Results 101 to 110 of about 5,372 (258)

Evolution of the SARS‐CoV‐2 Main Protease Under Fitness Constraints Imposed by Folding Stability and Activity

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continues to evolve and diversify, leading to the emergence of immune‐evasive variants and underscoring the need for complementary antiviral strategies targeting conserved viral machinery. In this context, the main protease (Mpro) represents a potential therapeutic target because
David Ferreiro, Miguel Arenas
wiley   +1 more source

Towards open-ended evolution in self-replicating molecular systems

Beilstein Journal of Organic Chemistry, 2017
In this review we discuss systems of self-replicating molecules in the context of the origin of life and the synthesis of de novo life. One of the important aspects of life is the ability to reproduce and evolve continuously.
Herman Duim, Sijbren Otto
doaj   +1 more source

Toxicity of Various Pyrolysis Liquids From Biosolids on Methane Production Yield

Frontiers in Energy Research, 2019
Aqueous pyrolysis liquid (APL) is a high-COD byproduct of wastewater biosolids pyrolysis that is comprised of numerous complex organic compounds and ammonia nitrogen (NH3-N). One potential beneficial use of APL is as a co-digestate to produce more biogas
Saba Seyedi, Kaushik Venkiteshwaran, Daniel Zitomer   +2 more
doaj   +1 more source

Gramine Suppresses Myofibroblast Activation and ECM Accumulation in Renal Fibrosis by Targeting the NF‐κB/NLRP3 and TGF‐β1/Smad Pathways

Phytotherapy Research, EarlyView.
ABSTRACT Chronic kidney disease (CKD) is driven by persistent inflammation and progressive fibrosis, leading to irreversible renal damage. Gramine (GMN), an indole alkaloid, has broad pharmacological benefits. However, its therapeutic potential against renal fibrosis remains unexplored.
Shobhit Gairola, Archana Bhatta, Tushar Mishra, Ravinder K. Kaundal   +3 more
wiley   +1 more source

Enantioselective Synthesis Induced by Chiral Crystal Composed of dl-Serine in Conjunction with Asymmetric Autocatalysis

, 2016
Asymmetric autocatalysis initiated by chiral crystals containing racemic dl-serine was achieved. P- and M-crystals of dl-serine acted as the source of chirality of asymmetric autocatalysis to afford highly enantioenriched (>99.5% ee) (S)- and (R ...
Kenta Suzuki (204780), Tsuneomi Kawasaki (1269294), Taisuke Sasagawa (2202799), Kenso Soai (1269288), Mizuki Uchida (2202805), Kazuya Shiozawa (2202802)   +5 more
core   +1 more source

Tailored Molecular Scissor Unlocks the Autocatalytic Potential of Hybridization Chain Reaction for Tunable Signal Amplification

Small, EarlyView.
We establish a recycling chain reaction (RCR) using a single hairpin, H3, which disassembles HCR assemblies to unlock the inherent autocatalytic potential of HCR. Conventional HCR is redefined as the fully constrained state (H3 = 0) of RCR. Tuning H3 ratios enables dynamic control over DNA assembly, providing a compact platform for biomolecular ...
Ting Li, Kaiqi Hu, Jiaying Li, Ying Yi Lee, Kin Ming Kwan, Hung‐Wing Li   +5 more
wiley   +1 more source

Fluorinated copolymer resists for high‐resolution negative‐tone lithography: Preparation and patterning performance

Smart Molecules, EarlyView.
Electron‐beam induced C–F cleavage in –CF3 generates F−, which abstracts a proton to form the acid that catalyzes tBMA deprotection during post‐exposure baking. This self‐sensitization mechanism enables the precise formation of high‐resolution negative‐tone patterns with enhanced sensitivity and resolution.
Yuting Tang, Wenzheng Li, Xinyan Huang, Min Zhang, Han Han, Jialong Zhang, Qinyu Luo, Jiangli Fan, Pengzhong Chen, Xiaojun Peng   +9 more
wiley   +1 more source

Autocatalysis, Autopoiesis, and the Opportunity Cost of Individuality

Biomimetics
Ever since Varela and Maturana proposed the concept of autopoiesis as the minimal requirement for life, there has been a focus on cellular systems that erect topological boundaries to separate themselves from their surrounding environment.
Nemanja Kliska, Chrystopher L. Nehaniv
doaj   +1 more source

Recent advances in polymeric chemically amplified positive resists: Materials and design strategies

Smart Molecules, EarlyView.
This review summarizes recent advances in the molecular design of positive chemically amplified resists, focusing on photoacid generators and polymer architectures. Key strategies for enhancing sensitivity—including self‐amplification effects, copolymerization of sensitive monomers, controlled polymerization, and photosensitized chemically amplified ...
Litao Zhou, Haoyuan Li, Jianhua Zhang, Hanshen Xin   +3 more
wiley   +1 more source

Investigation of the Reoxidation and Material Behavior of Directly Reduced Pellets and Fines Under Simulated Rail Transport Conditions

steel research international, EarlyView.
The study investigates the reoxidation behavior of DRI pellets (Midrex and H2‐reduced) under realistic conditions, considering the test parameters of temperature, humidity, storage duration, particle size (including fine fraction), and container geometry. The samples are analyzed based on mass changes.
Bernd Taferner, Johannes Schenk, Richard Schanner, Peter Gluschitz, Jan Eisbacher‐Lubensky   +4 more
wiley   +1 more source