Results 101 to 110 of about 33,778 (258)

Vaccination as a Promising Approach in Cardiovascular Risk Mitigation: Are We Ready to Embrace a Vaccine Strategy?

Biomolecules
Cardiovascular disease (CVD) remains a leading global health concern, with atherosclerosis being its principal cause. Standard CVD treatments primarily focus on mitigating cardiovascular (CV) risk factors through lifestyle changes and cholesterol ...
Georgios Tsioulos, Natalia G. Vallianou, Alexandros Skourtis, Maria Dalamaga, Evangelia Kotsi, Sofia Kargioti, Nikolaos Adamidis, Irene Karampela, Iordanis Mourouzis, Dimitris Kounatidis   +9 more
doaj   +1 more source

Sclera-Specific and non-sclera-specific autoantibodies in the serum of patients with non-infectious anterior scleritis Auto-anticorpos contra antígenos específicos e não-específicos da esclera no soro de pacientes com esclerite anterior não-infecciosa

Revista Brasileira de Reumatologia, 2007
OBJECTIVES: to study the frequency and specificity of sclera-specific and non-sclera-specific autoantibodies in the sera of patients with anterior non-infectious scleritis. METHODS: prospective study involving 25 patients examined at the sector of Cornea
Wagner Koji Aragaki, Luciene Barbosa de Sousa, Virgínia Fernandes Moça Trevisani, Hellen Fuzzi, Luís Eduardo Coelho Andrade   +4 more
doaj   +1 more source

Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance

Immunology, EarlyView.
Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos, Vitor Marcel Faça, Eduardo Antonio Donadi, Ana Paula Masson, Carlos Crippa Coletto, Gustavo Ronconi Roza   +5 more
wiley   +1 more source

Candidate autoantigens selected for analysis of their tissue expression pattern.

, 2016
Candidate autoantigens selected for analysis of their tissue expression pattern.
Carmen Theek (849767), Georg Schaefer (849765), Zlatko Trajanoski (15774), Klaus Marquart (849766), Bettina Schlick (849762), Angelika Lueking (647656), Helmut Klocker (261562), Dirk Zielinski (849769), Peter Schulz-Knappe (849771), Matthias Kirchner (849770), Petra Massoner (279204), Mark A. Rubin (257147), Peter Amersdorfer (849768), Stefan Müllner (647657), Mirjam Blattner (849764), Pornpimol Charoentong (849763)   +15 more
core   +1 more source

Pathophysiology and emerging treatments for dermographic, cholinergic and cold urticaria

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review illustrates key proposed mast cell‐mediated activation pathways in dermographic, cholinergic and cold urticaria, highlighting IgE‐dependent and ‐independent mechanisms. These pathways are increasingly targeted by emerging drugs, aiming to interrupt mast cell activation and mediator release, offering more precise, mechanism‐based treatment ...
Mojca Bizjak‐Suran, Matjaž Fležar, Manuel Pedro Pereira   +2 more
wiley   +1 more source

Novel autoantigens in autoimmune hypophysitis

, 2008
BACKGROUND: Pituitary autoantibodies are found in autoimmune hypophysitis and other conditions. They are a marker of pituitary autoimmunity but currently have limited clinical value.
TZOU SC, CATUREGLI P., MARTINO, ENIO, GUTENBERG A, LUPI I, BROMAN KW   +5 more
core   +2 more sources

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Profiling of alopecia areata autoantigens based on protein microarray technology [PDF]

, 2005
Protein biochips have a great potential in future parallel processing of complex samples as a research tool and in diagnostics. For the generation of protein biochips, highly automated technologies have been developed for cDNA expression library ...
Lueking, A., Hensel-Wiegel, K., Meyer, Helmut E., Tauber, Rudolf, Wirths, Christopher, Cahill, Dolores J., Huber, O., Lehrach, Hans, Blume-Peytavi, Ulrike, Schulte, K., Tauber, R., Lehrach, H., Kowald, Axel, Hensel-Wiegel, Karin, Schulte, Kirsten, Stieler, K., Lueking, Angelika, Blume-Peytavi, U., Meyer, H., Stieler, Karola M., Cahill, D., Wirths, C., Kowald, A., Huber, Otmar   +23 more
core   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Autoantigens found in the NPSLE and non-NPSLE groups.

, 2016
(A). Venn Diagram of autoantigen distribution. (B). Distribution of autoantigens in various positive ranges /
Wei Huang (36889), Fengchun Zhang (309978), Lin Wu (153444), Xuan Zhang (56049), Chaojun Hu (687165), Guang Song (733747), Qiang Shan (195130), Heng Zhu (50460), Yongzhe Li (528191), Hua Chen (43790), Ping Li (31981)   +10 more
core   +1 more source