Results 81 to 90 of about 8,070 (210)

Chemical behavior and in vitro activity of mixed phosphine gold(I)compounds on melanoma cell lines. [PDF]

, 2008
7partially_openCARUSO F; PETTINARI C; PADUANO F; VILLA R; MARCHETTI F; E. MONTI; ROSSI MCaruso, F; Pettinari, C; Paduano, F; Villa, R; Marchetti, F; Monti, ELENA CATERINA; Rossi ...
CARUSO F., MARCHETTI F., MONTI E., PADUANO F., PETTINARI C., ROSSI M., VILLA R.   +6 more
core   +1 more source

Protein Kinase C Family: Structures, Biological Functions, Diseases, and Pharmaceutical Interventions

MedComm, Volume 6, Issue 11, November 2025.
Ligand–receptor binding activates PLC, which hydrolyzes the membrane lipid PIP2, generating the second messenger's IP3 and DAG. IP3 binding to ER receptors causes Ca2⁺ release. Subsequently, PKC are recruited to the membrane, which induces a conformational change in PKC, leading to the full enzymatic activation.
Yongqi Li, Yuhan Jiang, Zhengxi Hu, Shenglan Yang, Longyin Li, Chaohu Xiong, Ya Gao, Weiguang Sun, Yonghui Zhang   +8 more
wiley   +1 more source

Auranofin as a Novel Anticancer Drug for Anaplastic Thyroid Cancer

Pharmaceuticals
Background/Objectives: Anaplastic thyroid cancer (ATC) is an aggressive and rare cancer with a poor prognosis, and traditional therapies have limited efficacy.
Seung-Chan An, Hak Hoon Jun, Kyeong Mi Kim, Issac Kim, Sujin Choi, Hyunjeong Yeo, Soonchul Lee, Hyun-Ju An   +7 more
doaj   +1 more source

Mechanistic insights into gold organometallic compounds and their biomedical application [Correction] [PDF]

, 2017
The application of gold in medicine can be traced back several thousand years and Au(i) compounds have been used in the treatment of rheumatoid arthritis since the last century.
Casini, Angela, Jürgens, Sophie
core   +3 more sources

Health related utility measurement in rheumatology: an introduction [PDF]

, 1993
Utility measures of health-related quality of life are preference values that patients attach to their overall health status. In clinical trials, utility measures summarize both positive and negative effects of an intervention into one single value ...
Bakker, C.H. (Carla), Bennett, K. (Kathleen), Doorslaer, E.K.A. (Eddy) van, Linden, S. van der, Rutten-van Mölken, M.P.M.H. (Maureen)   +4 more
core   +1 more source

Mannose‐Inspired Mesoionic Carbenes: Building Antitumor Palladium(II) Allyl Complexes

European Journal of Inorganic Chemistry, Volume 28, Issue 29, October 16, 2025.
Mannose‐inspired mesoionic carbenes: Building antitumor palladium(II) allyl complexes. A series of palladium(II) complexes bearing mannose‐conjugated mesoionic carbenes has been synthesized and fully characterized. Several of these compounds exhibit potent and selective antiproliferative activity against cisplatin‐resistant ovarian and colon cancer ...
Giovanni Tonon, Martina Scianna, Isabella Caligiuri, Flavio Rizzolio, Fabiano Visentin, Thomas Scattolin   +5 more
wiley   +1 more source

Identification of New Drug Candidates Against \u3cem\u3eBorrelia burgdorferi\u3c/em\u3e Using High-Throughput Screening [PDF]

, 2016
Lyme disease is the most common zoonotic bacterial disease in North America. It is estimated that .300,000 cases per annum are reported in USA alone. A total of 10%–20% of patients who have been treated with antibiotic therapy report the recrudescence of
Babar, Mustafeez Mujtaba, Inayathullah, Mohammed, Kim, K. M., Parekh, Mansi B., Pothineni, Venkata Raveendra, Rajadas, Jayakumar, Samineni, A. V., Solow-Cordero, David, Tayebi, Lobat, Wagh, Dhananjay   +9 more
core   +3 more sources

Free Radicals in Health and Disease

MedComm, Volume 6, Issue 10, October 2025.
Free radicals have dual roles that can either selectively create oxidative damages to transformed cells in treating proliferative diseases such as cancers and some dermatological disorders or boost the antioxidant system in treating degenerative diseases such as neurodegenerative disorder, joint degeneration, and metabolic conditions.
Xiaofeng Dai, Zizheng Huang, Ruohan Lyu
wiley   +1 more source

Auranofin amplifies schisandrin A-induced apoptosis through ROS generation and inhibiting the PI3K/Akt pathway in hepatocellular carcinoma

Asian Pacific Journal of Tropical Biomedicine
Objective: To investigate the synergistic effects of auranofm and schisandrin A (SA) on cell proliferation inhibition and apoptosis induction in human hepatocellular carcinoma Hep3B cells.
Hyun Hwangbo, Seon Yeong Ji, Min Yeong Kim, Su Hyun Hong, Sung Ok Kim, Gi-Young Kim, Yung Hyun Choi   +6 more
doaj   +1 more source

Cycloaurated GoId (III) complexes- Possible alternatives to cisplatin? [PDF]

, 2009
The serendipitous discovery of the anti-tumour activity of cisplatin [cis-PtCI₂(NH₃)₂] in 1969 has led to increased interest in the development of new metal-based anti-cancer drugs.
Henderson, William, Kilpin, Kelly Joan
core   +1 more source