Results 31 to 40 of about 207,009 (370)
Stochastic effects in autoimmune dynamics [PDF]
Frontiers in Physiology 9, 45 (2018), 2018 Among various possible causes of autoimmune disease, an important role is played by infections that can result in a breakdown of immune tolerance, primarily through the mechanism of "molecular mimicry". In this paper we propose and analyse a stochastic model of immune response to a viral infection and subsequent autoimmunity, with account for the ...
arxiv +1 more source
Pediatric Rheumatology Online Journal, 2022 Background Environmental exposures have been associated with the juvenile idiopathic inflammatory myopathies (JIIM). We undertook a questionnaire-based study to evaluate patient-reported exposures as possible risk factors for JIIM.
Jonathan C. Scalabrini +8 more
doaj +1 more source
Translocation of a gut pathobiont drives autoimmunity in mice and humans
Science, 2018 Bacterial involvement in autoimmunity The composition of the commensal microbiota is known to influence autoimmune disease development and persistence. Manfredo Vieira et al.
S. Vieira +16 more
semanticscholar +1 more source
Effects of viral and cytokine delays on dynamics of autoimmunity [PDF]
Mathematics 6, 66 (2018), 2018 A major contribution to the onset and development of autoimmune disease is known to come from infections. An important practical problem is identifying the precise mechanism by which the breakdown of immune tolerance as a result of immune response to infection leads to autoimmunity. In this paper, we develop a mathematical model of immune response to a
arxiv +1 more source
PBMC fixation and processing for Chromium single-cell RNA sequencing
Journal of Translational Medicine, 2018 Background Interest in single-cell transcriptomic analysis is growing rapidly, especially for profiling rare or heterogeneous populations of cells. In almost all reported works investigators have used live cells, which introduces cell stress during ...
Jinguo Chen +5 more
doaj +1 more source
CD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition
Nature Communications, 2021 CD45 limits T cell activation, so its exclusion from the T cell immunological synapse is thought to occur as a means to enable TCR signalling. Here the authors use a variety of cellular imaging methods to show that CD45 is indeed excluded from the tips ...
Yunmin Jung +3 more
doaj +1 more source
Scientific Reports, 2019 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) can detect vascular inflammation in large-vessel vasculitis (LVV). Clinical factors that influence distribution of FDG into the arterial wall and other tissues have not been characterized in
Joel S. Rosenblum +5 more
doaj +1 more source
Respiratory Research, 2017 Background Smoking and aberrant epithelial responses are risk factors for lung cancer as well as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.
Lynne A. Murray +9 more
doaj +1 more source
Application of High-Throughput Imaging Mass Cytometry Hyperion in Cancer Research
Frontiers in Immunology, 2022 Imaging mass cytometry (IMC) enables the in situ analysis of in-depth-phenotyped cells in their native microenvironment within the preserved architecture of a single tissue section.
Marion Le Rochais +5 more
doaj +1 more source
Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes
Science, 2002 We report here the adoptive transfer, to patients with metastatic melanoma, of highly selected tumor-reactive T cells directed against overexpressed self-derived differentiation antigens after a nonmyeloablative conditioning regimen.
M. Dudley +18 more
semanticscholar +1 more source