Results 121 to 130 of about 7,703 (178)

Screening of FDA-Approved Small Molecules to Discover Inhibitors of the <i>Pseudomonas aeruginosa</i> Quorum-Sensing Enzyme, PqsE. [PDF]

Biochemistry
Jones HA, Baxter MJ, Zimmermann N, Li A, Perrault Uptmor KA, Taylor IR.   +5 more
europepmc   +1 more source

Autoinducer 2 as a universal language in microbial consortia: decoding molecular mechanisms, ecological impacts, and application. [PDF]

Gut Microbes
Guo S, Mao B, Tang X, Zhang Q, Zhao J, Chen W, Cui S.   +6 more
europepmc   +1 more source

Disruption of <i>Pseudomonas aeruginosa</i> quorum sensing influences biofilm formation without affecting antibiotic tolerance. [PDF]

Microbiology (Reading)
Smith E, Matthews A, Westra ER, Custodio R.   +3 more
europepmc   +1 more source

Antibiofilm compounds from Streptomyces Labedae 20PM improves survival of and prophylactic effect of Nile tilapia (Oreochromis niloticus) challenged with Aeromonas hydrophila. [PDF]

BMC Res Notes
Wahjuningrum D, Tjandra GI, Mauliana A, Herlambang H, Gustilatov M, Waturangi DE.   +5 more
europepmc   +1 more source

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Analogs of the autoinducer of bioluminescence inVibrio fischer

Archives of Microbiology, 1986
The enzymes for luminescence in Vibrio fischeri are induced only when a sufficient concentration of a metabolic product (autoinducer) specifically produced by this species accumulates. It has previously been shown that the autoinducer is 3-oxohexanoyl homoserine lactone and that it enters the cells by simple diffusion. To further study the mechanism of
Anatol Eberhard, A Eberhard
exaly   +3 more sources

The Effect of Anabiosis Autoinducers on the Bacterial Genome

Microbiology, 2002
The mutagenic activity of chemical analogues of microbial anabiosis autoinducers (the autoregulatory d1 factors of cell differentiation), which act to inhibit cell proliferation, to enhance cell tolerance, and to induce the transition of cells to anabiotic state, was studied using the Ames test.
Il'inskaya O., Kolpakov A., Zelenikhin P., Kruglova Z., Choidash B., Doroshenko E., Mulyukin A., El'-Registan G.   +7 more
openaire   +4 more sources

Custom Synthesis of Autoinducers and Their Analogues

2010
Bacterial quorum sensing (QS) system is a unique target for the development of a new class of drugs that potentially control pathogenicity and attenuate virulence. Thus, it has been of significant interest to discover small organic molecules that modulate QS circuits by competing with the signaling molecules, or so-called autoinducers (AIs), for ...
Jun, Igarashi, Hiroaki, Suga
openaire   +2 more sources

Autoinduced synthesis of colicin E2

Molecular and General Genetics MGG, 1983
Escherichia coli K-12 cells carrying the high copy number plasmid ColE2-P9 and a sfiA-lacZ gene fusion exhibit abnormally high levels of SOS-regulated phi sfiA-lacZ expression. Increased sfiA-lacZ expression is caused by the action of colicin E2, which is a DNase, rather than by the presence of multiple copies of a binding site for LexA protein, the ...
openaire   +2 more sources

Novel synthetic analogs of the Pseudomonas autoinducer

Bioorganic & Medicinal Chemistry Letters, 1999
Release of virulence factors in Pseudomonas aeruginosa is regulated by two N-acylhomoserine lactones, PAI-1 and PAI-2, that activate the respective transcription factors LasR and RhlR. With the goal of developing novel therapeutic agents, we synthesized constrained analogs of PAI-1 and evaluated them in P. aeruginosa.
T, Kline, J, Bowman, B H, Iglewski, T, de Kievit, Y, Kakai, L, Passador   +5 more
openaire   +2 more sources