Results 121 to 130 of about 219,094 (347)

Therapeutic Potential of Lipid Nanoparticle‐Encapsulated CD19‐Targeting mRNAs in Lupus and Rheumatoid Arthritis

Advanced Science, EarlyView.
This study develops lipid nanoparticle‐encapsulated mRNA‐encoding antibodies (mRNab‐LNPs) targeting CD19, demonstrating robust anti‐CD19 antibody production in vivo. Intramuscular injection of mRNab‐LNPs reduces CD19+ B and plasma cells in lupus and rheumatoid arthritis mice, significantly alleviating histopathological changes and tissue injuries of ...
Chipeng Guo, Yingsen Tang, Ling Zeng, Xiaomei You, Siweier Luo, Yufei Du, Le Wang, Liangchun Wang, Jianchuan Wang, Jinjin Chen, Yiming Zhou   +10 more
wiley   +1 more source

Clinical Significance and Diagnostic Value of Survivin Autoantibody in Non-small Cell Lung Cancer Patients

Chinese Journal of Lung Cancer, 2010
Background and objective Lung cancer is one of the most common cancers worldwide and causes more deaths per year than other cancers. Autoantibody was one hotspot in tumor marker research.
Li MA, Wentao YUE, Lina ZHANG, Yue WANG, Chunyan ZHANG, Xuehui YAN   +5 more
doaj  

A multi-etiology model of systemic degeneration in schizophrenia [PDF]

arXiv, 2008
We discuss the possibility of multiple underlying etiologies of the condition currently labeled as schizophrenia. We support this hypothesis with a theoretical model of the prefrontal-limbic system. We show how the dynamical behavior of this model depends on an entire set of physiological parameters, representing synaptic strengths, vulnerability to ...
arxiv  

A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort [PDF]

, 2010
<p><b>Objectives</b> The aim of this study was to confirm the influence of TNFSF4 polymorphisms on systemic sclerosis (SSc) susceptibility and phenotypic features.</p> <p><b>Methods</b> A total of 8 European ...
A E Voskuyl, A Fernández-Nebro, A Herrick, A J Schuerwegh, A Kreuter, A Nordin, A Pros, B A Lie, B P Koeleman, B Rueda, C Denton, C Fonseca, C P Simeon, C Tolosa, E De Langhe, E Vicente-Rabaneda, F De Keyser, F Houssiau, F J García-Hernández, G Espinosa, G Riemekasten, H Manku, I Castellví, I Gómez-Gracia, J A Román-Ivorra, J M van Laar, J Martín, J Worthington, JCA Broen, K Claes, L Beretta, L Bossini-Castillo, L Padykov, L Rodríguez, M A González-Gay, M C Vonk, M F González-Escribano, M Gallego, M M Chee, M T Camps, M V Egurbide, MJ Gough, MJH Coenen, N Hunzelmann, N Navarrete, N Ortego-Centeno, P Airó, P Carreira, P García de la Peña, P Gourh, P Shiels, R Hesselstrand, R Madhok, R Scorza, R Westhovens, T Witte, TRDJ Radstake, V Follonosa, V Smith, Ø Palm   +59 more
core   +4 more sources

Identification of the immunodominant epitope region in phospholipase A2 receptor-mediating autoantibody binding in idiopathic membranous nephropathy.

Journal of the American Society of Nephrology, 2015
Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults. Recent clinical studies established that >70% of patients with idiopathic (also called primary) MN (IMN) possess circulating autoantibodies targeting the M-type phospholipase ...
Liyo Kao, Vinson Lam, M. Waldman, R. Glassock, Quansheng Zhu   +4 more
semanticscholar   +1 more source

Prognostic significance of six autoantibodies in esophageal squamous cell carcinoma: A prospective multi‐institutional study

Annals of Gastroenterological Surgery, EarlyView.
The six autoantibodies (Sui1, p62, RalA, p53, NY‐ESO‐1 and c‐myc) positive group had poor prognosis compared to autoantibody negative group. A panel of autoantibodies against a tumor associated antigen in esophageal cancer patients had an additive effect with SCC‐Ag to detect esophageal SCC even in early stage.
Fumiaki Shiratori, Naoto Fujiwara, Yasuaki Nakajima, Koji Otsuka, Masahiko Murakami, Satoru Matsuda, Hirofumi Kawakubo, Keita Takahashi, Yuichiro Tanishima, Daiji Oka, Shunichi Ito, Kosuke Narumiya, Osamu Aramaki, Tadatoshi Takayama, Takashi Suzuki, Satoshi Yajima, Hideaki Shimada   +16 more
wiley   +1 more source

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity

Frontiers in Pediatrics, 2018
The illness ME/CFS has been repeatedly tied to infectious agents such as Epstein Barr Virus. Expanding research on the human microbiome now allows ME/CFS-associated pathogens to be studied as interacting members of human microbiome communities.
Amy Proal, Trevor Marshall
doaj   +1 more source

A patient with anti-NXP2-positive dermatomyositis and syphilis [PDF]

, 2020
Dermatomyositis is an auto-immune inflammatory myopathy that primarily affects the skin and muscle and can be triggered by exposure to various environmental factors.
Bovenberg, Maria Sarah Sophie, Brassard, Alain, Hai, Josephine, Kiuru, Maija, Nguyen, Mimi, Tartar, Danielle, Wilken, Reason   +6 more
core  

Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers : implications for autoimmunity in rheumatoid arthritis [PDF]

, 2015
Introduction: Smoking is a well-established risk factor for rheumatoid arthritis (RA), and it has been proposed that smoking-induced citrullination renders autoantigens immunogenic.
Bracke, Ken, Brusselle, Guy, Correia, Raquel ESM, Fischer, Roman, Kessler, Benedikt M, Lugli, Elena B, Lundberg, Karin, Montgomery, Anna B, Venables, Patrick J   +8 more
core   +2 more sources

Incompatible blood transfusion: Challenging yet lifesaving in the management of acute severe autoimmune hemolytic anemia

Asian Journal of Transfusion Science, 2014
Background and Aim: Autoimmune hemolytic anemia (AIHA) is characterized by the production of autoantibodies directed against red cell antigens. Most patients of AIHA arrive in the emergency or out-patient department (OPD) with severe anemia requiring ...
Sudipta Sekhar Das, Rafiq Uz Zaman, Mohammad Safi   +2 more
doaj   +1 more source