Results 101 to 110 of about 9,706,967 (334)

Pemphigus Vulgaris Activity Score and Assessment of Convergent Validity

Acta Medica Iranica, 2013
Pemphigus is a rare autoimmune blistering disease with different phenotypes. The evaluation of therapeutic interventions requires a reliable, valid and feasible to use measurement.
Cheyda Chams-Davatchi, Ziba Rahbar, Maryam Daneshpazhooh, Seyed Mohammad Ali Mortazavizadeh, Maryam Akhyani, Nafiseh Esmaili, Kamran Balighi   +6 more
doaj  

The study of factors associated with pregnancy outcomes in patients with systemic lupus erythematosus

BMC Research Notes, 2020
Objectives Systemic lupus erythematosus (SLE) is an autoimmune disease that can lead to unfavorable pregnancy complications in women. This study aimed to evaluate the factors associated with pregnancy outcomes in patients with SLE.
Batool Zamani, Mohammad Shayestehpour, Farifteh Esfahanian, Hossein Akbari   +3 more
doaj   +1 more source

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.

Journal of Medicinal Chemistry, 2019
Small molecule JAK inhibitors have emerged as a major therapeutic advancement in treating autoimmune diseases. The discovery of isoform selective JAK inhibitors that traditionally target the catalytically active site of this kinase family has been a ...
Stephen T. Wrobleski, R. Moslin, S. Lin, Yanlei Zhang, S. Spergel, J. Kempson, J. Tokarski, J. Strnad, A. Zupa-Fernandez, Lihong Cheng, D. Shuster, Kathleen M. Gillooly, Xiaoxia Yang, Elizabeth M. Heimrich, K. McIntyre, C. Chaudhry, Javed A Khan, M. Ruzanov, J. Tredup, Dawn Mulligan, D. Xie, Huadong Sun, Christine S. Huang, C. D’arienzo, N. Araníbar, M. Chiney, A. Chimalakonda, W. Pitts, L. Lombardo, P. Carter, J. Burke, D. Weinstein   +31 more
semanticscholar   +1 more source

Galectin-3 in autoimmunity and autoimmune diseases [PDF]

Experimental Biology and Medicine, 2015
Galectin-3 (gal-3) is a β-galactoside-binding lectin, which regulates cell–cell and extracellular interactions during self/non-self-antigen recognition and cellular activation, proliferation, differentiation, migration and apoptosis. It plays a significant role in cellular and tissue pathophysiology by organizing niches that drive inflammation and ...
de Oliveira, Felipe L, GATTO, MARIELE, BASSI, NICOLA, LUISETTO, ROBERTO, GHIRARDELLO, ANNA, PUNZI, LEONARDO, DORIA, ANDREA   +6 more
openaire   +5 more sources

Mayaro: an emerging viral threat?

Emerging Microbes and Infections, 2018
Mayaro virus (MAYV), an enveloped RNA virus, belongs to the Togaviridae family and Alphavirus genus. This arthropod-borne virus (Arbovirus) is similar to Chikungunya (CHIKV), Dengue (DENV), and Zika virus (ZIKV).
Yeny Acosta-Ampudia, Diana M. Monsalve, Yhojan Rodríguez, Yovana Pacheco, Juan-Manuel Anaya, Carolina Ramírez-Santana   +5 more
doaj   +1 more source

The Role of Monocytes and Macrophages in Autoimmune Diseases: A Comprehensive Review

Frontiers in Immunology, 2019
Monocytes (Mo) and macrophages (Mϕ) are key components of the innate immune system and are involved in regulation of the initiation, development, and resolution of many inflammatory disorders. In addition, these cells also play important immunoregulatory
Wen-Tao Ma, Fei Gao, Kui Gu, De-kun Chen
semanticscholar   +1 more source

Discontinuation of Immunotherapy in Patients With Relapsing Myelitis Without AQP4/MOG Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study assesses the outcomes of immunotherapy discontinuation in patients with relapsing seronegative idiopathic myelitis (SIM), a condition that remains uninvestigated due to its rarity. We reviewed records from 77 patients with relapsing SIM at the National Cancer Center of Korea, focusing on 11 who discontinued treatment after a median ...
Ki Hoon Kim, You‐Ri Kang, Jae‐Won Hyun, Su‐Hyun Kim, Ho Jin Kim   +4 more
wiley   +1 more source

IRF5 suppresses metastasis through the regulation of tumor-derived extracellular vesicles and pre-metastatic niche formation

Scientific Reports
Metastasis is driven by extensive cooperation between a tumor and its microenvironment, resulting in the adaptation of molecular mechanisms that evade the immune system and enable pre-metastatic niche (PMN) formation.
Bailey K. Roberts, Dan Iris Li, Carter Somerville, Bharati Matta, Vaishali Jha, Adison Steinke, Zarina Brune, Lionel Blanc, Samuel Z. Soffer, Betsy J. Barnes   +9 more
doaj   +1 more source

SARS‐CoV‐2 Is Linked to Brain Volume Loss in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The impact of SARS‐CoV‐2 infection on brain and spinal cord pathology in patients with multiple sclerosis (pwMS) remains unclear. We aimed to describe changes in brain lesion activity and brain and spinal cord volumes following SARS‐CoV‐2 infection.
Tomas Uher, Dominika Stastna, Ingrid Menkyova, Vaclav Capek, Jiri Lindner, Petra Nytrova, Jan Krasensky, Eliza Varju, Miguel D'haeseleer, Eva Kubala Havrdova, Dana Horakova, Manuela Vaneckova, Niels Bergsland   +12 more
wiley   +1 more source

The Immune System [PDF]

, 1995
Modern biotherapy has been in use for some 30 years. The first types of biotherapy were nonspecific stimulators of the immune response, but advances in genetic engineering are allowing the mass production of pure biological products which are now being ...
Gallucci, Betty Bierut, McCarthy, Donna O.   +1 more
core   +1 more source