Results 51 to 60 of about 235,603 (337)

A Link Between Plasma Microbial Translocation, Microbiome, and Autoantibody Development in First‐Degree Relatives of Systemic Lupus Erythematosus Patients

Arthritis & Rheumatology, 2019
Systemic lupus erythematosus (SLE) is characterized by the production of antibodies against self antigens. However, the events underlying autoantibody formation in SLE remain unclear.
Elizabeth Ogunrinde, Zejun Zhou, Zhenwu Luo, A. Alekseyenko, Quanzhen Li, Danielle Macedo, D. Kamen, J. Oates, G. Gilkeson, Wei Jiang   +9 more
semanticscholar   +1 more source

Anti-BIRC5 autoantibody serves as a valuable biomarker for diagnosing AFP-negative hepatocellular carcinoma [PDF]

PeerJ
Background Autoantibodies targeting tumor-associated antigens (TAAbs) have emerged as promising biomarkers for early cancer detection. This research aimed to assess the diagnostic capacity of anti-BIRC5 autoantibody in detecting AFP-negative ...
Qing Li, Haiyan Liu, Han Wang, Wenzhuo Xiong, Liping Dai, Xiuzhi Zhang, Peng Wang, Hua Ye, Jianxiang Shi, Zhihao Fang, Keyan Wang   +10 more
doaj   +2 more sources

The sensitivity and specificity of platelet autoantibody testing in immune thrombocytopenia: a systematic review and meta‐analysis of a diagnostic test

Journal of Thrombosis and Haemostasis, 2019
Essentials The diagnosis of ITP is based on a platelet count < 100 × 109 L−1 and exclusion of other causes. There are no standard tests or biomarkers to diagnose ITP. The sensitivity of platelet autoantibody testing is low (53%). The specificity is high (
J. Vrbensky, Joyce Moore, D. Arnold, James W. Smith, J. Kelton, I. Nazy   +5 more
semanticscholar   +1 more source

A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort [PDF]

, 2010
<p><b>Objectives</b> The aim of this study was to confirm the influence of TNFSF4 polymorphisms on systemic sclerosis (SSc) susceptibility and phenotypic features.</p> <p><b>Methods</b> A total of 8 European ...
A E Voskuyl, A Fernández-Nebro, A Herrick, A J Schuerwegh, A Kreuter, A Nordin, A Pros, B A Lie, B P Koeleman, B Rueda, C Denton, C Fonseca, C P Simeon, C Tolosa, E De Langhe, E Vicente-Rabaneda, F De Keyser, F Houssiau, F J García-Hernández, G Espinosa, G Riemekasten, H Manku, I Castellví, I Gómez-Gracia, J A Román-Ivorra, J M van Laar, J Martín, J Worthington, JCA Broen, K Claes, L Beretta, L Bossini-Castillo, L Padykov, L Rodríguez, M A González-Gay, M C Vonk, M F González-Escribano, M Gallego, M M Chee, M T Camps, M V Egurbide, MJ Gough, MJH Coenen, N Hunzelmann, N Navarrete, N Ortego-Centeno, P Airó, P Carreira, P García de la Peña, P Gourh, P Shiels, R Hesselstrand, R Madhok, R Scorza, R Westhovens, T Witte, TRDJ Radstake, V Follonosa, V Smith, Ø Palm   +59 more
core   +5 more sources

Islet Autoantibody Standardization Program 2018 Workshop: Interlaboratory Comparison of Glutamic Acid Decarboxylase Autoantibody Assay Performance.

Clinical Chemistry, 2019
BACKGROUND The Islet Autoantibody Standardization Program (IASP) aims to improve the performance of immunoassays measuring type 1 diabetes (T1D)-associated autoantibodies and the concordance of results among laboratories.
V. Lampasona, David L. Pittman, A. Williams, P. Achenbach, M. Schlosser, B. Akolkar, W. Winter   +6 more
semanticscholar   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Case report: Amnestic mild cognitive impairment in multiple domains associated with neurofascin 186 autoantibodies: Case series with follow-up and review

Frontiers in Psychiatry, 2023
BackgroundNeurofascin 186 autoantibodies are known to occur with a diseased peripheral nervous system. Recently, also additional central nervous system (CNS) involvement has been reported in conjunction with neurofascin 186 autoantibodies.
Niels Hansen, Niels Hansen, Anne Sagebiel, Kristin Rentzsch, Sina Hirschel, Jens Wiltfang, Jens Wiltfang, Jens Wiltfang, Björn H. Schott, Björn H. Schott, Björn H. Schott, Bartels Claudia   +11 more
doaj   +1 more source

Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application [PDF]

, 2016
Background The insulinoma associated protein tyrosine phosphatase 2 (IA-2) is one of the immunodominant autoantigens involved in the autoimmune attack to the beta-cell in Type 1 Diabetes Mellitus.
A Trabucchi, A Trabucchi, A Trabucchi, A Villalba, A Villalba, A Westerlund-Karlsson, Adriana Victoria Sabljic, AG Krochik, AL Notkins, Aldana Trabucchi, BD Spangler, Bruno David Rovitto, C Levy-Marchal, C Tiberti, C Torn, CA Baer, CC Richardson, CF Verge, D Barford, DU Rabin, DU Rabin, E Bonifacio, E Bonifacio, E Kawasaki, EA Gale, Edgardo Poskus, ELD Harlow, ER LaVallie, ER LaVallie, ET Mambetisaeva, Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, F Baneyx, F Sodoyez-Goffaux, G Hannig, GS Eisenbarth, H Goetz, H Mziaut, H Mziaut, H Shägger, H Xie, I Kikkas, J Sambrook, J Seissler, J Suckale, JA Berzofsky, JA Berzofsky, JA Dromey, JC Sodoyez, JM Gonzalez-Buitrago, JM Wenzlau, JP Palmer, K Lobner, KT Elvers, L Castano, LL Guerra, Luciano Lucas Guerra, M Hawa, M Knip, M Masuda, M Solimena, M Trajkovski, M Trajkovski, MA Payton, ML Papouchado, ML Papouchado, MP Sica, MS Lan, MS Lan, Natalia Inés Faccinetti, NG Morgenthaler, O Pines, P Tompa, PD Burbelo, PJ Bingley, PZ Zimmet, R Gianani, R Turner, RD Hoffman, RR Stumpo, Ruben Francisco Iacono, S Chen, S Krause, S Schubert, S Torii, Silvina Noemí Valdez, SJ Kim, SLBP Thrower, SN Valdez, SN Valdez, T Ort, T Tuomi, VN Uversky, WA Hagopian, X Jia, X Palomer, Z Zhao   +95 more
core   +5 more sources

Individual and stable autoantibody repertoires in healthy individuals

Autoimmunity, 2019
In the era towards precision medicine, we here present the individual specific autoantibody signatures of 193 healthy individuals. The self-reactive IgG signatures are stable over time in a way that each individual profile is recognized in longitudinal ...
M. Neiman, C. Hellström, D. Just, C. Mattsson, Linn Fagerberg, I. Schuppe-Koistinen, A. Gummesson, G. Bergström, O. Kallioniemi, A. Achour, R. Sallinen, M. Uhlén, P. Nilsson   +12 more
semanticscholar   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source