Results 51 to 60 of about 349,570 (384)

Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity. [PDF]

, 2010
Peroxisome proliferator-activated receptors (PPARs; PPAR-alpha, PPAR-delta, and PPAR-gamma) comprise a family of nuclear receptors that sense fatty acid levels and translate this information into altered gene transcription.
Axtell, Robert, Bhat, Roopa, Chawla, Ajay, Dugas, Jason C, Dunn, Shannon E, Johnson, Amanda, Moshkova, Marina, Mukundan, Lata, Nguyen, Kim, Sobel, Raymond A, Steinman, Lawrence, Straus, Daniel S   +11 more
core   +3 more sources

The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity

Cell Research, 2020
Co-inhibitory receptors are important regulators of T-cell function that define the balance between tolerance and autoimmunity. The immune regulatory function of co-inhibitory receptors, including CTLA-4, PD-1, TIM-3, TIGIT, and LAG-3, was first ...
Alexandra Schnell, Lloyd Bod, A. Madi, V. Kuchroo   +3 more
semanticscholar   +1 more source

Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice

Nature Communications, 2021
Autoimmunity mediated by age-associated B cells (ABC) can affect males and females differently. Here, using a lupus-like mouse model that affects females more severely, the authors observe an ABC mediated and guanine nucleotide exchange factor (GEF ...
Edd Ricker, Michela Manni, Danny Flores-Castro, Daniel Jenkins, Sanjay Gupta, Juan Rivera-Correa, Wenzhao Meng, Aaron M. Rosenfeld, Tania Pannellini, Mahesh Bachu, Yurii Chinenov, Peter K. Sculco, Rolf Jessberger, Eline T. Luning Prak, Alessandra B. Pernis   +14 more
doaj   +1 more source

Application of High-Throughput Imaging Mass Cytometry Hyperion in Cancer Research

Frontiers in Immunology, 2022
Imaging mass cytometry (IMC) enables the in situ analysis of in-depth-phenotyped cells in their native microenvironment within the preserved architecture of a single tissue section.
Marion Le Rochais, Marion Le Rochais, Patrice Hemon, Jacques-Olivier Pers, Arnaud Uguen, Arnaud Uguen   +5 more
doaj   +1 more source

MALT1 proteolytic activity suppresses autoimmunity in a T cell intrinsic manner [PDF]

, 2019
MALT1 is a central signaling component in innate and adaptive immunity by regulating NF-kappa B and other key signaling pathways in different cell types. Activities of MALT1 are mediated by its scaffold and protease functions.
Baens, Mathijs, Beyaert, Rudi, Demeyer, Annelies, Driege, Yasmine, Hochepied, Tino, Kreike, Marja, Skordos, Ioannis, Staal, Jens   +7 more
core   +2 more sources

Web Tool for Navigating and Plotting SomaLogic ADAT Files

Journal of Open Research Software, 2017
SOMAscan™ is a complex proteomic platform created by SomaLogic. Experimental data resulting from the assay is provided by SomaLogic in a proprietary text-based format called ADAT.
Foo Cheung, Giovanna Fantoni, Maria Conner, Brian A. Sellers, Yuri Kotliarov, Julián Candia, Katherine Stagliano, Angélique Biancotto   +7 more
doaj   +1 more source

Mustache: multi-scale detection of chromatin loops from Hi-C and Micro-C maps using scale-space representation

Genome Biology, 2020
We present Mustache, a new method for multi-scale detection of chromatin loops from Hi-C and Micro-C contact maps. Mustache employs scale-space theory, a technical advance in computer vision, to detect blob-shaped objects in contact maps.
Abbas Roayaei Ardakany, Halil Tuvan Gezer, Stefano Lonardi, Ferhat Ay   +3 more
doaj   +1 more source

Corneal Confocal Microscopy in the Diagnosis of Small Fiber Neuropathy: Faster, Easier, and More Efficient Than Skin Biopsy?

Pathophysiology, 2021
Chronic pain may affect 30–50% of the world’s population and an important cause is small fiber neuropathy (SFN). Recent research suggests that autoimmune diseases may be one of the most common causes of small nerve fiber damage. There is low awareness of
Mariia V. Lukashenko, Natalia Y. Gavrilova, Anna V. Bregovskaya, Lidiia A. Soprun, Leonid P. Churilov, Ioannis N. Petropoulos, Rayaz A Malik, Yehuda Shoenfeld   +7 more
doaj   +1 more source

Autoimmunity: The nuclear arsenal of autoimmunity [PDF]

Immunology & Cell Biology, 2007
An exciting new work recently published in Nature Immunology shows that an iconic molecule should not get all the blame for carrying out the dirty work of autoimmunity ...
openaire   +3 more sources

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-COVID Syndrome: A Common Neuroimmune Ground?

Diagnostics, 2022
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease of unknown etiology, sharing a similar clinical presentation with the increasingly recognized post-COVID syndrome.
Varvara A. Ryabkova, Natalia Y. Gavrilova, Tamara V. Fedotkina, Leonid P. Churilov, Yehuda Shoenfeld   +4 more
doaj   +1 more source