Results 71 to 80 of about 173,798 (150)

Prion protein in the cerebrospinal fluid of healthy and naturally scrapie-affected sheep [PDF]

, 2006
The aim of this study was to characterize the cerebrospinal fluid (CSF) prion protein (PrP) of healthy and naturally scrapie-affected sheep. The soluble form of CSF PrPC immunoblotted with an anti-octarepeat and an anti-C terminus mAb showed two isoforms
Vé Ronique Gayrard, Moudjou, Mohammed, Gayrard-Troy, Véronique, V., Pierre-Louis Toutain, Mohammed Moudjou, Chantal Imbs, Viguié, Catherine, Toutain, Pierre-Louis, Imbs, Chantal, Moudjou, Mohammed, M., Catherine Viguié, Nicole Picard-Hagen, Picard-Hagen, Nicole, Gayrard, Véronique   +13 more
core   +1 more source

Species barrier as molecular basis for adaptation of synthetic prions with N‐terminally truncated PrP

The FEBS Journal, Volume 291, Issue 22, Page 5051-5076, November 2024.
Recombinant prion protein (PrP) assemblies from different primary mammalian structures can transmit and exhibit divergent adaptation processes and strain properties over passaging in transgenic mice expressing hamster PrP, mimicking the genuine evolutionary properties of prions across species barriers.
Human Rezaei, Davy Martin, Laetitia Herzog, Fabienne Reine, Alba Marín Moreno, Mohammed Moudjou, Naima Aron, Angélique Igel, Hannah Klute, Stella Youssafi, Jean‐Baptiste Moog, Pierre Sibille, Olivier Andréoletti, Joan Torrent, Vincent Béringue   +14 more
wiley   +1 more source

Prions in Milk from Ewes Incubating Natural Scrapie [PDF]

, 2008
Since prion infectivity had never been reported in milk, dairy products originating from transmissible spongiform encephalopathy (TSE)-affected ruminant flocks currently enter unrestricted into the animal and human food chain.
Bergonier Dominique, Fabien Corbière, Lacroux, Caroline, Cassard Hervé, Grassi, Jacques, Andréoletti Olivier, Torffin Moldal, Sylvie L. Benestad, Schelcher, Francois, F., Lugan, Séverine, S., Costes, Pierrette, Benestad Sylvie L., Simmons Hugh, Sylvie L Benestad, Nathalie Morel, Lantier, Frédéric, F., Simon Stéphanie, Lacroux Caroline, Weisbecker, Jean Louis, J. L., Benestad, Sylvie, Hervé Cassard, Bergonier, Dominique, Schelcher, François, Weisbecker, Jean-Louis, Morel, Nathalie, Weisbecker Jean-Louis, Lantier Frederic, Moldal, Torffin, François Schelcher, Stéphanie Simon, Simmons, Hugh, Dominique Bergonier, Morell, Nathalie, Jacques Grassi, Olivier Andréoletti, Schelcher François, Cécile Feraudet-Tarisse, Andréoletti, Olivier, Pierrette Costes, Cassard, Hervé, H., Corbière Fabien, Caroline Lacroux, Maillet, Séverinne, Mathey, Jacinthe, Jean-Louis Weisbecker, Mathey Jacinthe, Hugh Simmons, Cassard, Hervé, Corbière, Fabien, Féraudet-Tarisse, Cécile, Jacinthe Mathey, Feraudet-Tarisse Cécile, Frederic Lantier, Simon, Stéphanie, Séverine Lugan, Séverine Maillet, Morel Nathalie, Costes Pierrette, Costes, Pierrette, P., Lantier, Frédéric, Grassi Jacques, Benestad, Sylvie L, Lugan Séverine, Maillet, Séverine, Moldal Torffin, Lugan, Sévérine, Féraudet, Cécile, Lacroux, Caroline, C., Maillet Séverine   +68 more
core   +2 more sources

A new method for the Characterization of Strain-Specific Conformational Stability of Protease-Sensitive and Protease Resistant PrPSc [PDF]

