Results 21 to 30 of about 221,041 (347)

Viruses and Autoimmunity: A Review on the Potential Interaction and Molecular Mechanisms

Viruses, 2019
For a long time, viruses have been shown to modify the clinical picture of several autoimmune diseases, including type 1 diabetes (T1D), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome (SS), herpetic stromal keratitis ...
M. Smatti, F. Cyprian, Gheyath K Nasrallah, A. A. Al Thani, Ruba Almishal, H. Yassine   +5 more
semanticscholar   +1 more source

The Balance of Th17 versus Treg Cells in Autoimmunity

International Journal of Molecular Sciences, 2018
T helper type 17 (Th17) cells and pTreg cells, which share a common precursor cell (the naïve CD4 T cell), require a common tumor growth factor (TGF)-β signal for initial differentiation.
G. Lee
semanticscholar   +1 more source

Autoimmune Hepatitis [PDF]

Current Pediatric Reviews, 2015
Autoimmune hepatitis (AIH) is a severe hepatopathy characterised by female preponderance, hypertransaminasaemia, elevated levels of immunoglobulin (IgG), presence of serum autoantibodies and, histologically, by interface hepatitis. AIH occurs both in adults and children, being particularly aggressive in the latter.
Longhi, Maria Serena, Mieli-Vergani, Giorgina, Vergani, Diego   +2 more
openaire   +5 more sources

Targets of Neutrophil Influx and Weaponry: Therapeutic Opportunities for Chronic Obstructive Airway Disease

Journal of Immunology Research, 2017
Neutrophils are important effector cells of antimicrobial immunity in an acute inflammatory response, with a primary role in the clearance of extracellular pathogens.
Carina Kärrman Mårdh, James Root, Mohib Uddin, Kristina Stenvall, Anna Malmgren, Kostas Karabelas, Matthew Thomas   +6 more
doaj   +1 more source

Environmental factors associated with juvenile idiopathic inflammatory myopathy clinical and serologic phenotypes

Pediatric Rheumatology Online Journal, 2022
Background Environmental exposures have been associated with the juvenile idiopathic inflammatory myopathies (JIIM). We undertook a questionnaire-based study to evaluate patient-reported exposures as possible risk factors for JIIM.
Jonathan C. Scalabrini, Adam I. Schiffenbauer, Payam Noroozi Farhadi, Rita Volochayev, Nastaran Bayat, Anna Jansen, Ira N. Targoff, Frederick W. Miller, Lisa G. Rider   +8 more
doaj   +1 more source

Anti-Carbamylated Protein (Anti-CarP) Antibodies in Patients Evaluated for Suspected Rheumatoid Arthritis

Diagnostics, 2022
(1) Background: Anti-carbamylated protein (CarP) antibodies have been studied as novel markers to aid in the diagnosis and prognosis of rheumatoid arthritis.
Vincent Ricchiuti, Kelly Y. Chun, Jane M. Yang, Mary Ann Aure, Luis Gomez, Gary L. Norman, Michael Mahler   +6 more
doaj   +1 more source

PBMC fixation and processing for Chromium single-cell RNA sequencing

Journal of Translational Medicine, 2018
Background Interest in single-cell transcriptomic analysis is growing rapidly, especially for profiling rare or heterogeneous populations of cells. In almost all reported works investigators have used live cells, which introduces cell stress during ...
Jinguo Chen, Foo Cheung, Rongye Shi, Huizhi Zhou, Wenrui Lu, CHI Consortium   +5 more
doaj   +1 more source

CD38: An Immunomodulatory Molecule in Inflammation and Autoimmunity

Frontiers in Immunology, 2020
CD38 is a molecule that can act as an enzyme, with NAD-depleting and intracellular signaling activity, or as a receptor with adhesive functions. CD38 can be found expressed either on the cell surface, where it may face the extracellular milieu or the ...
Z. Piedra-Quintero, Zachary T. Wilson, Porfirio Nava, M. Guerau-de-Arellano   +3 more
semanticscholar   +1 more source

Clinical Factors Associated with Time-Specific Distribution of 18F-Fluorodeoxyglucose in Large-Vessel Vasculitis

Scientific Reports, 2019
18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) can detect vascular inflammation in large-vessel vasculitis (LVV). Clinical factors that influence distribution of FDG into the arterial wall and other tissues have not been characterized in
Joel S. Rosenblum, Kaitlin A. Quinn, Casey A. Rimland, Nehal N. Mehta, Mark A. Ahlman, Peter C. Grayson   +5 more
doaj   +1 more source

Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium

Respiratory Research, 2017
Background Smoking and aberrant epithelial responses are risk factors for lung cancer as well as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.
Lynne A. Murray, Rebecca Dunmore, Ana Camelo, Carla A. Da Silva, Malin J. Gustavsson, David M. Habiel, Tillie L Hackett, Cory M. Hogaboam, Matthew A. Sleeman, Darryl A. Knight   +9 more
doaj   +1 more source