Results 51 to 60 of about 142,317 (291)

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

Anti-TIF-1γ Antibody Detection Using a Commercial Kit vs In-House Immunoblot: Usefulness in Clinical Practice

Frontiers in Immunology, 2021
ObjectivesAnti-TIF-1γ autoantibody detection is important for cancer screening in patients with dermatomyositis. The gold standard for anti-TIF-1γ detection, immunoprecipitation, is only available from a few specialized laboratories worldwide, so ...
Anaís Mariscal, Milena Milán, Andrés Baucells, Maria Angeles Martínez, Andrea Garcia Guillen, Ernesto Trallero-Araguás, Marcelo Alvarado-Cardenas, Laura Martínez-Martínez, Laura Martínez-Martínez, Leticia Alserawan, Teresa Franco-Leyva, María Teresa Sanz-Martínez, Laura Viñas-Giménez, Hector Corominas, Cándido Juárez, Cándido Juárez, Iván Castellví, Iván Castellví, Albert Selva-O’Callaghan, Albert Selva-O’Callaghan   +19 more
doaj   +1 more source

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase A autoantibody, and C‐reactive protein for early detection of malignant tumors in dogs

Journal of Veterinary Internal Medicine
Background Although the importance of early diagnosis of malignant tumors is a major concern, an easily accessible in‐house method has not been established.
Yoonhee Kim, Wonhee Lee, Byunggak Kim, Bonghwan Jang, Kyung‐Rok Yu, Hong Sook Kim, Minok Ryu, Yein Oh, Kyoungwon Seo, Chul Park, Ulsoo Choi, Dongha Bhang, Hwayoung Youn   +12 more
doaj   +1 more source

Risk Factors for Mucosal Involvement in Bullous Pemphigoid and the Possible Mechanism: A Review

Frontiers in Medicine, 2021
Bullous pemphigoid (BP) is the most common type of autoimmune bullous disease and is characterized by the presence of circulating anti-BP180 and/or anti-BP230 autoantibodies.
Xinyi Chen, Wenlin Zhao, Hongzhong Jin, Li Li   +3 more
doaj   +1 more source

Cancer biomarkers, and novel techniques for detection [PDF]

, 2017
Technologies for early detection of tumors is critical for better therapy outcome and overall change in cancer survival. These assays must be capable of detecting tumors at early stages in order to prevent metastasis of the tumor and help reduce ...
Jamal, Tameem
core  

Daratumumab Treatment for Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP): A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune‐mediated neuropathy featuring progressive weakness, sensory deficits, and areflexia. While corticosteroids, intravenous immunoglobulin, and plasmapheresis are effective first‐line immunotherapies, a subset of patients remains treatment‐refractory.
Xueyu Zhang, Jianli Zhao, Xue Zhao, Xiaowei Hu, Zichun Xiao, Jie Wu, Xiaowen Li, Jing Xu, Yu‐Jing Li   +8 more
wiley   +1 more source

The interference of anti-TSH autoantibody on clinical TSH detection

Frontiers in Endocrinology
ObjectiveIt is well known that macro-thyroid-stimulating hormone (macro-TSH) could interfere with the detection of TSH. The anti-TSH autoantibody is an essential component of macro-TSH.
Mulin Tang, Xue Meng, Jiajia Ni, Xue Liu, Xinhui Wang, Yuchen Li, Yuwei Chai, Chunjia Kou, Li Zhang, Haiqing Zhang, Haiqing Zhang, Haiqing Zhang, Haiqing Zhang   +12 more
doaj   +1 more source

Oxidative stress in the pathogenesis of systemic scleroderma: An overview [PDF]

, 2018
Systemic sclerosis (SSc) is a rare disorder of the connective tissue characterized by fibrosis of the skin, skeletal muscles and visceral organs. Additional manifestations include activation of the immune system and vascular injury. SSc causes disability
Gambardella, Lucrezia, Giovannetti, Antonello, Malorni, Walter, Pietraforte, Donatella, Straface, Elisabetta, Vona, Rosa   +5 more
core   +1 more source

Cancer Risk in Patients With Systemic Sclerosis: A Nationwide Cohort Study in South Korea 2004 to 2021

Arthritis Care &Research, EarlyView.
Objective Systemic sclerosis (SSc) is a rare autoimmune disease characterized by tissue fibrosis, vasculopathy, and immune dysregulation. Our objectives were to quantify the overall and site‐specific cancer risks in patients with SSc compared to the general population, examine temporal trends in cancer incidence following SSc diagnosis, and explore ...
Jihyun Na, Su Jin Choi, Sojeong Park, Minae Park, Doo‐Ho Lim   +4 more
wiley   +1 more source