Results 91 to 100 of about 9,659,727 (409)

Celiac Disease Autoimmunity [PDF]

Archivum Immunologiae et Therapiae Experimentalis, 2018
Celiac disease is an autoimmune condition triggered by the ingestion of gluten, the protein fraction of wheat, barley and rye. It is not simply an intestinal disease; it is multifactorial caused by many different genetic factors acting together with non-genetic causes.
Miguel Ángel López Casado, Pedro Lorite, Candelaria Ponce de León, Teresa Palomeque, Maria Isabel Torres   +4 more
openaire   +4 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Clinicopathological Spectrum of Facial Granulomatous Dermatoses: Evidence from a 5-Year Study in Iran

Dermatology Research and Practice
Background. Granulomatous dermatoses, particularly on facial skin, pose a diagnostic challenge, as similar histologic patterns can be produced by different causes. Aim. To evaluate the correlation between clinical suspicion and histopathological findings
Zeinab Aryanian, Mahshid Ansari, Huda Fatima, Mona Homayouni, Azadeh Khayyat, Alireza Ghanadan, Parvaneh Hatami   +6 more
doaj   +1 more source

Family impact of pemphigus disease in an Iranian population using the Family Dermatology Life Quality Index

International Journal of Women's Dermatology, 2020
Background: Pemphigus vulgaris (PV) is a rare but seriously disabling disorder of the skin and mucous membranes that can gravely impact the quality of life (QoL) of patients.
S. Zahra Ghodsi, MD, Arefeh Asadi, MD, Narges Ghandi, MD, Kamran Balighi, MD, Hamidreza Mahmoudi, MD, Robabeh Abedini, MD, Maryam Ghiasi, MD, Vahideh Lajevardi, MD, Cheyda Chams-Davatchi, MD, Maryam Daneshpazhooh, MD   +9 more
doaj  

JAK–STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects

Drugs, 2017
The Janus kinase/signal transduction and activator of transcription (JAK–STAT) signaling pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases including rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
Shubhasree Banerjee, A. Biehl, M. Gadina, S. Hasni, D. Schwartz   +4 more
semanticscholar   +1 more source

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source

Statistical Inference for Genetic Relatedness Based on High-Dimensional Logistic Regression [PDF]

arXiv, 2022
This paper studies the problem of statistical inference for genetic relatedness between binary traits based on individual-level genome-wide association data. Specifically, under the high-dimensional logistic regression models, we define parameters characterizing the cross-trait genetic correlation, the genetic covariance and the trait-specific genetic ...
arxiv  

Shared genetic variants suggest common pathways in allergy and autoimmune diseases. [PDF]

, 2016
BACKGROUND: The relationship between allergy and autoimmune disorders is complex and poorly understood. OBJECTIVE: To investigate commonalities in genetic loci and pathways between allergy and autoimmune diseases to elucidate shared disease mechanisms ...
Adnan Custovic, Alan James, Alexessander Couto Alves, Ananieva, Andersson, Angela Simpson, Bach, Barrett, Bergamaschi, Bhatt, Bønnelykke, Carla M.T. Tiesler, Chen, Chevalier, Clark, Cotsapas, Cotsapas, Craig E. Pennell, David Hinds, David P. Strachan, Dirkje S. Postma, Du, Elaine Fuertes, Elangovan, Eskil Kreiner, Farh, Ferreira, Ferreira, Franke, Fujita, Gerard H. Koppelman, Gohlke, Gudbjartsson, Han, Hans Bisgaard, Hinds, Hirota, Jeffery, Joel N. Hirschhorn, Johannes Waage, John Henderson, Jostins, Joyce Y. Tung, Klaus Bønnelykke, Koch, Kofler, Lango Allen, Lee, Li, Lloyd, Lude Franke, Maier, Manuel A. Ferreira, Marie Standl, Marjo-Riitta Jarvelin, Maurano, Mells, Moffatt, Nair, Nicholas Timpson, Nicole M. Warrington, Palmer, Paternoster, Pers, Petukhova, Pittet, Rabin, Rudwaleit, Sawcer, Sevelsted, Sirota, Stahl, Steinman, Susanne Brix, Tak, Takimoto, Terrados, Tune H. Pers, Urayama, Verhoef, Wang, Welter, Yan, Yoshida, Zhernakova   +84 more
core   +4 more sources

Selective JAKinibs: Prospects in Inflammatory and Autoimmune Diseases

BioDrugs, 2019
Cytokines, many of which signal through the JAK–STAT (Janus kinase–Signal Transducers and Activators of Transcription) pathway, play a central role in the pathogenesis of inflammatory and autoimmune diseases.
Anniina T Virtanen, T. Haikarainen, Juuli Raivola, O. Silvennoinen   +3 more
semanticscholar   +1 more source

Comparative activity of dimethyl fumarate derivative IDMF in three models relevant to multiple sclerosis and psoriasis

FEBS Open Bio, EarlyView.
IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He, Guiyi Gong, Geovani Quijas, Simon Ming‐Yuen Lee, Ratan K. Chaudhuri, Krzysztof Bojanowski   +5 more
wiley   +1 more source