Results 21 to 30 of about 153,226 (196)

PBMC fixation and processing for Chromium single-cell RNA sequencing

Journal of Translational Medicine, 2018
Background Interest in single-cell transcriptomic analysis is growing rapidly, especially for profiling rare or heterogeneous populations of cells. In almost all reported works investigators have used live cells, which introduces cell stress during ...
Jinguo Chen, Foo Cheung, Rongye Shi, Huizhi Zhou, Wenrui Lu, CHI Consortium   +5 more
doaj   +1 more source

CD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition

Nature Communications, 2021
CD45 limits T cell activation, so its exclusion from the T cell immunological synapse is thought to occur as a means to enable TCR signalling. Here the authors use a variety of cellular imaging methods to show that CD45 is indeed excluded from the tips ...
Yunmin Jung, Lai Wen, Amnon Altman, Klaus Ley   +3 more
doaj   +1 more source

Clinical Factors Associated with Time-Specific Distribution of 18F-Fluorodeoxyglucose in Large-Vessel Vasculitis

Scientific Reports, 2019
18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) can detect vascular inflammation in large-vessel vasculitis (LVV). Clinical factors that influence distribution of FDG into the arterial wall and other tissues have not been characterized in
Joel S. Rosenblum, Kaitlin A. Quinn, Casey A. Rimland, Nehal N. Mehta, Mark A. Ahlman, Peter C. Grayson   +5 more
doaj   +1 more source

Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium

Respiratory Research, 2017
Background Smoking and aberrant epithelial responses are risk factors for lung cancer as well as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.
Lynne A. Murray, Rebecca Dunmore, Ana Camelo, Carla A. Da Silva, Malin J. Gustavsson, David M. Habiel, Tillie L Hackett, Cory M. Hogaboam, Matthew A. Sleeman, Darryl A. Knight   +9 more
doaj   +1 more source

Low-Dose Rapamycin Unmasks the Protective Potential of Targeting Intragraft NF-κB for Islet Transplants

Cell Transplantation, 2013
Islet grafts can contribute to their own destruction via the elaboration of proinflammatory genes, many of which are transcriptionally regulated by nuclear factor κ-light-chain-enhancer of activated B-cells (NF-κB).
Nathan W. Zammit, Bernice M. Tan, Stacey N. Walters, David Liuwantara, Jeanette E. Villanueva, Elisabeth K. Malle, Shane T. Grey   +6 more
doaj   +1 more source

IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE

Nature Communications, 2018
Systemic lupus erythematosus (SLE) is associated with altered B cell responses but the underlying aetiology is still unclear. Here the authors show that a CD11chiT-bet+ B cell subset with a unique phenotype and transcriptome is increased in patients with
Shu Wang, Jingya Wang, Varsha Kumar, Jodi L. Karnell, Brian Naiman, Phillip S. Gross, Saifur Rahman, Kamelia Zerrouki, Richard Hanna, Christopher Morehouse, Nicholas Holoweckyj, Hao Liu, Autoimmunity Molecular Medicine Team, Zerai Manna, Raphaela Goldbach-Mansky, Sarfaraz Hasni, Richard Siegel, Miguel Sanjuan, Katie Streicher, Michael P. Cancro, Roland Kolbeck, Rachel Ettinger   +21 more
doaj   +1 more source

Corneal Confocal Microscopy in the Diagnosis of Small Fiber Neuropathy: Faster, Easier, and More Efficient Than Skin Biopsy?

Pathophysiology, 2021
Chronic pain may affect 30–50% of the world’s population and an important cause is small fiber neuropathy (SFN). Recent research suggests that autoimmune diseases may be one of the most common causes of small nerve fiber damage. There is low awareness of
Mariia V. Lukashenko, Natalia Y. Gavrilova, Anna V. Bregovskaya, Lidiia A. Soprun, Leonid P. Churilov, Ioannis N. Petropoulos, Rayaz A Malik, Yehuda Shoenfeld   +7 more
doaj   +1 more source

The Effect of BAFF Inhibition on Autoreactive B-Cell Selection in Murine Systemic Lupus Erythematosus

Molecular Medicine, 2016
The goal of this study was to determine how B-cell-activating factor of the TNF family (BAFF) availability influences selection of the autoreactive B-cell repertoire in NZB/W and NZW/BXSB lupus-prone mice bearing the site-directed heavy-chain transgene ...
Alexis Boneparth, Megan Woods, Weiqing Huang, Meredith Akerman, Martin Lesser, Anne Davidson   +5 more
doaj   +1 more source

Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice

Nature Communications, 2021
Autoimmunity mediated by age-associated B cells (ABC) can affect males and females differently. Here, using a lupus-like mouse model that affects females more severely, the authors observe an ABC mediated and guanine nucleotide exchange factor (GEF ...
Edd Ricker, Michela Manni, Danny Flores-Castro, Daniel Jenkins, Sanjay Gupta, Juan Rivera-Correa, Wenzhao Meng, Aaron M. Rosenfeld, Tania Pannellini, Mahesh Bachu, Yurii Chinenov, Peter K. Sculco, Rolf Jessberger, Eline T. Luning Prak, Alessandra B. Pernis   +14 more
doaj   +1 more source

Cytokines in autoimmunity

Current Opinion in Immunology, 1992
The past few years have witnessed exciting developments regarding the role of cytokines in autoimmune diseases, particularly in rheumatoid arthritis and Crohn's disease, with the demonstration that anti-TNF alpha therapy is clinically beneficial and provides reproducible results.
Brennan, F, Feldmann, M
openaire   +4 more sources