Autoinducer-2 of gut microbiota, a potential novel marker for human colorectal cancer, is associated with the activation of TNFSF9 signaling in macrophages [PDF]
OncoImmunology, 2019 Objectives: The interaction between the quorum sensing (QS) molecules of gut microbiota and the immunity of colorectal cancer (CRC) has not been investigated before.
Qing Li +8 more
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Quorum sensing LuxS/autoinducer-2 inhibits Enterococcus faecalis biofilm formation ability [PDF]
Journal of Applied Oral Science, 2018 Objective: To investigate the relation between biofilm formation ability and quorum sensing gene LuxS/AI-2. Materials and Methods: Enterococcus faecalis (E. faecalis) standard strain ATCC 29212 was used in the study.
Yue Yang +3 more
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Cryo‐EM structures of pentameric autoinducer‐2 exporter from Escherichia coli reveal its transport mechanism [PDF]
EMBO Journal, 2022 Gerhard Hummer, C V Robinson, Hao Xie
exaly +2 more sources
The structure of LsrB from Yersinia pestis complexed with autoinducer-2 [PDF]
Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2011 The crystal structure of LsrB from Yersinia pestis complexed with autoinducer-2 (AI-2; space group P212121, unit-cell parameters a = 40.61, b = 61.03, c = 125.23 Å) has been solved by molecular replacement using the structure of LsrB from Salmonella typhimurium (PDB entry 1tjy) and refined to R = 0.180 (R free = 0.213) at 1.75 Å ...
Jeffrey S, Kavanaugh +2 more
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Phosphorylation and Processing of the Quorum-Sensing Molecule Autoinducer-2 in Enteric Bacteria [PDF]
ACS Chemical Biology, 2007 Quorum sensing is a process of chemical communication that bacteria use to assess cell population density and synchronize behavior on a community-wide scale. Communication is mediated by signal molecules called autoinducers. The LuxS autoinducer synthase produces 4,5-dihydroxy-2,3-pentanedione (DPD), the precursor to a set of interconverting molecules ...
Xavier, K. B. +7 more
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The Primary Physiological Roles of Autoinducer 2 in Escherichia coli Are Chemotaxis and Biofilm Formation. [PDF]
Microorganisms, 2021 Autoinducer 2 (AI-2) is a ubiquitous metabolite but, instead of acting as a “universal signal,” relatively few phenotypes have been associated with it, and many scientists believe AI-2 is often a metabolic byproduct rather than a signal. Here, the aim is
Song S, Wood TK.
europepmc +2 more sources
An Efficient Synthesis of Optically Active [4-13C] Labelled Quorum Sensing Signal Autoinducer-2. [PDF]
Molecules, 2021 A new synthetic route for the quorum sensing signal Autoinducer-2 (AI-2) is described and used for the preparation of [4-13C]-AI-2 starting from [1-13C]-bromoacetic acid.
Ascenso OS +4 more
europepmc +2 more sources
Autoinducer-2 May Be a New Biomarker for Monitoring Neonatal Necrotizing Enterocolitis. [PDF]
Front Cell Infect Microbiol, 2020 El autoinductor-2 (AI-2) tiene un papel ampliamente aceptado en la comunicación bacteriana intra e interespecie. Poco se sabe sobre las relaciones entre AI-2 y NEC. Este estudio encontró que los niveles de AI-2 en pacientes y en un modelo de ratón NEC se detectaron utilizando el sistema de ensayo Vibrio harveyi BB170.
Fu CY +5 more
europepmc +5 more sources
Bifidobacteria exhibit LuxS-dependent autoinducer 2 activity and biofilm formation. [PDF]
PLoS ONE, 2014 Autoinducer-2 (AI-2) molecules are one class of signalling molecules involved in gene regulation dependent on population density in a mechanism commonly referred to as quorum sensing (QS).
Zhongke Sun +4 more
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Frontiers in Microbiology, 2022 Antivirulence strategy has been developed as a nontraditional therapy which would engender a lower evolutionary pressure toward the development of antimicrobial resistance.
Youwen Zhang +12 more
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