Results 21 to 30 of about 339,261 (412)
Diagnostics, 2023 Anti-neutrophil cytoplasmic antibodies (ANCA) directed to proteinase 3 (PR3) represent highly established markers for patients with ANCA-associated vasculitis (AAV). PR3-ANCA have also demonstrated utility in the management of inflammatory bowel disease (
Carmen Andalucía +5 more
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Kinase inhibition in autoimmunity and inflammation
Nature reviews. Drug discovery, 2020 Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet medical needs in some areas still exist. One of the main therapeutic approaches to alleviate dysregulated inflammation has been to target the activity of kinases that
Ali A. Zarrin +3 more
semanticscholar +1 more source
STIM1 at the plasma membrane as a new target in progressive chronic lymphocytic leukemia
Journal for ImmunoTherapy of Cancer, 2019 Background Dysregulation in calcium (Ca2+) signaling is a hallmark of chronic lymphocytic leukemia (CLL). While the role of the B cell receptor (BCR) Ca2+ pathway has been associated with disease progression, the importance of the newly described ...
Marjolaine Debant +14 more
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dcHiC detects differential compartments across multiple Hi-C datasets
Nature Communications, 2022 The organisation of mammalian genomes plays a role in many biological processes. Here the authors report dcHiC, a tool which uses a multivariate distance measure to identify changes in compartmentalisation among multiple genome-wide chromatin contact ...
Abhijit Chakraborty +2 more
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Cell Communication and Signaling, 2019 Background The airway epithelium is a major target tissue in respiratory infections, and its antiviral response is mainly orchestrated by the interferon regulatory factor-3 (IRF3), which subsequently induces type I (β) and III (λ) interferon (IFN ...
Engin Baturcam +7 more
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Journal of Clinical and Translational Science, 2021 IMPACT: Better understanding of the factors impacting disease severity and immunological response of MS patients on disease modifying therapy will enable better recommendations for vaccination options and risk mitigation strategies OBJECTIVES/GOALS: The ...
Ahya S Ali, Yang Mao-Draayer
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Pathogenic mechanisms of IgE-mediated inflammation in self-destructive autoimmune responses
Autoimmunity, 2017 Autoantibodies of the IgG subclass are pathogenic in a number of autoimmune disorders such as systemic lupus erythomatosus. The presence of circulating IgE autoantibodies in autoimmune patients has also been known for almost 40 years.
Rachel Ettinger +6 more
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Stochastic effects in autoimmune dynamics [PDF]
Frontiers in Physiology 9, 45 (2018), 2018 Among various possible causes of autoimmune disease, an important role is played by infections that can result in a breakdown of immune tolerance, primarily through the mechanism of "molecular mimicry". In this paper we propose and analyse a stochastic model of immune response to a viral infection and subsequent autoimmunity, with account for the ...
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Past, Present, and Future of Regulatory T Cell Therapy in Transplantation and Autoimmunity
Frontiers in Immunology, 2019 Regulatory T cells (Tregs) are important for the induction and maintenance of peripheral tolerance therefore, they are key in preventing excessive immune responses and autoimmunity. In the last decades, several reports have been focussed on understanding
M. Romano +4 more
semanticscholar +1 more source
Effects of viral and cytokine delays on dynamics of autoimmunity [PDF]
Mathematics 6, 66 (2018), 2018 A major contribution to the onset and development of autoimmune disease is known to come from infections. An important practical problem is identifying the precise mechanism by which the breakdown of immune tolerance as a result of immune response to infection leads to autoimmunity. In this paper, we develop a mathematical model of immune response to a
arxiv +1 more source