among them, 810 patients had typical Parkinson disease (PD) and 212 had PD for ≤5 years. Among the 212 patients with early PD, 27 (12.7%) had freezing of gait (FOG).
Abraham Lieberman, Aman Deep, Rohit Dhall, An Tran, Ming-Jai Liu   +4 more
doaj   +1 more source

Multi-modal rehabilitation therapy in Parkinson's disease and related disorders

Annals of Indian Academy of Neurology, 2023
Long-term use of dopaminergic therapy in Parkinson's disease (PD) is associated with reduction in efficacy and disabling dyskinesias. The current medical or surgical treatment modalities are ineffective for atypical parkinsonism syndromes.
Alvee Saluja, Vinay Goyal, Rajinder K Dhamija   +2 more
doaj   +1 more source

PLA2G6 Mutations Related to Distinct Phenotypes: A New Case with Early-onset Parkinsonism

Tremor and Other Hyperkinetic Movements, 2016
Background: PLA2G6-associated neurodegeneration (PLAN) is a recessive neurodegenerative disorder characterized by three distinct phenotypes: infantile neuroaxonal dystrophy (INAD), atypical neuroaxonal dystrophy (atypical NAD), and PLA2G6-related ...
Anamika Giri, Gamze Guven, Hasmet Hanagasi, Ann-Kathrin Hauser, Nihan Erginul-Unaltuna, Basar Bilgic, Hakan Gurvit, Peter Heutink, Thomas Gasser, Ebba Lohmann, Javier Simón-Sánchez   +10 more
doaj   +1 more source

Clinical Variability of SYNJ1-Associated Early-Onset Parkinsonism

Frontiers in Neurology, 2021
Autosomal recessive early-onset parkinsonism is clinically and genetically heterogeneous. Mutations of three genes, PRKN, PINK1, and DJ-1 cause pure phenotypes usually characterized by levodopa-responsive Parkinson's disease.
Suzanne Lesage, Graziella Mangone, Christelle Tesson, Hélène Bertrand, Mustapha Benmahdjoub, Selma Kesraoui, Mohamed Arezki, Andrew Singleton, Jean-Christophe Corvol, Alexis Brice   +9 more
doaj   +1 more source

New insights into atypical parkinsonism [PDF]

Current Opinion in Neurology, 2011
Atypical parkinsonian disorders (APDs) comprise a heterogenous group of disorders including multiple system atrophy (MSA), dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Based on literature published in 2010, we here review recent advances in the APD field.Genome-wide association studies have ...
Gregor K, Wenning, Florian, Krismer, Werner, Poewe   +2 more
openaire   +2 more sources

Atypical parkinsonian syndromes in French Guiana: Similarities and differences with Caribbean variants

Journal of Parkinson’s Disease
Background Atypical parkinsonian syndromes are highly prevalent in the French West Indies (FWI), making up 70% of degenerative parkinsonisms and including “Caribbean Atypical Parkinsonism”. Environmental neurotoxins from Annonaceae plants are implicated.
Amina Nasri, Hugo Chaumont, Souraya Arnaud, Benoit Tressieres, Mamadou Sow, Angéla Lackmy, Régine Edragas, Mathieu Nacher, Bertrand de Toffol, Emmanuel Roze, Annie Lannuzel   +10 more
doaj   +1 more source

Sleep Disorders in Atypical Parkinsonism [PDF]

Movement Disorders Clinical Practice, 2014
AbstractSleep disorders are commonly observed in atypical parkinsonism, with particular disorders occurring more frequently in specific parkinsonian disorders. Multiple system atrophy (MSA) is a synucleinopathy often associated with nocturnal stridor, which is a serious, but treatable, condition highly specific to MSA.
Sabra M, Abbott, Aleksandar, Videnovic
openaire   +2 more sources

Effectiveness of an Inpatient Movement Disorders Program for Patients with Atypical Parkinsonism

Parkinson's Disease, 2012
This paper investigated the effectiveness of an inpatient movement disorders program for patients with atypical parkinsonism, who typically respond poorly to pharmacologic intervention and are challenging to rehabilitate as outpatients.
Anna D. Hohler, Jyeming M. Tsao, Douglas I. Katz, T. Joy DiPiero, Christina L. Hehl, Alissa Leonard, Valerie Allen, Maura Gardner, Heidi Phenix, Marie Saint-Hilaire, Terry Ellis   +10 more
doaj   +1 more source

Development and validation of the automated imaging differentiation in parkinsonism (AID-P): a multicentre machine learning study

The Lancet: Digital Health, 2019
Summary: Background: Development of valid, non-invasive biomarkers for parkinsonian syndromes is crucially needed. We aimed to assess whether non-invasive diffusion-weighted MRI can distinguish between parkinsonian syndromes using an automated imaging ...
Derek B Archer, PhD, Justin T Bricker, MS, Winston T Chu, BS, Roxana G Burciu, PhD, Johanna L McCracken, BS, Song Lai, ProfPhD, Stephen A Coombes, PhD, Ruogu Fang, PhD, Angelos Barmpoutis, PhD, Daniel M Corcos, PhD, Ajay S Kurani, PhD, Trina Mitchell, MS, Mieniecia L Black, MPH, Ellen Herschel, BS, Tanya Simuni, ProfMD, Todd B Parrish, ProfPhD, Cynthia Comella, ProfMD, Tao Xie, MD, Klaus Seppi, ProfMD, Nicolaas I Bohnen, ProfMD, Martijn LTM Müller, PhD, Roger L Albin, ProfMD, Florian Krismer, MD, Guangwei Du, MD, Mechelle M Lewis, PhD, Xuemei Huang, ProfMD, Hong Li, PhD, Ofer Pasternak, PhD, Nikolaus R McFarland, MD, Michael S Okun, ProfMD, David E Vaillancourt, ProfPhD   +30 more
doaj   +1 more source

Inflammation biomarker discovery in Parkinson's disease and atypical parkinsonisms [PDF]

BMC Neurology, 2019
Abstract Background: Parkinson’s disease (PD) and atypical parkinsonisms (APD) have overlapping symptoms challenging an early diagnosis. Diagnostic accuracy is important because PD and APD have different prognosis and response to treatment. We aimed to identify diagnostic inflammatory biomarkers of PD and APD in cerebrospinal fluid (CSF) using ...
Anna Santaella, H. Bea Kuiperij, Anouke van Rumund, Rianne A. J. Esselink, Alain J. van Gool, Bastiaan R. Bloem, Marcel M. Verbeek   +6 more
openaire   +4 more sources