Results 41 to 50 of about 235,603 (337)

The Autoantibody Array Assay: A Novel Autoantibody Detection Method

Diagnostics, 2023
Systemic sclerosis (SSc) and dermatomyositis (DM) are autoimmune collagen diseases. Specific autoantibodies are known to be involved in their pathogeneses, each presenting with a different clinical manifestation.
Yuta Norimatsu, Kazuki Mitsuru Matsuda, Kei Yamaguchi, Chihiro Ono, Taishi Okumura, Emi Kogo, Hirohito Kotani, Teruyoshi Hisamoto, Ai Kuzumi, Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Naoki Goshima, Shinichi Sato, Ayumi Yoshizaki   +13 more
doaj   +1 more source

A Toll for lupus [PDF]

, 2005
Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
Anders HJ, H-J Anders, Stacey KJ
core   +1 more source

Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups

Annals of the Rheumatic Diseases, 2019
Objectives Idiopathic inflammatory myopathies (IIM) are a spectrum of rare autoimmune diseases characterised clinically by muscle weakness and heterogeneous systemic organ involvement.
S. Rothwell, H. Chinoy, J. Lamb, F. Miller, L. Rider, L. Wedderburn, N. McHugh, A. Mammen, Z. Betteridge, S. Tansley, J. Bowes, J. Vencovský, C. Deakin, K. Dankó, L. Vidya, A. Selva-O’Callaghan, L. Pachman, A. Reed, Ø. Molberg, O. Benveniste, P. Mathiesen, T. Radstake, A. Doria, J. D. De Bleecker, Annette Lee, M. Hanna, P. Machado, W. Ollier, P. Gregersen, L. Padyukov, T. O’Hanlon, R. Cooper, I. Lundberg   +32 more
semanticscholar   +1 more source

Autoreactive B cells recruited to lungs by silica exposure contribute to local autoantibody production in autoimmune-prone BXSB and B cell receptor transgenic mice

Frontiers in Immunology, 2022
Occupational exposure to inhaled crystalline silica dust (cSiO2) is linked to systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, and anti-neutrophil cytoplasmic autoantibody vasculitis.
Lanette Fee, Lanette Fee, Advika Kumar, Robert M. Tighe, Robert M. Tighe, Mary H. Foster, Mary H. Foster   +6 more
doaj   +1 more source

A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity [PDF]

, 2007
Rheumatoid arthritis (RA) is a chronic inflammatory disease with a heritability of 60%. Genetic contributions to RA are made by multiple genes, but only a few gene associations have yet been confirmed.
Alfredsson, L, Burkhardt, H, Holmdahl, Rikard,, Kallberg, H, Klareskog, L, Lindqvist, Anna-Karin,, Lund University., Olsson, Lina,, Padyukov, L   +8 more
core   +2 more sources

Early B cell tolerance defects in neuromyelitis optica favour anti-AQP4 autoantibody production.

Brain : a journal of neurology, 2019
Neuromyelitis optica spectrum disorders (NMOSD) constitute rare autoimmune disorders of the CNS that are primarily characterized by severe inflammation of the spinal cord and optic nerve. Approximately 75% of NMOSD patients harbour circulating pathogenic
E. Cotzomi, P. Stathopoulos, Casey S. Lee, A. Ritchie, J. Soltys, F. Delmotte, T. Oe, Joel Sng, Ruoyi Jiang, Anthony K Ma, J. V. Vander Heiden, S. Kleinstein, M. Levy, J. Bennett, E. Meffre, K. O’Connor   +15 more
semanticscholar   +1 more source

Autoantibody Development under Treatment with Immune-Checkpoint Inhibitors

Cancer immunology research, 2018
Ipilimumab induced autoantibodies in a fifth of melanoma patients. Patients who developed autoantibodies, especially thyroid autoantibodies, experienced more irAEs and had a survival and response benefit, suggesting that breaking of B-cell tolerance ...
E. C. de Moel, E. Rozeman, E. Kapiteijn, E. Verdegaal, A. Grummels, J. Bakker, T. Huizinga, J. Haanen, R. Toes, D. van der Woude   +9 more
semanticscholar   +1 more source

Baseline autoantibody profile in rheumatoid arthritis is associated with early treatment response but not long-term outcomes

Arthritis Research & Therapy, 2018
Background The autoantibody profile of seropositive rheumatoid arthritis (RA) is very diverse and consists of various isotypes and antibodies to multiple post-translational modifications. It is yet unknown whether this varying breadth of the autoantibody
Emma C. de Moel, Veerle F. A. M. Derksen, Gerrie Stoeken, Leendert A. Trouw, Holger Bang, Robbert J. Goekoop, Irene Speyer, Tom W. J. Huizinga, Cornelia F. Allaart, René E. M. Toes, Diane van der Woude   +10 more
doaj   +1 more source

Transient positivity of anti-tissue transglutaminase IgA autoantibody in febrile children: a case-control study

The Turkish Journal of Pediatrics, 2021
Background. Fever is a physiological response activated by integrative interactions between the neuronal and immune systems. The association of fever with the development of autoantibodies against various self-antigens is controversial.
Iraj Shahramian, Mehrdad Salahifar, Majid Reza Akbarizadeh, Mohammad Hasan Mohammadi, Ali Bazi   +4 more
doaj   +1 more source

DPVis: Visual Analytics with Hidden Markov Models for Disease Progression Pathways

, 2020
Clinical researchers use disease progression models to understand patient status and characterize progression patterns from longitudinal health records.
Anand, Vibha, Frohnert, Brigitte I, Ghosh, Soumya, Kwon, Bum Chul, Lundgren, Markus, Ng, Kenney, Severson, Kristen A, Sun, Zhaonan   +7 more
core   +1 more source