Results 31 to 40 of about 221,041 (347)

CD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition

Nature Communications, 2021
CD45 limits T cell activation, so its exclusion from the T cell immunological synapse is thought to occur as a means to enable TCR signalling. Here the authors use a variety of cellular imaging methods to show that CD45 is indeed excluded from the tips ...
Yunmin Jung, Lai Wen, Amnon Altman, Klaus Ley   +3 more
doaj   +1 more source

Low-Dose Rapamycin Unmasks the Protective Potential of Targeting Intragraft NF-κB for Islet Transplants

Cell Transplantation, 2013
Islet grafts can contribute to their own destruction via the elaboration of proinflammatory genes, many of which are transcriptionally regulated by nuclear factor κ-light-chain-enhancer of activated B-cells (NF-κB).
Nathan W. Zammit, Bernice M. Tan, Stacey N. Walters, David Liuwantara, Jeanette E. Villanueva, Elisabeth K. Malle, Shane T. Grey   +6 more
doaj   +1 more source

Autoimmune pancreatitis [PDF]

Gastroenterology Report, 2013
Autoimmune pancreatitis (AIP) is a rare, heterogeneous, fibroinflammatory disorder of the pancreas. It has gained increasing recognition due to a presentation that can mimic difficult to treat disorders such as pancreatic cancer, cholangiocarcinoma and primary sclerosing cholangitis. In contrast, autoimmune pancreatitis is a benign disease that is very
Ketwaroo, Gyanprakash A., Sheth, Sunil
openaire   +3 more sources

IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE

Nature Communications, 2018
Systemic lupus erythematosus (SLE) is associated with altered B cell responses but the underlying aetiology is still unclear. Here the authors show that a CD11chiT-bet+ B cell subset with a unique phenotype and transcriptome is increased in patients with
Shu Wang, Jingya Wang, Varsha Kumar, Jodi L. Karnell, Brian Naiman, Phillip S. Gross, Saifur Rahman, Kamelia Zerrouki, Richard Hanna, Christopher Morehouse, Nicholas Holoweckyj, Hao Liu, Autoimmunity Molecular Medicine Team, Zerai Manna, Raphaela Goldbach-Mansky, Sarfaraz Hasni, Richard Siegel, Miguel Sanjuan, Katie Streicher, Michael P. Cancro, Roland Kolbeck, Rachel Ettinger   +21 more
doaj   +1 more source

Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice

Science Translational Medicine, 2020
Gut microbiota dysbiosis induces lupus-like autoimmunity in mice through altered tryptophan catabolism. The advantage of reducing dietary tryptophan Alterations in the gut microbiota may contribute to autoimmunity through bacterial-mediated immune ...
Seung-Chul Choi, Josephine Brown, Minghao Gong, Yong Ge, M. Zadeh, Wei Li, B. Croker, G. Michailidis, T. Garrett, M. Mohamadzadeh, L. Morel   +10 more
semanticscholar   +1 more source

The Effect of BAFF Inhibition on Autoreactive B-Cell Selection in Murine Systemic Lupus Erythematosus

Molecular Medicine, 2016
The goal of this study was to determine how B-cell-activating factor of the TNF family (BAFF) availability influences selection of the autoreactive B-cell repertoire in NZB/W and NZW/BXSB lupus-prone mice bearing the site-directed heavy-chain transgene ...
Alexis Boneparth, Megan Woods, Weiqing Huang, Meredith Akerman, Martin Lesser, Anne Davidson   +5 more
doaj   +1 more source

Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice

Nature Communications, 2021
Autoimmunity mediated by age-associated B cells (ABC) can affect males and females differently. Here, using a lupus-like mouse model that affects females more severely, the authors observe an ABC mediated and guanine nucleotide exchange factor (GEF ...
Edd Ricker, Michela Manni, Danny Flores-Castro, Daniel Jenkins, Sanjay Gupta, Juan Rivera-Correa, Wenzhao Meng, Aaron M. Rosenfeld, Tania Pannellini, Mahesh Bachu, Yurii Chinenov, Peter K. Sculco, Rolf Jessberger, Eline T. Luning Prak, Alessandra B. Pernis   +14 more
doaj   +1 more source

Corneal Confocal Microscopy in the Diagnosis of Small Fiber Neuropathy: Faster, Easier, and More Efficient Than Skin Biopsy?

Pathophysiology, 2021
Chronic pain may affect 30–50% of the world’s population and an important cause is small fiber neuropathy (SFN). Recent research suggests that autoimmune diseases may be one of the most common causes of small nerve fiber damage. There is low awareness of
Mariia V. Lukashenko, Natalia Y. Gavrilova, Anna V. Bregovskaya, Lidiia A. Soprun, Leonid P. Churilov, Ioannis N. Petropoulos, Rayaz A Malik, Yehuda Shoenfeld   +7 more
doaj   +1 more source

The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity

Cell Research, 2020
Co-inhibitory receptors are important regulators of T-cell function that define the balance between tolerance and autoimmunity. The immune regulatory function of co-inhibitory receptors, including CTLA-4, PD-1, TIM-3, TIGIT, and LAG-3, was first ...
Alexandra Schnell, Lloyd Bod, A. Madi, V. Kuchroo   +3 more
semanticscholar   +1 more source

Pathogenesis of autoimmune demyelination: from multiple sclerosis to neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody‐associated disease

Clinical & Translational Immunology, 2021
Autoimmunity plays a significant role in the pathogenesis of demyelination. Multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) are now recognised as ...
Joseph A Lopez, Martina Denkova, Sudarshini Ramanathan, Russell C Dale, Fabienne Brilot   +4 more
doaj   +1 more source