Results 41 to 50 of about 8,070 (210)
Frontiers in Cellular and Infection Microbiology, 2021 Auranofin, a reprofiled FDA-approved drug originally designed to treat rheumatoid arthritis, has emerged as a promising anti-parasitic drug. It induces the accumulation of reactive oxygen species (ROS) in parasites, including Toxoplasma gondii.
Christopher I. Ma +10 more
doaj +1 more source
Antibiotics, 2020 Streptococcal toxic shock-like syndrome (STSLS) likely occurs when an individual is infected with the Streptococcus suis (S. suis) epidemic strain and is characterized by a cytokine storm, multiple organ dysfunction syndrome (MODS) and a high incidence ...
Hao Lu +10 more
doaj +1 more source
Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia. [PDF]
, 2014 Inherited deficiency in the mitochondrial protein frataxin (FXN) causes the rare disease Friedreich's ataxia (FA), for which there is no successful treatment. We identified a redox deficiency in FA cells and used this to model the disease.
Al-Mahdawi +78 more
core +1 more source
Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni [PDF]
, 2015 Schistosomiasis, one of the world's greatest neglected tropical diseases, is responsible for over 280,000 human deaths per annum. Praziquantel, developed in the 1970s, has high efficacy, excellent tolerability, few and transient side effects, simple ...
Altamura, Sergio +5 more
core +3 more sources
Efficacy of auranofin as an inhibitor of desmoid progression
Scientific Reports, 2022 Anticancer drugs and molecular targeted therapies are used for refractory desmoid-type fibromatosis (DF), but occasionally cause severe side effects. The purpose of this study was to identify an effective drug with fewer side effects against DF by drug ...
Kan Ito +12 more
doaj +1 more source
Auranofin coated catheters inhibit bacterial and fungal biofilms in a murine subcutaneous model
Frontiers in Cellular and Infection Microbiology, 2023 Microbe entry through catheter ports can lead to biofilm accumulation and complications from catheter-related bloodstream infection and ultimately require antimicrobial treatment and catheter replacement.
LewisOscar Felix +7 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
AntioxidantsGlioblastoma (GBM) is an incurable primary brain cancer characterized by increased reactive oxygen species (ROS) production. The redox-sensitive tumor suppressor gene TP53, wild-type (wt) for 70% of patients, regulates redox homeostasis.
Fatemeh Jamali +5 more
doaj +1 more source
Cyclic Voltammetry of Auranofin [PDF]
Metal-Based Drugs, 1999 The oxidative behavior of Auranofin, 2,3,4,6‐tetra‐O‐acetyl‐1‐thio‐β ‐D‐glucopyranosato‐ S(triethylphosphine)gold(I), was investigated by using cyclic voltammetry (CV) in 0.1 M Bu4NPF6/CH2Cl2 and 0.1 M Bu4NPF4/CH2Cl2 solutions using Pt working and auxiliary electrodes and a Ag/AgCI reference.
Mohamed, Ahmed A. +2 more
openaire +2 more sources
Mass spectrometry as a powerful tool to study therapeutic metallodrugs speciation mechanisms: current frontiers and perspectives [PDF]
, 2017 Metal-based compounds form a promising class of therapeutic agents, whose mechanisms of action still need to be elucidated, and that are in general prone to undergo extensive speciation in physiological environment.
Casini, Angela, Wenzel, Margot
core +2 more sources