Results 61 to 70 of about 228,187 (396)

Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus. [PDF]

, 2016
High titer, class-switched autoantibodies are a hallmark of systemic lupus erythematosus (SLE). Dysregulation of the interferon (IFN) pathway is observed in individuals with active SLE, although the association of specific autoantibodies with chemokine ...
Baechler, Emily C, Balboni, Imelda M, Diep, Vivian K, Haddon, D James, Hall, Drew A, Lee, Jung-Rok, Petri, Michelle, Price, Jordan V, Utz, Paul J, Wand, Hannah E, Wang, Shan X   +10 more
core   +2 more sources

Anti-BIRC5 autoantibody serves as a valuable biomarker for diagnosing AFP-negative hepatocellular carcinoma [PDF]

PeerJ
Background Autoantibodies targeting tumor-associated antigens (TAAbs) have emerged as promising biomarkers for early cancer detection. This research aimed to assess the diagnostic capacity of anti-BIRC5 autoantibody in detecting AFP-negative ...
Qing Li, Haiyan Liu, Han Wang, Wenzhuo Xiong, Liping Dai, Xiuzhi Zhang, Peng Wang, Hua Ye, Jianxiang Shi, Zhihao Fang, Keyan Wang   +10 more
doaj   +2 more sources

Case Report: Variety of Target Antigens During 1 Year Follow-Up of a Patient Initially Diagnosed With Bullous Pemphigoid

Frontiers in Immunology, 2022
Autoimmune bullous diseases (AIBDs), presenting cutaneous and/or mucosal bullous lesions, are classified into pemphigus and pemphigoid diseases. A longtime observation for complicated AIBD cases is rarely reported.
Hua Qian, Zhijun Zhou, Luhuai Shi, Huicheng Li, Weijun Liu, Yong Ai, Yangmin Gao, Suying Feng, Takashi Hashimoto, Xiaoguang Li   +9 more
doaj   +1 more source

Depressed serum IgM levels in SLE are restricted to defined subgroups [PDF]

, 2017
Natural IgM autoantibodies have been proposed to convey protection from autoimmune pathogenesis. Herein, we investigated the IgM responses in 396 systemic lupus erythematosus (SLE) patients, divided into subgroups based on distinct autoantibody profiles. Depressed IgM levels were more common in SLE than in matched population controls.
arxiv   +1 more source

The sensitivity and specificity of platelet autoantibody testing in immune thrombocytopenia: a systematic review and meta‐analysis of a diagnostic test

Journal of Thrombosis and Haemostasis, 2019
Essentials The diagnosis of ITP is based on a platelet count < 100 × 109 L−1 and exclusion of other causes. There are no standard tests or biomarkers to diagnose ITP. The sensitivity of platelet autoantibody testing is low (53%). The specificity is high (
J. Vrbensky, Joyce Moore, D. Arnold, James W. Smith, J. Kelton, I. Nazy   +5 more
semanticscholar   +1 more source

Eculizumab is a safe and effective treatment in pediatric patients with atypical hemolytic uremic syndrome [PDF]

, 2016
Atypical hemolytic uremic syndrome (aHUS) is caused by alternative complement pathway dysregulation, leading to systemic thrombotic microangiopathy (TMA) and severe end-organ damage.
Al-Akash, Samhar I, Ardissino, Gianluigi, Bedrosian, Camille L, Evans, Jonathan, Fila, Marc, Greenbaum, Larry A, Henning, Paul, Licht, Christoph, Lieberman, Kenneth V, Maringhini, Silvio, Ogawa, Masayo, Pape, Lars, Rees, Lesley, van de Kar, Nicole CAJ, Vande Walle, Johan   +14 more
core   +2 more sources

Value of Autoantibody Expression During Long-Term Follow-Up in Paediatric ALL Patients After Allogeneic Haematopoietic Stem Cell Transplantation

Frontiers in Pediatrics, 2021
Objectives: Chronic graft-versus-host disease (cGvHD) following haematopoietic stem cell transplantation (HSCT) shares many similarities with de novo autoimmune disorders, being associated with the presence of autoantibodies.
Anita Lawitschka, Anita Lawitschka, Leila Ronceray, Dorothea Bauer, Michael Rittenschober, Natalia Zubarovskaya, Rene Geyeregger, Winfried F. Pickl, Zoya Kuzmina   +8 more
doaj   +1 more source

Individual and stable autoantibody repertoires in healthy individuals

Autoimmunity, 2019
In the era towards precision medicine, we here present the individual specific autoantibody signatures of 193 healthy individuals. The self-reactive IgG signatures are stable over time in a way that each individual profile is recognized in longitudinal ...
M. Neiman, C. Hellström, D. Just, C. Mattsson, Linn Fagerberg, I. Schuppe-Koistinen, A. Gummesson, G. Bergström, O. Kallioniemi, A. Achour, R. Sallinen, M. Uhlén, P. Nilsson   +12 more
semanticscholar   +1 more source

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

Autoantigen Microarray for High-throughput Autoantibody Profiling in Systemic Lupus Erythematosus

Genomics, Proteomics & Bioinformatics, 2015
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the production of autoantibodies to a broad range of self-antigens. Profiling the autoantibody repertoire using array-based technology has emerged as a powerful tool for ...
Honglin Zhu, Hui Luo, Mei Yan, Xiaoxia Zuo, Quan-Zhen Li   +4 more
doaj   +1 more source