Results 51 to 60 of about 219,094 (347)
Genome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus Erythematosus. [PDF]
PLoS ONE, 2015 Systemic lupus erythematosus (SLE) is characterized by the development of autoantibodies associated with specific clinical manifestations. Previous studies have shown an association between differential DNA methylation and SLE susceptibility, but have ...
Sharon A Chung +6 more
doaj +1 more source
Autoantibody recognition mechanisms of MUC1 [PDF]
, 2016 The most cost-effective blood-based, noninvasive molecular cancer biomarkers are based on p53 epitopes and MUC1 tandem repeats. Here we use dimensionally compressed bioinformatic fractal scaling analysis to compare the two distinct and comparable probes, which examine different sections of the autoantibody population, achieving combined sensitivities ...
arxiv +1 more source
Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus. [PDF]
, 2016 High titer, class-switched autoantibodies are a hallmark of systemic lupus erythematosus (SLE). Dysregulation of the interferon (IFN) pathway is observed in individuals with active SLE, although the association of specific autoantibodies with chemokine ...
Baechler, Emily C +10 more
core +2 more sources
Arthritis & Rheumatology, 2019 Systemic lupus erythematosus (SLE) is characterized by the production of antibodies against self antigens. However, the events underlying autoantibody formation in SLE remain unclear.
Elizabeth Ogunrinde +9 more
semanticscholar +1 more source
Arthritis Research & Therapy, 2018 Background The autoantibody profile of seropositive rheumatoid arthritis (RA) is very diverse and consists of various isotypes and antibodies to multiple post-translational modifications. It is yet unknown whether this varying breadth of the autoantibody
Emma C. de Moel +10 more
doaj +1 more source
OncoImmunology, 2021 Serum autoantibodies against tumor-associated antigen have important value in the early diagnosis of hepatocellular carcinoma (HCC), but the mechanism of autoantibody production is poorly understood.
Xiaojin Li +11 more
doaj +1 more source
Autoantibody recognition mechanisms of p53 epitopes [PDF]
, 2015 There is an urgent need for economical blood based, noninvasive molecular biomarkers to assist in the detection and diagnosis of cancers in a cost effective manner at an early stage, when curative interventions are still possible. Serum autoantibodies are attractive biomarkers for early cancer detection, but their development has been hindered by the ...
arxiv +1 more source
Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons [PDF]
Journal of Experimental Medicine Aug 2019, 216 (8) 1904-1924, 2019 Rheumatoid arthritis-associated joint pain is frequently observed independent of disease activity, suggesting unidentified pain mechanisms. We demonstrate that antibodies binding to cartilage, specific for collagen type II (CII) or cartilage oligomeric matrix protein (COMP), elicit mechanical hypersensitivity in mice, uncoupled from visual ...
arxiv +1 more source
, 2005 Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
Anders HJ, H-J Anders, Stacey KJ
core +1 more source
Clinical Chemistry, 2019 BACKGROUND The Islet Autoantibody Standardization Program (IASP) aims to improve the performance of immunoassays measuring type 1 diabetes (T1D)-associated autoantibodies and the concordance of results among laboratories.
V. Lampasona +6 more
semanticscholar +1 more source