, 2010
Although proteinacious in nature, prions exist as strains with specific self-perpetuating biological properties. Prion strains are thought to be associated with different conformers of PrPSc, a disease-associated isoform of the host-encoded cellular ...
Gabriele Vaccari, Laura Pirisinu, Marcon Stefano, Fazzi, P., Pirisinu Laura, Michele Di Bari, Nonno Romolo, Bari, M., Di, Marcon, S., Langeveld Jan, Paola Fazzi, Cardone, F., Vaccari Gabriele, Vaccari, G., Langeveld, J.P.M., Galeno Roberta, Roberta Galeno, Pirisinu, L., Esposito Elena, Fazzi Paola, Jan Langeveld, Nonno, R., Umberto Agrimi, D'Agostino, C., Elena Esposito, Stefano Marcon, Esposito, E., Claudia D'Agostino, Agrimi Umberto, Agrimi, U., Agostino, C., D', Di Bari, M., D'Agostino Claudia, Romolo Nonno, Di Bari Michele   +34 more
core   +2 more sources

Characterization of the prion protein in relation to normal cellular function and in disease [PDF]

, 2012
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of rare and fatal neurodegenerative disorders that can affect both human and animals.
Wik, Lotta
core   +1 more source

Review: A review on classical and atypical scrapie in caprine: Prion protein gene polymorphisms and their role in the disease

Animal, 2016
Scrapie is a naturally occurring transmissible spongiform encephalopathy in sheep and goat. It has been known for ~250 years and is characterised by the accumulation of an abnormal isoform of a host-encoded prion protein that leads to progressive ...
L. Curcio, C. Sebastiani, P. Di Lorenzo, E. Lasagna, M. Biagetti   +4 more
doaj   +1 more source

Evaluation of the application of Slovenia to be recognised as having a negligible risk of classical scrapie

EFSA Journal, Volume 22, Issue 10, October 2024.
Abstract Slovenia submitted a request to the European Commission to be recognised as a Member State with negligible risk of classical scrapie. EFSA has been asked to assess if Slovenia has demonstrated that, between 2016 and 2022, a sufficient number of ovine and caprine animals over 18 months old, representative of those slaughtered, culled or found ...
European Food Safety Authority (EFSA), Giulio Di Piazza, Giuseppe Ru, Marion Simmons, Barbara Lanfranchi, Angel Ortiz‐Peláez   +5 more
wiley   +1 more source

Classic Scrapie in Sheep with the ARR/ARR Prion Genotype in Germany and France

Emerging Infectious Diseases, 2007
In the past, natural scrapie and bovine spongiform encephalopathy (BSE) infections have essentially not been diagnosed in sheep homozygous for the A136R154R171 haplotype of the prion protein.
Martin H. Groschup, Caroline Lacroux, Anne Buschmann, Gesine Lühken, Jacinthe Mathey, Martin Eiden, Séverine Lugan, Christine Hoffmann, Juan Carlos Espinosa, Thierry G.M. Baron, Juan Maria Torres, Georg Erhardt, Olivier Andreoletti   +12 more
doaj   +1 more source

The complexity of extracellular vesicles: Bridging the gap between cellular communication and neuropathology

Journal of Neurochemistry, Volume 168, Issue 9, Page 2391-2422, September 2024.
Extracellular vesicles are ubiquitous to all cells, but their role in biology and pathology is multifaceted. In this report, we review the roles that extracellular vesicles can play in biological processes and cellular dysfunction and pathobiology, particularly neurodegenerative diseases.
Stephanie Tam, Darcy Wear, Christopher D. Morrone, Wai Haung Yu   +3 more
wiley   +1 more source

BSE risk posed by ruminant collagen and gelatine derived from bones

EFSA Journal, Volume 22, Issue 7, July 2024.
Abstract The European Commission requested an estimation of the BSE risk (C‐, L‐ and H‐BSE) from gelatine and collagen derived from ovine, caprine or bovine bones, and produced in accordance with Regulation (EC) No 853/2004, or Regulation (EC) No 1069/2009 and its implementing Regulation (EU) No 142/2011. A quantitative risk assessment was developed to
EFSA Panel on Biological Hazards (BIOHAZ), Konstantinos Koutsoumanis, Ana Allende, Declan Bolton, Sara Bover‐Cid, Marianne Chemaly, Alessandra De Cesare, Lieve Herman, Friederike Hilbert, Roland Lindqvist, Maarten Nauta, Romolo Nonno, Luisa Peixe, Giuseppe Ru, Marion Simmons, Panagiotis Skandamis, Elisabetta Suffredini, Amie Adkin, Olivier Andreoletti, John Griffin, Barbara Lanfranchi, Angel Ortiz‐Pelaez, Avelino Alvarez Ordonez   +22 more
wiley   +1 more source