Biomedicines, 2022 The aim of this study was to explore the value of autoantibody to GNAS in the early detection of hepatocellular carcinoma (HCC). In a large-scale sample set of 912 participants (228 cases in each of HCC, liver cirrhosis (LC), chronic hepatitis B (CHB ...
Xiao Wang +7 more
doaj +1 more source
Frontiers in Immunology, 2022 Occupational exposure to inhaled crystalline silica dust (cSiO2) is linked to systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, and anti-neutrophil cytoplasmic autoantibody vasculitis.
Lanette Fee +6 more
doaj +1 more source
Annals of the Rheumatic Diseases, 2019 Objectives Idiopathic inflammatory myopathies (IIM) are a spectrum of rare autoimmune diseases characterised clinically by muscle weakness and heterogeneous systemic organ involvement.
S. Rothwell +32 more
semanticscholar +1 more source
Autoantibody Reversion: Changing Risk Categories in Multiple-Autoantibody–Positive Individuals
Diabetes Care, 2020 OBJECTIVE Most individuals with two or more islet autoantibodies progress to clinical type 1 diabetes. However, in some individuals, autoantibodies are subsequently lost.
Michelle So +4 more
semanticscholar +1 more source
Systemic translocation of Staphylococcus drives autoantibody production in HIV disease
Microbiome, 2019 Background Increased autoreactive antibodies have been reported in HIV disease; however, the mechanism accounting for autoantibody induction in HIV remains unknown.
Zhenwu Luo +21 more
doaj +1 more source
Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice. [PDF]
, 1993 We have generated transgenic mice that express the immunoglobulin (Ig)M heavy chain and kappa light chain genes coding for a human IgM rheumatoid factor (RF), Les.
Carson, DA +6 more
core +2 more sources
Expression-Based Genome-Wide Association Study Links Vitamin D-Binding Protein With Autoantigenicity in Type 1 Diabetes. [PDF]
, 2016 Type 1 diabetes (T1D) is caused by autoreactive T cells that recognize pancreatic islet antigens and destroy insulin-producing β-cells. This attack results from a breakdown in tolerance for self-antigens, which is controlled by ectopic antigen expression
Butte, Atul J +9 more
core +1 more source
Genome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus Erythematosus. [PDF]
PLoS ONE, 2015 Systemic lupus erythematosus (SLE) is characterized by the development of autoantibodies associated with specific clinical manifestations. Previous studies have shown an association between differential DNA methylation and SLE susceptibility, but have ...
Sharon A Chung +6 more
doaj +1 more source
Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis. [PDF]
, 2009 Background: Recent evidence suggests that distinction of subsets of rheumatoid arthritis (RA) depending on anticyclic citrullinated peptide antibody (anti-CCP) status may be helpful in distinguishing distinct aetiopathologies and in predicting the ...
Burmester, G.R. +7 more
core +1 more source
Autoantibody Development under Treatment with Immune-Checkpoint Inhibitors
Cancer immunology research, 2018 Ipilimumab induced autoantibodies in a fifth of melanoma patients. Patients who developed autoantibodies, especially thyroid autoantibodies, experienced more irAEs and had a survival and response benefit, suggesting that breaking of B-cell tolerance ...
E. C. de Moel +9 more
semanticscholar +1 more source