Results 71 to 80 of about 8,070 (210)

Therapeutic imprinting of the immune system: towards a remission of AIDS in primates? [PDF]

, 2012
Our inability to cure HIV/AIDS is related to the ability of the virus to establish reservoirs during treatment. In order to develop new strategies, it is certainly essential that a suitable animal model be implemented. In the recent work of Shytaj et al.,
Andrea Savarino, Enrico Garaci
core   +1 more source

Reversal Potential of Multidrug Antibiotic Resistance in Cutibacterium acnes by Ethanol Extracts of Rhubarb

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
1. Ethanol extract of Rhubarb effectively reversed regular clinical antibiotic resistance, and was confirmed by growth curves and oxidative markers. 2. Reversal effects were observed with erythromycin (1000‐fold), clindamycin (250‐fold) and tetracycline (2–4‐fold). 3.
Doudou Yang, Yu Cui, Sen Zhu, Ruoliang Wang, Haijun Xu, Guanjie Zhao, Dandan Zhang, Yinku Liang   +7 more
wiley   +1 more source

Gold(I) ion and the phosphine ligand are necessary for the anti-Toxoplasma gondii activity of auranofin

Microbiology Spectrum
Auranofin, an FDA-approved drug for rheumatoid arthritis, has emerged as a promising antiparasitic medication in recent years. The gold(I) ion in auranofin is postulated to be responsible for its antiparasitic activity.
C. I. Ma, J. A. Tirtorahardjo, S. S. Schweizer, J. Zhang, Z. Fang, L. Xing, M. Xu, D. A. Herman, M. T. Kleinman, B. S. McCullough, A. M. Barrios, R. M. Andrade   +11 more
doaj   +1 more source

Emerging role of endosomal toll-like receptors in rheumatoid arthritis [PDF]

, 2014
Toll-like receptors (TLRs) and their downstream signaling pathways have been comprehensively characterized in innate immunity. In addition to this function, these receptors have also been suggested to be involved in the pathogenesis of many autoimmune ...
Chamberlain, Giselle, Sacre, Sandra, Thwaites, Ryan   +2 more
core   +2 more sources

Amino Acid‐Based Cinnamoyl Thiourea Ligands and Their Copper(II) Complexes: Synthesis, in Silico, and Antibacterial Evaluation

ChemistrySelect, Volume 10, Issue 47, December 15, 2025.
Molecular docking and ADME analysis were exploited to identify promising bioactive compounds, followed by the design and synthesis of targeted compounds. The synthesized molecules were subjected to biological evaluation, demonstrating their potential antimicrobial activity.
Brandon Sanday Mominn, Maya Asyikin Mohamad Arif   +1 more
wiley   +1 more source

Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes

Nature Communications, 2023
UBA1 is the primary E1 ubiquitin-activating enzyme responsible for generation of activated ubiquitin required for ubiquitination, a process that regulates stability and function of numerous proteins.
Wenjing Yan, Yongwang Zhong, Xin Hu, Tuan Xu, Yinghua Zhang, Stephen Kales, Yanyan Qu, Daniel C. Talley, Bolormaa Baljinnyam, Christopher A. LeClair, Anton Simeonov, Brian M. Polster, Ruili Huang, Yihong Ye, Ganesha Rai, Mark J. Henderson, Dingyin Tao, Shengyun Fang   +17 more
doaj   +1 more source

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, Volume 19, Issue 11, Page 3003-3022, November 2025.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays [PDF]

, 2018
The protozoan parasite Leishmania causes leishmaniasis; a spectrum of diseases of which there are an estimated 1 million new cases each year. Current treatments are toxic, expensive, difficult to administer, and resistance to them is emerging.
Berry, SL, Hameed, H, Horrocks, P, Maciej-Hulme, ML, Price, HP, Saif Abou-Akkada, S, Thomason, A   +6 more
core   +7 more sources

Glabridin‐Gold(I) Complex as a Novel Immunomodulatory Agent Targeting TrxR and MAPK Pathways for Synergistic Enhancement of Antitumor Immunity

Advanced Science, Volume 12, Issue 41, November 6, 2025.
Complex 6d could promote tumor immunogenicity by targeting thioredoxin reductase (TrxR) and remodel immunosuppressive microenvironment by the mitogen‐activated protein kinase (MAPK) pathway inhibition simultaneously. This study provides a novel approach to develop metal immunomodulatory agents by designing gold complexes incorporating natural products,
Zhaoran Wang, Meiyu Wang, Qiong Chen, Mengshi Wang, Fuwei Li, Lin Lv, Zhenfan Wen, Zhongren Xu, Yixia Yang, Chunyang Bi, Wukun Liu   +10 more
wiley   +1 more source

Synergistic Microbicidal Effect of Auranofin and Antibiotics Against Planktonic and Biofilm-Encased S. aureus and E. faecalis

Frontiers in Microbiology, 2019
Methicillin-resistant/susceptible Staphylococcus aureus (MRSA/MSSA) and Enterococcus faecalis strains are often found in community- and hospital-acquired infections.
Pengfei She, Linying Zhou, Shijia Li, Yiqing Liu, Lanlan Xu, Lihua Chen, Zhen Luo, Yong Wu   +7 more
doaj   +1 more source