Results 251 to 260 of about 9,455,042 (324)

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

Advanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang, Lin Tang, Yusi Wang, Xuejing Zhou, Zhenyu Ding, Li Yang   +5 more
wiley   +1 more source

Autoantibodies in chronic lymphocytic leukemia and related systemic autoimmune diseases [PDF]

, 1993
TJ Kipps, DA Carson
openalex   +1 more source

STING Agonists and How to Reach Their Full Potential in Cancer Immunotherapy

Advanced Science, EarlyView.
STING agonists show promise in preclinical studies in boosting an anti‐tumor response using the immune system. However, different limitations remain, and future research is needed to better understand how STING activation impacts the tumor microenvironment, identify effective combination strategies, and determine the best tumor types for STING agonist ...
Laura Gehrcken, Christophe Deben, Evelien Smits, Jonas R.M. Van Audenaerde   +3 more
wiley   +1 more source

Advance in chimeric antigen receptor T therapy in autoimmune diseases. [PDF]

Front Immunol
Ji X, Sun Y, Xie Y, Gao J, Zhang J.
europepmc   +1 more source

A case of autoimmune hemolytic anemia associated with Graves' disease.

, 1986
Masaya MUKAI, Ichiro Watanabe, K. Tanimura, Masato Shimizu, Ichiro Oki, Katsunori Ohnishi, Atsushi Fujisaku, Hôji SUZUKI, Shôichi NAKAGAWA, Akira Sagawa   +9 more
openalex   +2 more sources

Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice. [PDF]

, 1994
Jian Wu, Tianyu Zhou, J Zhang, Jin He, William C. Gause, J D Mountz   +5 more
openalex   +1 more source

Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

Advanced Science, EarlyView.
This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua, Limin Kong, Li Fan, Yanan Bai, Yujun Zhou, Yanfang Zhang, Qingwei Zhao, Xiaoyang Lu, Hongyu Yang, Hangyang Li, Peili Ding, Yuyu Nan, Qinghua Ji, Ping Yang, Lu Li, Yijing Xin, Lijuan Zhao, Wei Yang, Wenqiao Yu, Saiping Jiang   +19 more
wiley   +1 more source

Proteolysis of TAM receptors in autoimmune diseases and cancer: what does it say to us? [PDF]

Cell Death Dis
Malikova I, Worth A, Aliyeva D, Khassenova M, Kriajevska MV, Tulchinsky E.   +5 more
europepmc   +1 more source

Significance of Circulating Anti-Thyroid Stimulating Hormone (TSH) Receptor Antibodies in Patients with Autoimmune Thyroid Diseases

, 1989
Takashi Fujihira
openalex   +2 more sources

Optimization of Lipid Nanoparticles with Robust Efficiency for the Delivery of Protein Therapeutics to Augment Cancer Immunotherapy

Advanced Science, EarlyView.
This study develops lipid nanoparticles (LNPs) combining cationic and ionizable lipids for efficient cytosolic protein delivery. Optimized LNPs deliver functional proteins, including antibodies, enzymes, and Cas9, with high serum stability and albumin‐mediated endocytosis.
Lanfang Ren, Zeda Zhao, Yuqing Chao, Panting Yu, Zhoufang Mei, Bing Du, Yiyun Cheng   +6 more
wiley   +1 more source