Results 101 to 110 of about 9,492,165 (393)

Interleukin-35 Induces Regulatory B Cells that Suppress CNS Autoimmune Disease

Nature Network Boston, 2014
Interleukin-10 (IL-10)-producing regulatory B (Breg) cells suppress autoimmune disease, and increased numbers of Breg cells prevent host defense to infection and promote tumor growth and metastasis by converting resting CD4+ T cells to regulatory T (Treg)
R. Wang, C. Yu, I. Dambuza, R. Mahdi, M. Dolinska, Yuri V. Sergeey, P. Wingfield, Sung-hye Kim, C. Egwuagu   +8 more
semanticscholar   +1 more source

Combined Systemic Immunotherapy and Intrathecal Dexamethasone in Febrile Infection Related Epilepsy Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Febrile infection related epilepsy syndrome (FIRES) is a rare presentation of refractory status epilepticus with immune dysregulation as a potential pathologic mechanism. Despite promising results from second‐line immunomodulators, approximately 30% remain refractory to treatment.
Kristen S. Fisher, Alexander Ankar, Jon Cokley, Eyal Muscal, James J. Riviello, Yi‐Chen Lai   +5 more
wiley   +1 more source

Omics approaches open new horizons in major depressive disorder: from biomarkers to precision medicine

Frontiers in Psychiatry
Major depressive disorder (MDD) is a recurrent episodic mood disorder that represents the third leading cause of disability worldwide. In MDD, several factors can simultaneously contribute to its development, which complicates its diagnosis. According to
Fabiola Stolfi, Fabiola Stolfi, Hugo Abreu, Hugo Abreu, Riccardo Sinella, Riccardo Sinella, Sara Nembrini, Sara Nembrini, Sara Centonze, Sara Centonze, Virginia Landra, Claudio Brasso, Giuseppe Cappellano, Giuseppe Cappellano, Paola Rocca, Annalisa Chiocchetti, Annalisa Chiocchetti   +16 more
doaj   +1 more source

Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases

JAMA Neurology, 2017
Importance Recent genome-wide association studies (GWAS) and pathway analyses supported long-standing observations of an association between immune-mediated diseases and Parkinson disease (PD).
Aree Witoelar, I. Jansen, Yunpeng Wang, R. Desikan, J. R. Gibbs, C. Blauwendraat, W. Thompson, D. Hernandez, S. Djurovic, A. Schork, F. Bettella, D. Ellinghaus, A. Franke, B. Lie, L. McEvoy, T. Karlsen, S. Lesage, H. Morris, A. Brice, N. Wood, P. Heutink, J. Hardy, A. Singleton, A. Dale, T. Gasser, O. Andreassen, M. Sharma   +26 more
semanticscholar   +1 more source

High‐Throughput Immunoassays for Cavin‐4 IgG: A Diagnostic Tool for Immune‐Mediated Rippling Muscle Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACTCavin‐4 was identified as a potential autoantigen for immune‐mediated rippling muscle disease (iRMD). To validate this, we developed and tested various immunoassays, including a cell‐based assay (CBA), cavin‐4 recombinant protein ELISA, and multi‐peptide ELISA. Among 19 iRMD patients, all exhibited muscle rippling, and 13 had percussion‐induced
Reghann G. LaFrance‐Corey, Haidara Kherbek, Nimalan Harinesan, Margherita Milone, Naveen K. Paramasivan, Pallab Sarker, Andrew M. Knight, Carley Karsten, Surendra Dasari, Teerin Liewluck, William J. Litchy, Sean J. Pittock, John R. Mills, Divyanshu Dubey   +13 more
wiley   +1 more source

A systematic review of the incidence and prevalence of autoimmune disease in multiple sclerosis

Multiple Sclerosis, 2015
Background: As new therapies emerge which increase the risk of autoimmune disease it is increasingly important to understand the incidence of autoimmune disease in multiple sclerosis (MS).
R. Marrie, Nadia Reider, Jeffrey A. Cohen, O. Stuve, P. Sørensen, G. Cutter, S. Reingold, M. Trojano   +7 more
semanticscholar   +1 more source

Unleashing the Power of Multiomics: Unraveling the Molecular Landscape of Peripheral Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Peripheral neuropathies (PNs) affect over 20 million individuals in the United States, manifesting as a wide range of sensory, motor, and autonomic nerve symptoms. While various conditions such as diabetes, metabolic disorders, trauma, autoimmune disease, and chemotherapy‐induced neurotoxicity have been linked to PN, approximately one‐third of
Julie Choi, Zitian Tang, Wendy Dong, Jenna Ulibarri, Elvisa Mehinovic, Simone Thomas, Ahmet Höke, Sheng Chih Jin   +7 more
wiley   +1 more source

Parkinson disease is a TH17 dominant autoimmune disorder against accumulated alpha-synuclein [PDF]

arXiv, 2013
Parkinson disease is a very common neurodegenerative disorder. Patients usually undergo destruction of substantia nigra to develop typical symptoms such as resting tremor, hypokinesia, and rigidity. However, the exact mechanism of Parkinson disease is still unknown, so it is called idiopathic Parkinsonism.
arxiv  

Recent advances in understanding autoimmune thyroid disease: the tallest tree in the forest of polyautoimmunity

F1000Research, 2017
Autoimmune thyroid disease (AITD) is often observed together with other autoimmune diseases. The coexistence of two or more autoimmune diseases in the same patient is referred to as polyautoimmunity, and AITD is the autoimmune disease most frequently ...
S. Bliddal, C. Nielsen, U. Feldt-Rasmussen   +2 more
semanticscholar   +1 more source

The Impact of In‐Hospital Disease Modifying Treatments on Mental and Physical Burden in Caregiver of Patients With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with multiple sclerosis (pwMS) may require a high level of daily assistance both for indoor and outdoor activities. Usually, relatives or friends provide daily support to MS patients who have lost personal autonomy. Several factors such as disability level and disease duration may affect the burden of care in caregivers of ...
Giuseppe Schirò, Salvatore Iacono, Michele Andolina, Gabriele Sorbello, Andrea Calì, Erika Gentile, Marco D'Amelio, Paolo Aridon, Giuseppe Salemi, Paolo Ragonese   +9 more
wiley   +1 more source