Annals of the Rheumatic Diseases, 2019 Objectives Idiopathic inflammatory myopathies (IIM) are a spectrum of rare autoimmune diseases characterised clinically by muscle weakness and heterogeneous systemic organ involvement.
S. Rothwell +32 more
semanticscholar +1 more source
Systemic translocation of Staphylococcus drives autoantibody production in HIV disease
Microbiome, 2019 Background Increased autoreactive antibodies have been reported in HIV disease; however, the mechanism accounting for autoantibody induction in HIV remains unknown.
Zhenwu Luo +21 more
doaj +1 more source
Expression-Based Genome-Wide Association Study Links Vitamin D-Binding Protein With Autoantigenicity in Type 1 Diabetes. [PDF]
, 2016 Type 1 diabetes (T1D) is caused by autoreactive T cells that recognize pancreatic islet antigens and destroy insulin-producing β-cells. This attack results from a breakdown in tolerance for self-antigens, which is controlled by ectopic antigen expression
Butte, Atul J +9 more
core +1 more source
Autoimmune thyroiditis in patients with sudden sensorineural hearing loss
Laryngoscope Investigative Otolaryngology, 2022 Objective This study aims to evaluate the association between autoimmune thyroiditis and Sudden Sensorineural Hearing Loss (SSNHL). Methods Hundred and five patients with SSNHL were enrolled.
Xiao‐Mei Sun +7 more
doaj +1 more source
Frontiers in Immunology, 2022 Occupational exposure to inhaled crystalline silica dust (cSiO2) is linked to systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, and anti-neutrophil cytoplasmic autoantibody vasculitis.
Lanette Fee +6 more
doaj +1 more source
Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis. [PDF]
, 2009 Background: Recent evidence suggests that distinction of subsets of rheumatoid arthritis (RA) depending on anticyclic citrullinated peptide antibody (anti-CCP) status may be helpful in distinguishing distinct aetiopathologies and in predicting the ...
Burmester, G.R. +7 more
core +1 more source
S100a9 Protects Male Lupus-Prone NZBWF1 Mice From Disease Development
Frontiers in Immunology, 2021 Systemic lupus erythematosus (SLE) is an autoimmune disorder disproportionally affecting women. A similar sex difference exists in the murine New Zealand Black/White hybrid model (NZBWF1) of SLE with all females, but only 30-40% of males, developing ...
Laura M. Davison +11 more
doaj +1 more source
Autoantibody Development under Treatment with Immune-Checkpoint Inhibitors
Cancer immunology research, 2018 Ipilimumab induced autoantibodies in a fifth of melanoma patients. Patients who developed autoantibodies, especially thyroid autoantibodies, experienced more irAEs and had a survival and response benefit, suggesting that breaking of B-cell tolerance ...
E. C. de Moel +9 more
semanticscholar +1 more source
Autoreactivity to malondialdehyde-modifications in rheumatoid arthritis is linked to disease activity and synovial pathogenesis [PDF]
J Autoimmun. 2017 Nov; 84:29-45, 2017 Oxidation-associated malondialdehyde (MDA) modification of proteins can generate immunogenic neo-epitopes that are recognized by autoantibodies. In health, IgM antibodies to MDA-adducts are part of the natural antibody pool, while elevated levels of IgG anti-MDA are associated with inflammatory conditions.
arxiv +1 more source
DPVis: Visual Analytics with Hidden Markov Models for Disease Progression Pathways
, 2020 Clinical researchers use disease progression models to understand patient status and characterize progression patterns from longitudinal health records.
Anand, Vibha +7 more
core +1 more source