Results 31 to 40 of about 9,605,298 (318)

Autoimmune Disease in Women: Endocrine Transition and Risk Across the Lifespan

Frontiers in Endocrinology, 2019
Women have a higher incidence and prevalence of autoimmune diseases than men, and 85% or more patients of multiple autoimmune diseases are female. Women undergo sweeping endocrinological changes at least twice during their lifetime, puberty and menopause,
Maunil K. Desai, R. Brinton
semanticscholar   +1 more source

Establishment of an induced pluripotent stem cell line SPHi001-A from a systemic lupus erythematosus patient combined with preeclampsia and psoriasis

Stem Cell Research, 2021
Systemic lupus erythematosus (SLE) is a heterogeneous, autoimmune disease that can affect multiple organs and systems such as skin, joints, kidneys, hematologic system or central nervous system.
Dandan Li, Xiaoping Hong, Weilong Li, Shuhui Meng, Haiyan Yu, Xinzhou Zhang, Cuihua Wang, Igor M. Samokhvalov, Dongzhou Liu, Donge Tang, Yong Dai   +10 more
doaj  

Genetic and Epigenetic Fine-Mapping of Causal Autoimmune Disease Variants

Nature, 2014
Genome-wide association studies have identified loci underlying human diseases, but the causal nucleotide changes and mechanisms remain largely unknown.
K. Farh, K. Farh, A. Marson, Jiang Zhu, Markus Kleinewietfeld, Markus Kleinewietfeld, Markus Kleinewietfeld, William J. Housley, Samantha P. Beik, N. Shoresh, Holly J. Whitton, Russell J. H. Ryan, Russell J. H. Ryan, Alexander A. Shishkin, Alexander A. Shishkin, Meital Hatan, M. Carrasco-Alfonso, Dita Mayer, C. J. Luckey, N. Patsopoulos, N. Patsopoulos, P. Jager, P. Jager, V. Kuchroo, C. Epstein, M. J. Daly, M. J. Daly, D. Hafler, D. Hafler, B. Bernstein   +29 more
semanticscholar   +1 more source

Multiomics landscape of the autosomal dominant osteopetrosis type II disease-specific induced pluripotent stem cells

Hereditas, 2021
Background Autosomal dominant osteopetrosis type II (ADO2) is a genetically and phenotypically metabolic bone disease, caused by osteoclast abnormalities.
Chunhong Li, Yu Shangguan, Peng Zhu, Weier Dai, Donge Tang, Minglin Ou, Yong Dai   +6 more
doaj   +1 more source

Autoimmune Disease-Associated Hypertension

Current Hypertension Reports, 2019
Purpose of ReviewTo highlight important new findings on the topic of autoimmune disease-associated hypertension.Recent FindingsAutoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis are associated with an increased risk for ...
V. Wolf, M. Ryan
semanticscholar   +1 more source

Quality of life in mild and severe alopecia areata patients

International Journal of Women's Dermatology, 2018
Background: Alopecia areata is a relapsing hair disorder characterized by a sudden hairloss and has a considerable impact on patient’s quality of life. The goal of this study was to determine quality of life among patients with mild and severe forms of ...
Robabeh Abedini, Zahra Hallaji, Vahideh Lajevardi, Maryam Nasimi, Mona Karimi Khaledi, Hamid Reza Tohidinik   +5 more
doaj   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Limited statistical evidence for shared genetic effects of eQTLs and autoimmune disease-associated loci in three major immune cell types

Nature Genetics, 2017
Most autoimmune-disease-risk effects identified by genome-wide association studies (GWAS) localize to open chromatin with gene-regulatory activity. GWAS loci are also enriched in expression quantitative trait loci (eQTLs), thus suggesting that most risk ...
S. Chun, Alexandra Casparino, N. Patsopoulos, Damien C. Croteau-Chonka, B. Raby, P. D. De Jager, S. Sunyaev, C. Cotsapas   +7 more
semanticscholar   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source