Results 151 to 160 of about 513,015 (296)
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, EarlyView.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources
A microscopically assisted limited colectomy mouse model of early colon cancer
Animal Models and Experimental Medicine, EarlyView.Establishment, surgery, and evaluation process of a microscope‐assisted limited colon resection mouse model for early‐stage colon cancer. Abstract Background Currently, there is a lack of an adequate rodent model for investigating surgical techniques and comprehensive treatment options for patients with colorectal cancer (CRC).
Yu Han +3 more
wiley +1 more source
Bent N‐Heterocyclic Allenes From a Well‐Defined Titanium Vinylidene Complex
Angewandte Chemie, EarlyView.The syntheses and the structures of N‐heterocyclic allenes are reported. Allenes bearing fluorenylidene capping groups show markedly bent C═C═C units, a carbene‐like reactivity, and they can act as potent C‐donor ligands for metal complexes. ABSTRACT Allenes typically display a linear geometry. A notable exception occurs in allenes bearing two electron‐
Bastiaan Kooij +4 more
wiley +2 more sources
Authenticity of materials and foreign language teaching
Pandaemonium Germanicum: Revista de Estudos Germanísticos, 2017 This article aims to revisit the discussion about the concept of authenticity in the teaching of foreign languages by authors of great relevance in German and English, as well as in Brazil, emphasizing the role of authenticity of materials.
Mariana Kuntz de Andrade e Silva
doaj
Animal Models and Experimental Medicine, EarlyView.Adenostemma lavenia, a traditionally used medicinal plant, has been employed to manage pain, inflammation, and circulatory issues. This study investigates the analgesic, anti‐inflammatory, and thrombolytic potentials of the acetone extract of A. lavenia leaves (AEAL) using in vivo, in vitro, and in silico methods.
Nusrat Jahan Moon +10 more
wiley +1 more source
Discovery of a Plant Pictet–Spenglerase With R‐Stereoselectivity
Angewandte Chemie, EarlyView.Strictosidine synthases (STRs) are plant Pictet–Spenglerases catalyzing the coupling of a secoiridoid with tryptamine. All previously characterized strictosidine synthases are strictly S‐selective. Here, we report the discovery of Epi‐STR, an R‐selective STR ortholog from the medicinal plant Pogonopus speciosus.
Clara Morweiser +3 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Cyclic diaryliodonium salts engage aryl Grignard reagents to trigger a self‐propagating aryne–arylation cycle. Transient cyclic triaryliodanes serve as aryne precursors and dynamic aryl reservoirs, delivering iodine‐capped teraryls with predominant meta‐selectivity. The preserved C─I bond enables outward π‐extension or inward recyclization.
Daichi Ikeshita +2 more
wiley +2 more sources
A Revised Model for Muscarine Biosynthesis Involving Lysine Trimethylation
Angewandte Chemie, EarlyView.The fatal mushroom toxin l‐(+)‐muscarine is one of the most prominent natural products. We elucidated its biosynthetic origin in the sweating mushroom Collybia rivulosa based on incorporation of stable isotope‐labeled compounds and extensive mass spectrometric analyses.
Sebastian Dörner +4 more
wiley +2 more sources