Results 61 to 70 of about 885,466 (342)

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Case of a 35‐Year‐Old Man With Pain With Sneezing and Leg Weakness Causing Collapse

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This case details a 35‐year‐old man with no past medical history who presents with acute paraparesis and urinary retention in the setting of progressive paresthesias and weakness of his lower and upper extremities over several months. He was found to have longitudinally extensive transverse myelitis involving the cervical to mid‐thoracic cord ...
Joey Hsu, Karen Schoedel, Alan Plotzker, Leana Doherty   +3 more
wiley   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis [PDF]

, 2010
Recent genetic studies have led to identification of numerous loci that are associated with susceptibility to autoimmune diseases. The strategy of using information from these studies has facilitated the identification of novel juvenile idiopathic ...
Barton, A., British Society of Paediatric and Adolescent Rheumatology (BSPAR) Study Group, Childhood Arthritis Prospective Study (CAPS), Eyre, S., Flynn, E., Gardner-Medwin, J. [CAPS and BSPAR study groups], Hinks, A., Ke, X., Martin, P., Packham, J., Thomson, W., UKRAG Consortium, Worthington, J.   +12 more
core   +1 more source

Probiotic-derived extracellular vesicles: the next breakthrough in postbiotics for rheumatoid arthritis

Frontiers in Immunology
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammation and joint damage. Emerging evidence highlights the role of gut and oral microbiota in RA pathogenesis, with microbial dysbiosis potentially exacerbating ...
Federica Dell’Atti, Federica Dell’Atti, Hugo Abreu, Hugo Abreu, Patrizia Malfa, Davide Raineri, Davide Raineri, Giuseppe Cappellano, Giuseppe Cappellano, Annalisa Chiocchetti, Annalisa Chiocchetti   +10 more
doaj   +1 more source

The potential roles of herpesvirus and cytomegalovirus in the exacerbation of pemphigus vulgaris

Dermatology Practical & Conceptual, 2018
Background: Among exogenous etiologies, the critical role of microbial agents such as herpesviruses (HSV1/2) and cytomegalovirus (CMV) in triggering and flaring autoimmune conditions such as pemphigus vulgaris (PV) has been recently discovered ...
Fariba Mohammadi, Zahra Khalili, Sayed Mahdi Marashi, Amirhoushang Ehsani, Maryam Daneshpazhooh, Majid Teymoori-Rad, Kamran Balighi, Ahmad Nejati, Shohreh Shahmahmoodi, Shima Izadidakhrabadi, Hamidreza Mahmoudi, Pedram Noormohammadpour   +11 more
doaj   +1 more source

Apeced in Turkey: a case report and insights on genetic and phenotypic variability [PDF]

, 2018
APECED is a rare monogenic recessive disorder caused by mutations in the AIRE gene. In this manuscript, we report a male Turkish patient with APECED syndrome who presented with chronic mucocutaneous candidiasis associated with other autoimmune ...
Alessandra Fierabraccia, Corrado Betterle, FRASCA, FEDERICA, Marsha Pellegrino, Sara Sebnem Kilic   +4 more
core   +1 more source

Connection between Celiac Disease and Systemic Lupus Erythematosus in Children—A Development Model of Autoimmune Diseases Starting from What We Inherit to What We Eat [PDF]

, 2023
Vasile Valeriu Lupu, Elena Jechel, Cristina Maria Mihai, Elena Cristina Mitrofan, Ancuța Lupu, Iuliana Magdalena Stârcea, Silvia Fotea, Adriana Mocanu, Dragos Catalin Ghica, Costică Mitrofan, Dragoş Munteanu, Delia Lidia Șalaru, Ionela Daniela Morariu, Ileana Ioniuc   +13 more
openalex   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source